(data stored in ACNUC7421 zone)

HOGENOM: ARATH_2_PE588

ID   ARATH_2_PE588                        STANDARD;      PRT;   374 AA.
AC   ARATH_2_PE588; Q9ZUG4; Q8L5B9; Q8LAU5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (ARATH_2.PE588).
GN   OrderedLocusNames=At2g05830; ORFNames=T6P5.3;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_2.PE588.
CC       Arabidopsis thaliana chromosome 2 TAIR10 full sequence 1..19698289
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:MTNA_ARATH
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9ZUG4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9ZUG4-2; Sequence=VSP_040227;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM20446.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT2G05830;AT2G05830.1;AT2G05830.1.
DR   EMBL; AC005970; - ;
DR   EMBL; AY087601; - ;
DR   EMBL; AY099595; - ;
DR   EMBL; AY128839; - ;
DR   EMBL; BX820068; - ;
DR   UniProtKB/Swiss-Prot; Q9ZUG4; Q8L5B9; Q8LAU5; -.
DR   EMBL; AC005970; AAC95160.2; -; Genomic_DNA.
DR   EMBL; CP002685; AEC05975.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC05976.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC05977.1; -; Genomic_DNA.
DR   EMBL; BX820068; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AY087601; AAM65143.1; -; mRNA.
DR   EMBL; AY099595; AAM20446.1; ALT_INIT; mRNA.
DR   EMBL; AY128839; AAM91239.1; -; mRNA.
DR   IPI; IPI00525743; -.
DR   IPI; IPI00543759; -.
DR   PIR; H84471; H84471.
DR   RefSeq; NP_001031339.1; NM_001036262.1.
DR   RefSeq; NP_027726.1; NM_126596.3.
DR   RefSeq; NP_973428.1; NM_201699.1.
DR   UniGene; At.41143; -.
DR   ProteinModelPortal; Q9ZUG4; -.
DR   SMR; Q9ZUG4; 1-367.
DR   IntAct; Q9ZUG4; 3.
DR   STRING; Q9ZUG4; -.
DR   PRIDE; Q9ZUG4; -.
DR   EnsemblPlants; AT2G05830.1; AT2G05830.1; AT2G05830.
DR   GeneID; 815134; -.
DR   GenomeReviews; CT485783_GR; AT2G05830.
DR   KEGG; ath:AT2G05830; -.
DR   TAIR; At2g05830; -.
DR   GeneTree; EPGT00050000007177; -.
DR   InParanoid; Q9ZUG4; -.
DR   OMA; RPRNQGA; -.
DR   PhylomeDB; Q9ZUG4; -.
DR   ProtClustDB; CLSN2687998; -.
DR   Genevestigator; Q9ZUG4; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0071369; P:cellular response to ethylene stimulus; IEP:TAIR.
DR   GO; GO:0071281; P:cellular response to iron ion; IEP:TAIR.
DR   GO; GO:0071732; P:cellular response to nitric oxide; IEP:TAIR.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; ARATH_2.PE588; -.
KW   AT2G05830pg.C_scaffold_1320000031; AT2G05830.1.C_scaffold_1320000031;
KW   AC005970; AY087601; AY099595; AY128839; BX820068;
KW   Alternative splicing; Amino-acid biosynthesis; Complete proteome;
KW   Cytoplasm; Isomerase; Methionine biosynthesis; Nucleus;
KW   Reference proteome.
SQ   SEQUENCE   374 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSGEGDTTLK AICYKPGSLQ LLDQRKLPLE TIYLEIRDAS DGWSAIQEMV VRGAPAIAIA
     AALSLAVEVF NFHGFDGSAS DAVAFLENKL DYLVSSRPTA VNLADAALKL KHVIAKALAT
     ATEAKSIFKA YIEASEDMLE DDVVSNKAIG NFGLSLLRQQ AKNPDKLSVL THCNTGSLAT
     AGYGTALGVI RALHTQGILE RAYCTETRPF NQGSRLTAFE LVHEKIPATL IADSAAAALM
     KDGRVDGVIV GADRVASNGD TANKIGTYSL ALCAKHHGIP FYVAAPLTSV DLSLSSGKEI
     VIEERSPKEL MHTHGGLGER IAAPGISVWN PAFDMTPAEL IAGIITEKGV ITKNGNDTFD
     ISSFAKKITG NSSR
//

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