(data stored in ACNUC8465 zone)

HOGENOM: ARATH_1_PE5481

ID   ARATH_1_PE5481                       STANDARD;      PRT;   366 AA.
AC   ARATH_1_PE5481; O80397;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mitogen-activated protein kinase kinase 4; Short=AtMKK4;
DE   Short=MAP kinase kinase 4; EC=2.7.12 2; (ARATH_1.PE5481).
GN   Name=MKK4; OrderedLocusNames=At1g51660; ORFNames=F19C24.26;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_1.PE5481.
CC       Arabidopsis thaliana chromosome 1 TAIR10 full sequence 1..30427671
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:M2K4_ARATH
CC   -!- FUNCTION: Involved in the second phase of hydrogen peroxide
CC       generation during hypersensitive response-like cell death.
CC       Involved in the innate immune MAP kinase signaling cascade (MEKK1,
CC       MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin
CC       receptor FLS2. Activates by phosphorylation the downstream MPK3
CC       and MPK6.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated through serine and threonine
CC       phosphorylation by MEKK1.
CC   -!- PTM: Phosphorylated on Thr-224 and Ser-230, which activates the
CC       enzyme.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT1G51660;AT1G51660.1;AT1G51660.1.
DR   EMBL; AB015315; - ;
DR   EMBL; AC025294; - ;
DR   EMBL; AF324667; - ;
DR   EMBL; AF326878; - ;
DR   EMBL; AF349517; - ;
DR   EMBL; AF375398; - ;
DR   EMBL; AY129469; - ;
DR   UniProtKB/Swiss-Prot; O80397; -.
DR   EMBL; AB015315; BAA28830.1; -; mRNA.
DR   EMBL; AC025294; AAG50863.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE32696.1; -; Genomic_DNA.
DR   EMBL; AF324667; AAG40018.1; -; mRNA.
DR   EMBL; AF326878; AAG41460.1; -; mRNA.
DR   EMBL; AF349517; AAK15564.1; -; mRNA.
DR   EMBL; AF375398; AAK52982.1; -; mRNA.
DR   EMBL; AY129469; AAM91055.1; -; mRNA.
DR   IPI; IPI00525732; -.
DR   PIR; T51339; T51339.
DR   RefSeq; NP_175577.1; NM_104044.2.
DR   UniGene; At.351; -.
DR   ProteinModelPortal; O80397; -.
DR   SMR; O80397; 73-354.
DR   IntAct; O80397; 2.
DR   STRING; O80397; -.
DR   PRIDE; O80397; -.
DR   EnsemblPlants; AT1G51660.1; AT1G51660.1; AT1G51660.
DR   GeneID; 841591; -.
DR   GenomeReviews; CT485782_GR; AT1G51660.
DR   KEGG; ath:AT1G51660; -.
DR   NMPDR; fig|3702.1.peg.4640; -.
DR   GeneFarm; 829; 89.
DR   TAIR; At1g51660; -.
DR   eggNOG; KOG0581; -.
DR   GeneTree; EPGT00070000028134; -.
DR   InParanoid; O80397; -.
DR   OMA; INTDLNQ; -.
DR   PhylomeDB; O80397; -.
DR   ProtClustDB; PLN00034; -.
DR   ArrayExpress; O80397; -.
DR   Genevestigator; O80397; -.
DR   GermOnline; AT1G51660; Arabidopsis thaliana.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; IDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009814; P:defense response, incompatible interaction; IMP:TAIR.
DR   GO; GO:0010227; P:floral organ abscission; IMP:TAIR.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   GO; GO:2000038; P:regulation of stomatal complex development; IGI:TAIR.
DR   GO; GO:2000037; P:regulation of stomatal complex patterning; IGI:TAIR.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; ARATH_1.PE5481; -.
KW   AT1G51660pg.C_scaffold_1320000031; AT1G51660.1.C_scaffold_1320000031;
KW   AB015315; AC025294; AF324667; AF326878; AF349517; AF375398; AY129469;
KW   ATP-binding; Complete proteome; Hypersensitive response; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Plant defense; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   366 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRPIQSPPGV SVPVKSRPRR RPDLTLPLPQ RDVSLAVPLP LPPTSGGSGG SSGSAPSSGG
     SASSTNTNSS IEAKNYSDLV RGNRIGSGAG GTVYKVIHRP SSRLYALKVI YGNHEETVRR
     QICREIEILR DVNHPNVVKC HEMFDQNGEI QVLLEFMDKG SLEGAHVWKE QQLADLSRQI
     LSGLAYLHSR HIVHRDIKPS NLLINSAKNV KIADFGVSRI LAQTMDPCNS SVGTIAYMSP
     ERINTDLNQG KYDGYAGDIW SLGVSILEFY LGRFPFPVSR QGDWASLMCA ICMSQPPEAP
     ATASPEFRHF ISCCLQREPG KRRSAMQLLQ HPFILRASPS QNRSPQNLHQ LLPPPRPLSS
     SSSPTT
//

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