(data stored in ACNUC14238 zone)

HOGENOM: AQAEO1_1_PE1002

ID   AQAEO1_1_PE1002                      STANDARD;      PRT;   296 AA.
AC   AQAEO1_1_PE1002; O67422;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=5,10-methylenetetrahydrofolate reductase; EC=1.5.1 20;
DE   (AQAEO1_1.PE1002).
GN   Name=metF; OrderedLocusNames=aq_1429;
OS   AQUIFEX AEOLICUS VF5.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AQAEO1_1.PE1002.
CC       Aquifex aeolicus VF5, complete genome.
CC       1..8590 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:METF_AQUAE
CC   -!- CATALYTIC ACTIVITY: 5-methyltetrahydrofolate + NAD(P)(+) = 5,10-
CC       methylenetetrahydrofolate + NAD(P)H.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC   -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase
CC       family.
CC   -!- GENE_FAMILY: HOG000246233 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O67422; -.
DR   EMBL; AE000657; AAC07387.1; -; Genomic_DNA.
DR   PIR; D70424; D70424.
DR   RefSeq; NP_213987.1; NC_000918.1.
DR   ProteinModelPortal; O67422; -.
DR   GeneID; 1192953; -.
DR   GenomeReviews; AE000657_GR; aq_1429.
DR   KEGG; aae:aq_1429; -.
DR   NMPDR; fig|224324.1.peg.1002; -.
DR   OMA; ITQMFFD; -.
DR   PhylomeDB; O67422; -.
DR   ProtClustDB; CLSK2299700; -.
DR   BioCyc; AAEO224324:AQ_1429-MON; -.
DR   GO; GO:0004489; F:methylenetetrahydrofolate reductase (NADPH) activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR004621; Fadh2_euk.
DR   InterPro; IPR003171; Mehydrof_redctse.
DR   InterPro; IPR004620; MTHF_reductase_bac.
DR   Pfam; PF02219; MTHFR; 1.
DR   TIGRFAMs; TIGR00676; Fadh2; 1.
DR   TIGRFAMs; TIGR00677; Fadh2_euk; 1.
DR   HOGENOMDNA; AQAEO1_1.PE1002; -.
KW   5,10-methylenetetrahydrofolate reductase;
KW   Amino-acid biosynthesis; Complete proteome; FAD; Flavoprotein;
KW   Methionine biosynthesis; NAD; NADP; Oxidoreductase;
KW   Reference proteome.
SQ   SEQUENCE   296 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKIGDILRKG VFSISFEFFP PKTEEGERQL FETIRKLEKL NPTFVSVTYG AGGSTRDRTR
     NIVQKIHEET NLTVMAHLTC IAHTREELID ILQDYKNIGI ENILALRGDV PRDKPDWRPP
     KGACKYAKEL VELIRKEFGD WFSIGVASYP EGHPESPNLE WEVKYFKEKV EAGADFSITQ
     MFFVNDYYYR FVEMCKNAGI DISIIPGIMP ITNFKQIRKF ASLCGATIPQ SLIEKLEKVE
     DKPEEVKKIG IEFAINQCLD LIEHGVPGLH FYTLNKSDAT LKIYEAIKDK IPARST
//

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