(data stored in ACNUC19888 zone)

HOGENOM: AQAEO1_1_PE1000

ID   AQAEO1_1_PE1000                      STANDARD;      PRT;   356 AA.
AC   AQAEO1_1_PE1000; O67420;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Lipid-A-disaccharide synthase; EC=2.4.1 182;
DE   (AQAEO1_1.PE1000).
GN   Name=lpxB; OrderedLocusNames=aq_1427;
OS   AQUIFEX AEOLICUS VF5.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AQAEO1_1.PE1000.
CC       Aquifex aeolicus VF5, complete genome.
CC       1..8590 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:LPXB_AQUAE
CC   -!- FUNCTION: Condensation of UDP-2,3-diacylglucosamine and 2,3-
CC       diacylglucosamine-1-phosphate to form lipid A disaccharide, a
CC       precursor of lipid A, a phosphorylated glycolipid that anchors the
CC       lipopolysaccharide to the outer membrane of the cell (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
CC       + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate
CC       = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-
CC       2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.
CC   -!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid
CC       IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and
CC       UDP-N-acetyl-alpha-D-glucosamine: step 5/6.
CC   -!- SIMILARITY: Belongs to the lpxB family.
CC   -!- GENE_FAMILY: HOG000018004 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O67420; -.
DR   EMBL; AE000657; AAC07386.1; -; Genomic_DNA.
DR   PIR; B70424; B70424.
DR   RefSeq; NP_213985.1; NC_000918.1.
DR   ProteinModelPortal; O67420; -.
DR   CAZy; GT19; Glycosyltransferase Family 19.
DR   GeneID; 1192951; -.
DR   GenomeReviews; AE000657_GR; aq_1427.
DR   KEGG; aae:aq_1427; -.
DR   NMPDR; fig|224324.1.peg.1000; -.
DR   OMA; IGLANIM; -.
DR   PhylomeDB; O67420; -.
DR   ProtClustDB; CLSK2299698; -.
DR   BioCyc; AAEO224324:AQ_1427-MON; -.
DR   GO; GO:0008915; F:lipid-A-disaccharide synthase activity; IEA:EC.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00392; LpxB; 1; -.
DR   InterPro; IPR003835; Glyco_trans_19.
DR   Pfam; PF02684; LpxB; 1.
DR   TIGRFAMs; TIGR00215; LpxB; 1.
DR   HOGENOMDNA; AQAEO1_1.PE1000; -.
KW   lipid A disaccharide synthetase;
KW   Complete proteome; Glycosyltransferase; Lipid A biosynthesis;
KW   Lipid synthesis; Reference proteome; Transferase.
SQ   SEQUENCE   356 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKKIFLSLAD RSASNYVYEI LKEGFEEYEI YGLTDEKLEK IGVKSVARYS EISTVGLIEA
     LPKVFKFLKI YRKILKNLKN TDTLIACDAP ALNLRLIKDA RKLGVKRIIY FISPQVWAWK
     PKRAEIIANY CDHVIVILPF EKKIYRKFPN LKVHYVGHPL VDLVKPQKTK EEFMKAFKKE
     PLPLLLGSRE GEIRRHVKLL KGIIEELKKS FDVISPTFRE FSKFIERELK VKTLTYEGAS
     YDCFFYSKAS LIASGTASLE AGIAGNPHVV YYKVNPITYF LGKRLVKVPY ISLVNILLKE
     EVVPEFIQKS SDEILKGFEK VYKNEEEIKE KLGTLKFILG ERFVIRKLRE LFLEIV
//

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