(data stored in ACNUC16935 zone)

HOGENOM: ARATH_1_PE4129

ID   ARATH_1_PE4129                       STANDARD;      PRT;   156 AA.
AC   ARATH_1_PE4129;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ubiquitin-NEDD8-like protein RUB1;Contains: RecName:
DE   Full=Ubiquitin;Contains: RecName: Full=NEDD8-like protein RUB1; AltName:
DE   Full=Ubiquitin-related protein 1; Short=AtRUB1;Flags: Precursor;
DE   (ARATH_1.PE4129).
GN   Name=RUB1; Synonyms=NEDD8, UBQ15; OrderedLocusNames=At1g31340;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_1.PE4129.
CC       Arabidopsis thaliana chromosome 1 TAIR10 full sequence 1..30427671
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:RUB1_ARATH
CC   -!- FUNCTION: Ubiquitin exists either covalently attached to another
CC       protein, or free (unanchored). When covalently bound, it is
CC       conjugated to target proteins via an isopeptide bond either as a
CC       monomer (monoubiquitin), a polymer linked via different Lys
CC       residues of the ubiquitin (polyubiquitin chains) or a linear
CC       polymer linked via the initiator Met of the ubiquitin (linear
CC       polyubiquitin chains). Polyubiquitin chains, when attached to a
CC       target protein, have different functions depending on the Lys
CC       residue of the ubiquitin that is linked: Lys-11-linked is involved
CC       in ERAD (endoplasmic reticulum-associated degradation) and in
CC       cell-cycle regulation; Lys-29-linked is involved in lysosomal
CC       degradation; Lys-33-linked is involved in kinase modification;
CC       Lys-48-linked is involved in protein degradation via the
CC       proteasome; Lys-63-linked is involved in endocytosis, and DNA-
CC       damage responses. Linear polymer chains formed via attachment by
CC       the initiator Met lead to cell signaling. Ubiquitin is usually
CC       conjugated to Lys residues of target proteins, however, in rare
CC       cases, conjugation to Cys or Ser residues has been observed. When
CC       polyubiquitin is free (unanchored-polyubiquitin), it also has
CC       distinct roles, such as in activation of protein kinases, and in
CC       signaling (By similarity).
CC   -!- FUNCTION: NEDD8-like protein RUB1: Appears to function as a stable
CC       post-translational protein modifier. An AMP-RUB1 intermediate is
CC       formed by an activating enzyme, distinct from the ubiquitin
CC       activating enzyme E1, which is composed of an heterodimer
CC       AXR1/ECR1. Auxin response is mediated, at least in part, through
CC       modification of the cullin AtCUL1 by the attachment of RUB1 to
CC       'Lys-692'.
CC   -!- SUBUNIT: NEDD8-like protein RUB1: Forms a thiol ester with the
CC       heterodimer AXR1/ECR1, specifically with the 'Cys-215' of ECR1.
CC   -!- SUBCELLULAR LOCATION: Ubiquitin: Cytoplasm (By similarity).
CC       Nucleus (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in leaves, stems and flowers.
CC   -!- MISCELLANEOUS: Ubiquitin is encoded by 16 different genes.
CC       Ubiquitin is generally synthesized as a polyubiquitin precursor
CC       with tandem head to tail repeats. Often, there is one to three
CC       additional amino-acids after the last repeat, removed in the
CC       mature protein. Alternatively, ubiquitin extension protein is
CC       synthesized as a single copy of ubiquitin fused to a ribosomal
CC       protein (either L40 or S27A) or to an ubiquitin-related protein
CC       (either RUB1 or RUB2). Following translation, extension protein is
CC       cleaved from ubiquitin.
CC   -!- SIMILARITY: Belongs to the ubiquitin family.
CC   -!- SIMILARITY: Contains 2 ubiquitin-like domains.
CC   -!- GENE_FAMILY: HOG000233942 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT1G31340;AT1G31340.1;AT1G31340.1.
DR   EMBL; AC007654; - ;
DR   EMBL; AK228591; - ;
DR   EMBL; BT005749; - ;
DR   EMBL; BT006110; - ;
DR   UniProtKB/Swiss-Prot; Q9SHE7; O80715; P59263; Q0WQU3; Q38875; Q9LDJ2; Q9LYW1; Q9M0W3; -.
DR   UniProtKB/Swiss-Prot; Q9M1P9; Q9S7X3; -.
DR   EMBL; AC007654; AAF24594.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE31344.1; -; Genomic_DNA.
DR   EMBL; BT005749; AAO64156.1; -; mRNA.
DR   EMBL; BT006110; AAP04095.1; -; mRNA.
DR   EMBL; AK228591; BAF00506.1; -; mRNA.
DR   IPI; IPI00544216; -.
DR   PIR; C86439; C86439.
DR   RefSeq; NP_564379.2; NM_102873.4.
DR   UniGene; At.25337; -.
DR   UniGene; At.30783; -.
DR   UniGene; At.43046; -.
DR   PDB; 1BT0; X-ray; 1.70 A; A=79-152.
DR   PDBsum; 1BT0; -.
DR   ProteinModelPortal; Q9SHE7; -.
DR   SMR; Q9SHE7; 1-149.
DR   STRING; Q9SHE7; -.
DR   PRIDE; Q9SHE7; -.
DR   ProMEX; Q9SHE7; -.
DR   EnsemblPlants; AT1G31340.1; AT1G31340.1; AT1G31340.
DR   GeneID; 840023; -.
DR   GenomeReviews; CT485782_GR; AT1G31340.
DR   KEGG; ath:AT1G31340; -.
DR   TAIR; At1g31340; -.
DR   eggNOG; KOG0001; -.
DR   GeneTree; EPGT00070000028787; -.
DR   PhylomeDB; Q9SHE7; -.
DR   ProtClustDB; CLSN2688712; -.
DR   Genevestigator; Q9SHE7; -.
DR   GermOnline; AT1G31340; Arabidopsis thaliana.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0009790; P:embryo development; IGI:TAIR.
DR   GO; GO:0009693; P:ethylene biosynthetic process; IMP:TAIR.
DR   GO; GO:0045116; P:protein neddylation; TAS:TAIR.
DR   GO; GO:0009733; P:response to auxin stimulus; TAS:TAIR.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_subgr.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 2.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 2.
DR   PROSITE; PS00299; UBIQUITIN_1; 2.
DR   PROSITE; PS50053; UBIQUITIN_2; 2.
DR   HOGENOMDNA; ARATH_1.PE4129; -.
KW   AT1G31340pg.C_scaffold_1320000031; AT1G31340.1.C_scaffold_1320000031;
KW   AC007654; AK228591; BT005749; BT006110;
KW   3D-structure; Complete proteome; Cytoplasm; Isopeptide bond; Nucleus;
KW   Reference proteome; Repeat; Ubl conjugation; Ubl conjugation pathway.
SQ   SEQUENCE   156 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQIFVKTLTG KTITLEVESS DTIDNVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLADYN
     IQKESTLHLV LRLRGGTMIK VKTLTGKEIE IDIEPTDTID RIKERVEEKE GIPPVQQRLI
     YAGKQLADDK TAKDYNIEGG SVLHLVLALR GGFGLL
//

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