(data stored in ACNUC30630 zone)

HOGENOM: AQAEO1_1_PE424

ID   AQAEO1_1_PE424                       STANDARD;      PRT;   494 AA.
AC   AQAEO1_1_PE424; O66849;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (AQAEO1_1.PE424).
GN   Name=trpE; OrderedLocusNames=aq_582;
OS   AQUIFEX AEOLICUS VF5.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AQAEO1_1.PE424.
CC       Aquifex aeolicus VF5, complete genome.
CC       1..8590 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:TRPE_AQUAE
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O66849; -.
DR   EMBL; AE000657; AAC06796.1; -; Genomic_DNA.
DR   PIR; E70352; E70352.
DR   RefSeq; NP_213409.1; NC_000918.1.
DR   ProteinModelPortal; O66849; -.
DR   GeneID; 1193267; -.
DR   GenomeReviews; AE000657_GR; aq_582.
DR   KEGG; aae:aq_582; -.
DR   NMPDR; fig|224324.1.peg.424; -.
DR   OMA; RTIYGRA; -.
DR   PhylomeDB; O66849; -.
DR   ProtClustDB; CLSK2299440; -.
DR   BioCyc; AAEO224324:AQ_582-MON; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR005256; Anth_synth_I_PabB.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR00564; TrpE_most; 1.
DR   HOGENOMDNA; AQAEO1_1.PE424; -.
KW   anthranilate synthase component I;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   494 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNLNLSLEEV RKLSENYNVI PLYTELLVDT ETPLSIFLKL KEKGQFNILL ESAEGGEKWG
     RYSFIITGSS FYLRTRKDIG EIYERGKVNF FETKDPLSKI KEVVKKFIPY HDERLPRFWG
     GLVGYFAYDV VKFYEPVEDK NPDPIHTYDI YLVLTDVVVI HDNLTGKIKV VVPIFAQNGI
     EEEYERAKNL IRDTVKKLKE RGTTFLNVVE KEPDFKNWRS NFTKEEFEDI VKKAKEYIAQ
     GDVIQVVLSQ RFRKRFKGNP DNIYRVLRFL NPSPYMYYLD FDQLKVIGSS PEILVRLEEG
     RIETRPIAGT RKRGRTEEED KRLEEDLLSD EKERAEHLML VDLARNDIGR VAKTGSVRVE
     NFMRIERYSH VMHIVSDVVG ELREGYDALD VLKATFPAGT VSGAPKVRAM QIIEELENER
     RGIYAGSVGY ISFQGNMDMA IAIRTAVYRD RDIFVQAGAG IVADSVPEKE WEETVNKAKA
     LMKAIEIAEE SQEE
//

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