(data stored in SCRATCH3701 zone)

HOGENOM6: AQAEO1_1_PE686

ID   AQAEO1_1_PE686                       STANDARD;      PRT;   744 AA.
AC   AQAEO1_1_PE686; O67108;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3; (AQAEO1_1.PE686).
GN   Name=gyrA; OrderedLocusNames=aq_980;
OS   AQUIFEX AEOLICUS VF5.
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS AQAEO1_1.PE686.
CC       Aquifex aeolicus VF5, complete genome.
CC       1..8590 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:GYRA_AQUAE
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings.
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O67108; -.
DR   EMBL; AE000657; AAC07064.1; -; Genomic_DNA.
DR   PIR; A70385; A70385.
DR   RefSeq; NP_213671.1; NC_000918.1.
DR   PDB; 3NO0; X-ray; 1.30 A; A/B/C=494-732.
DR   PDBsum; 3NO0; -.
DR   ProteinModelPortal; O67108; -.
DR   GeneID; 1193742; -.
DR   GenomeReviews; AE000657_GR; aq_980.
DR   KEGG; aae:aq_980; -.
DR   NMPDR; fig|224324.1.peg.686; -.
DR   OMA; VCLKVLG; -.
DR   ProtClustDB; CLSK2299574; -.
DR   BioCyc; AAEO224324:AQ_980-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 3.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   HOGENOMDNA; AQAEO1_1.PE686; -.
DR   PRODOM; AQAEO1_1_PE686.
DR   SWISS-2DPAGE; AQAEO1_1_PE686.
KW   DNA gyrase A subunit;
KW   3D-structure; ATP-binding; Complete proteome; Cytoplasm; DNA-binding;
KW   Isomerase; Nucleotide-binding; Reference proteome; Topoisomerase.
SQ   SEQUENCE   744 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MENRENLVEI PIEEEVKQAY IDYAMSVIVG RAIPDVRDGL KPVQRRILYS MYEMGLLPDK
     PFKKSARIVG ETLGKYHPHG DQAVYEALVR MAQDFTMRYP LIIGQGNFGS IDGDPAAQMR
     YTEAKLSPLA VEMLTDIDKD TVDFQPNFDD TLMEPEVLPS KFPNLLCNGT SGIAVGLATS
     IPPHNLTEVG NALVKLAQNP QISVDEIMEI LKGPDFPTGG VIENFAQVKE IYKTGRGIIK
     VKGKAHVEKV QGGRERIVIT EIPYQVNKAE LIKKIADNVR NGKIKEISDI RDETDKEGIR
     IVVELKRDAK GEEVLKKLYK YTPLEKGFPV NLVVLIDKEP KLVDIKTLLR EFIKHRLEVI
     LRRSKYFLKK VQDRLHIVEG LLKAINFIDD IIERIRRSKD ASEARNYLME EFGLSEKQAQ
     AVLDLRLQRL TSLEREKLLE EEKELREKIE YYKKLVASEG ERIKVFIEET EELVKKYGDK
     RRTFIGGVKE VKEGSITVAV LQDGSIIPVE ELPLEKAPVV NILRVPFTEG LFLVSNRGRV
     YWIAGSQALQ GSKVSLKSRE EKIVGAFIRE KFGNRLLLAT KKGYVKKIPL AEFEYKAQGM
     PIIKLTEGDE VVSIASSVDE THILLFTKKG RVARFSVREV PPSTPGARGV QGIKLEKNDE
     TSGLRIWNGE PYLLVITAKG RVKKISHEEI PKTNRGVKGT EVSGTKDTLV DLIPIKEEVE
     LLITTKNGKA FYGQNQPERH TTFY
//

If you have problems or comments...

PBIL Back to PBIL home page