(data stored in ACNUC7421 zone)

HOGENOM: AQAEO1_1_PE1463

ID   AQAEO1_1_PE1463                      STANDARD;      PRT;   456 AA.
AC   AQAEO1_1_PE1463; O67879;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase; (AQAEO1_1.PE1463).
GN   Name=mtnA; OrderedLocusNames=aq_2114;
OS   AQUIFEX AEOLICUS VF5.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AQAEO1_1.PE1463.
CC       Aquifex aeolicus VF5, complete genome.
CC       1..8590 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:MTNA_AQUAE
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O67879; -.
DR   EMBL; AE000657; AAC07840.1; -; Genomic_DNA.
DR   PIR; C70481; C70481.
DR   RefSeq; NP_214448.1; NC_000918.1.
DR   ProteinModelPortal; O67879; -.
DR   SMR; O67879; 131-448.
DR   GeneID; 1193868; -.
DR   GenomeReviews; AE000657_GR; aq_2114.
DR   KEGG; aae:aq_2114; -.
DR   NMPDR; fig|224324.1.peg.1463; -.
DR   OMA; RPRNQGA; -.
DR   PhylomeDB; O67879; -.
DR   BioCyc; AAEO224324:AQ_2114-MON; -.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_01678; Salvage_MtnA; 1; fused.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   InterPro; IPR006683; Thioestr_supf.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF03061; 4HBT; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; AQAEO1_1.PE1463; -.
KW   initiation factor eIF-2B alpha subunit;
KW   Amino-acid biosynthesis; Complete proteome; Isomerase;
KW   Methionine biosynthesis; Reference proteome.
SQ   SEQUENCE   456 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDIRTHLGIN QELSGKPVKV AEGYAEVLLK TQESMKADDK GLVHGGFIFS AADYASMLAV
     NHPNVVLAGA NVKFLKPVKV GDEIICKARV SEDKGKKKKV LVECFKGEDK VFEGEFFTVF
     LIDMFWRGEK MEVKPFYWKG DKLLLLDQRK LPHQEVWLEL KTYEEVAKAI KEMAVRGAPA
     IGCTAAYGFV LGVKVQKEDP EKVYETLKNT RPTAYNLFWA LDRMMKALKE GKDIEEEAKE
     IEKEDYEANK RMGEIGSEIV PLNAKVLTHC NTGALATAGW GTALGVIRSA HYGGKNIFVW
     VDETRPYLQG ARLTAWELVK ESIPHKIITD STAGFLMKKG MVDLVIVGAD RITAKGDVAN
     KIGTYTLAVL CKEHNVPFYV AAPTSTIDSN IKSGEEIIIE ERSPEEVKVC GGCAIAPKES
     DALHLAFDIT PAELITGIIT EKGIFKPERI TEALKD
//

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