(data stored in ACNUC4342 zone)

HOGENOM: ANOCA0_11_PE2

ID   ANOCA0_11_PE2                        STANDARD;      PRT;   305 AA.
AC   ANOCA0_11_PE2; Q9YHT3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Estrogen receptor; Short=ER;AltName: Full=ER-alpha;AltName:
DE   Full=Estradiol receptor;AltName: Full=Nuclear receptor subfamily 3 group
DE   A member 1;Flags: Fragment; (ANOCA0_11.PE2).
GN   Name=ESR1; Synonyms=NR3A1;
OS   ANOLIS CAROLINENSIS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Sauropsida; Sauria; Lepidosauria;
OC   Squamata; Iguania; Iguanidae; Polychrotinae; Anolis.
OX   NCBI_TaxID=28377;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ANOCA0_11.PE2.
CC       Anolis carolinensis scaffold scaffold_0 AnoCar1.0 partial sequence
CC       9829834..10829833 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ESR1_ANOCA
CC   -!- FUNCTION: The steroid hormones and their receptors are involved in
CC       the regulation of eukaryotic gene expression and affect cellular
CC       proliferation and differentiation in target tissues.
CC   -!- SUBUNIT: Binds DNA as a homodimer. Can form a heterodimer with ER-
CC       beta (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Composed of three domains: a modulating N-terminal domain,
CC       a DNA-binding domain and a C-terminal ligand-binding domain.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR3
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.
CC   -!- GENE_FAMILY: HOG000233468 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Anolis_carolinensis;ENSACAG00000006213;ENSACAT00000006243;ENSACAP00000006106.
DR   EMBL; AF095911; - ;
DR   UniProtKB/Swiss-Prot; Q9YHT3; -.
DR   EMBL; AF095911; AAC64412.2; -; mRNA.
DR   UniGene; Acr.47111; -.
DR   ProteinModelPortal; Q9YHT3; -.
DR   SMR; Q9YHT3; 55-304.
DR   Ensembl; ENSACAT00000006243; ENSACAP00000006106; ENSACAG00000006213.
DR   GeneTree; ENSGT00600000084216; -.
DR   OrthoDB; EOG4JM7PP; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0003707; F:steroid hormone receptor activity; IEA:InterPro.
DR   InterPro; IPR008946; Nucl_hormone_rcpt_ligand-bd.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd_core.
DR   InterPro; IPR001723; Str_hrmn_rcpt.
DR   Gene3D; G3DSA:1.10.565.10; Nucl_hrmn_rcpt_lig_bd; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   SMART; SM00430; HOLI; 1.
DR   SUPFAM; SSF48508; Str_ncl_receptor; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; PARTIAL.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; PARTIAL.
DR   HOGENOMDNA; ANOCA0_11.PE2; -.
KW   ENSACAG00000006213; ENSACAP00000006106; ESR1_ANOCA; AF095911;
KW   DNA-binding; Lipid-binding; Metal-binding; Nucleus; Receptor;
KW   Steroid-binding; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
SQ   SEQUENCE   305 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     LLSGIRKDRR GGRMLKHKRQ REENDSRNAG ALTEARSTAL WPSPLMIKHS KKNSPALSLT
     ADQMVSALLE AEPPVVYSEY DPSRPFNEAS VMTLLTNLAD RELVHMINWA KRVPGFVDLA
     LHDQVHLLEC AWLEILMVGL VWRSMEHPGK LLFAPNLLLD RSHGKVVEGF VEIFDMLLAT
     SSRFRMMNVR GEEFVCLKSI ILLNSGIYTY LSSTLKSVEE KDHIHRVLDK ITDTLMHLMA
     KSGLSLQQQH RRLAQLLLIL SHIRHMSNKG MEHLYSMKCK NVVPLYDLLL EMLDAHRLHA
     PAAKG
//

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