(data stored in ACNUC7421 zone)

HOGENOM: ANOGA_54_PE595

ID   ANOGA_54_PE595                       STANDARD;      PRT;   351 AA.
AC   ANOGA_54_PE595; Q7PKS9; Q8T5K0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (ANOGA_54.PE595).
GN   ORFNames=AGAP001589;
OS   ANOPHELES GAMBIAE.
OC   Anophelinae; Pyretophorus; Pterygota; Protostomia; Pancrustacea;
OC   Panarthropoda; Neoptera; Nematocera; Metazoa; Mandibulata; Insecta;
OC   Hexapoda; Eumetazoa; Eukaryota; Endopterygota; Diptera; Dicondylia;
OC   Culicoidea; Culicimorpha; Culicidae; Coelomata; Bilateria; Arthropoda;
OC   Anopheles.
OX   NCBI_TaxID=7165;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ANOGA_54.PE595.
CC       Anopheles gambiae chromosome 2R_hap_49 AgamP3  sequence 1..61539955
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:MTNA_ANOGA
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAD27760.1; Type=Erroneous gene model prediction;
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Anopheles_gambiae;AGAP001589;AGAP001589-RA;AGAP001589-PA.
DR   EMBL; AAAB01008987; - ;
DR   EMBL; AJ439060; - ;
DR   UniProtKB/Swiss-Prot; Q7PKS9; Q8T5K0; -.
DR   EMBL; AJ439060; CAD27760.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AAAB01008987; EAA43149.1; -; Genomic_DNA.
DR   RefSeq; XP_321518.1; XM_321518.3.
DR   ProteinModelPortal; Q7PKS9; -.
DR   STRING; Q7PKS9; -.
DR   EnsemblMetazoa; AGAP001589-RA; AGAP001589-PA; AGAP001589.
DR   GeneID; 1281584; -.
DR   KEGG; aga:AgaP_AGAP001589; -.
DR   VectorBase; AGAP001589; Anopheles gambiae.
DR   eggNOG; inNOG04539; -.
DR   InParanoid; Q8T5K0; -.
DR   OMA; EDGWKVI; -.
DR   OrthoDB; EOG40P2P9; -.
DR   PhylomeDB; Q7PKS9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; ANOGA_54.PE595; -.
KW   AGAP00158900017784; AGAP001589-PA17508; Q7PKS9; AAAB01008987; AJ439060;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus; Reference proteome.
SQ   SEQUENCE   351 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTLEAIKYKS GQLQILDQLL LPAESKYIPV AGVKDGWSAI HKMQVRGAPA IAIVGCLSLV
     VEIYDKQYET KAALANEIGE HLQYLVTSRP TAVNLKLAAD DVKGQVESLL ANETVTVDGM
     KQEVIKAIEY MLEKDISDNR AIGDNGANVL VKGVDRPLKL LTHCNTGSLA TAGYGTALGV
     IRSVNERNLL EHVYCTETRP YNQGARLTAY ELVHDKLPAT LVTDSMVAAL LNSRKIDAII
     VGADRVAANG DTANKIGTYQ MAVVAKHHGV PFYVAAPFTS IDVAIEDGSH IKIEERPEHE
     LTHIGGQRIA APGIGCWNPA FDVTPAELIT GIITERGVLK PCELAEKVRQ K
//

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