(data stored in ACNUC7421 zone)

HOGENOM: ANAMM_1_PE112

ID   ANAMM_1_PE112                        STANDARD;      PRT;   430 AA.
AC   ANAMM_1_PE112; Q5PBM8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Serine hydroxymethyltransferase; Short=SHMT; Short=Serine
DE   methylase; EC=2.1.2 1; (ANAMM_1.PE112).
GN   Name=glyA; OrderedLocusNames=AM164;
OS   ANAPLASMA MARGINALE STR. ST. MARIES.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Anaplasma.
OX   NCBI_TaxID=234826;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ANAMM_1.PE112.
CC       Anaplasma marginale str. St. Maries, complete genome.
CC       Missing 5 prime End;
CC   -!- ANNOTATIONS ORIGIN:GLYA_ANAMM
CC   -!- FUNCTION: Interconversion of serine and glycine.
CC   -!- CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine +
CC       H(2)O = tetrahydrofolate + L-serine.
CC   -!- COFACTOR: Pyridoxal phosphate (By similarity).
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the SHMT family.
CC   -!- GENE_FAMILY: HOG000239404 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q5PBM8; -.
DR   EMBL; CP000030; AAV86301.1; -; Genomic_DNA.
DR   RefSeq; YP_153556.1; NC_004842.2.
DR   ProteinModelPortal; Q5PBM8; -.
DR   SMR; Q5PBM8; 14-421.
DR   STRING; Q5PBM8; -.
DR   GeneID; 3171408; -.
DR   GenomeReviews; CP000030_GR; AM164.
DR   KEGG; ama:AM164; -.
DR   eggNOG; COG0112; -.
DR   OMA; SHRIDMD; -.
DR   ProtClustDB; PRK00011; -.
DR   BioCyc; AMAR234826:AM164-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006544; P:glycine metabolic process; IEA:InterPro.
DR   GO; GO:0006563; P:L-serine metabolic process; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00051; SHMT; 1; -.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase_major_dom.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major_sub1.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_major_sub2.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR   Gene3D; G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
DR   Gene3D; G3DSA:3.90.1150.10; PyrdxlP-dep_Trfase_major_sub2; 1.
DR   PANTHER; PTHR11680; Gly_HO-Metrfase; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   PIRSF; PIRSF000412; SHMT; 1.
DR   SUPFAM; SSF53383; PyrdxlP-dep_Trfase_major; 1.
DR   PROSITE; PS00096; SHMT; 1.
DR   HOGENOMDNA; ANAMM_1.PE112; -.
KW   Complete proteome; Cytoplasm; One-carbon metabolism;
KW   Pyridoxal phosphate; Transferase.
SQ   SEQUENCE   430 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVGYIGNVDI GVFDAEVANS MSAELERQNT LLQMIASENF VSRAVLQAQG SVLTNKYAEG
     YAGSRYYCGC ALVDVVENLA VERLCRLFGC KFANVQPHSG SQANQQVFMA LLKPGDTILG
     MSLDCGGHLT HGAAPNVSGR WFNAVSYGVN RDTGLIDMDE VEALALSAKP SLIIAGASSY
     PRRIDFAAFR AIADKVGAYL LADIAHYSGL IAGGCYPSPF GHAHVVTSTT HKTLRGPRGA
     VIMTDDEEIH KKIRLSVFPG MQGGPLMHVI AAKAVAFKEA LHPDFKLYAQ QVLENSRVLA
     GVLSSEGLDV VTGGTDSHIV LLDLRSKGVT GREVSSSLER AGIVCNKNAV PFDTEKPWVT
     SGIRLGSAAE TSRGLGVPEF ESIGRLVAKV VNACSLGQEK MSAAEAEVRR EVNGLVRSLP
     MSAFPVCEVC
//

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