(data stored in ACNUC8465 zone)

HOGENOM: ARATH_3_PE2885

ID   ARATH_3_PE2885                       STANDARD;      PRT;   348 AA.
AC   ARATH_3_PE2885; Q8RXG3; O80398; Q96517;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mitogen-activated protein kinase kinase 5;
DE   Short=AtMAP2Kalpha; Short=AtMKK5; Short=MAP kinase kinase 5; EC=2.7.12 2;
DE   (ARATH_3.PE2885).
GN   Name=MKK5; OrderedLocusNames=At3g21220; ORFNames=MXL8.8;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_3.PE2885.
CC       Arabidopsis thaliana chromosome 3 TAIR10 full sequence 1..23459830
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:M2K5_ARATH
CC   -!- FUNCTION: Involved in the second phase of hydrogen peroxide
CC       generation during hypersensitive response-like cell death.
CC       Involved in the innate immune MAP kinase signaling cascade (MEKK1,
CC       MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin
CC       receptor FLS2. Activates by phosphorylation the downstream MPK3
CC       and MPK6.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated through serine and threonine
CC       phosphorylation by MEKK1.
CC   -!- TISSUE SPECIFICITY: Expressed in leaves and at lower levels in
CC       roots.
CC   -!- PTM: Phosphorylated on Thr-215 and Ser-221, which activates the
CC       enzyme.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL91161.1; Type=Frameshift; Positions=10;
CC       Sequence=AAM47877.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT3G21220;AT3G21220.1;AT3G21220.1.
DR   EMBL; AB015316; - ;
DR   EMBL; AB023045; - ;
DR   EMBL; AY081272; - ;
DR   EMBL; AY114558; - ;
DR   EMBL; Y07694; - ;
DR   UniProtKB/Swiss-Prot; Q8RXG3; O80398; Q96517; -.
DR   EMBL; AB015316; BAA28831.1; -; mRNA.
DR   EMBL; Y07694; CAA68958.1; -; mRNA.
DR   EMBL; AB023045; BAB01714.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76478.1; -; Genomic_DNA.
DR   EMBL; AY081272; AAL91161.1; ALT_FRAME; mRNA.
DR   EMBL; AY114558; AAM47877.1; ALT_INIT; mRNA.
DR   IPI; IPI00543365; -.
DR   PIR; T51340; T51340.
DR   PIR; T52635; T52635.
DR   RefSeq; NP_188759.1; NM_113017.3.
DR   UniGene; At.24898; -.
DR   UniGene; At.71795; -.
DR   ProteinModelPortal; Q8RXG3; -.
DR   SMR; Q8RXG3; 67-332.
DR   IntAct; Q8RXG3; 1.
DR   STRING; Q8RXG3; -.
DR   PRIDE; Q8RXG3; -.
DR   EnsemblPlants; AT3G21220.1; AT3G21220.1; AT3G21220.
DR   GeneID; 821676; -.
DR   GenomeReviews; BA000014_GR; AT3G21220.
DR   KEGG; ath:AT3G21220; -.
DR   NMPDR; fig|3702.1.peg.14356; -.
DR   GeneFarm; 832; 89.
DR   TAIR; At3g21220; -.
DR   eggNOG; KOG0581; -.
DR   GeneTree; EPGT00070000028134; -.
DR   InParanoid; Q8RXG3; -.
DR   OMA; SAISTNI; -.
DR   PhylomeDB; Q8RXG3; -.
DR   ProtClustDB; PLN00034; -.
DR   ArrayExpress; Q8RXG3; -.
DR   Genevestigator; Q8RXG3; -.
DR   GermOnline; AT3G21220; Arabidopsis thaliana.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009814; P:defense response, incompatible interaction; IMP:TAIR.
DR   GO; GO:0010227; P:floral organ abscission; IMP:TAIR.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR   GO; GO:2000037; P:regulation of stomatal complex patterning; IGI:TAIR.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; ARATH_3.PE2885; -.
KW   AT3G21220pg.C_scaffold_1320000031; AT3G21220.1.C_scaffold_1320000031;
KW   AB015316; AB023045; AY081272; AY114558; Y07694;
KW   ATP-binding; Complete proteome; Hypersensitive response; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Plant defense; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   348 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKPIQSPSGV ASPMKNRLRK RPDLSLPLPH RDVALAVPLP LPPPSSSSSA PASSSAISTN
     ISAAKSLSEL ERVNRIGSGA GGTVYKVIHT PTSRPFALKV IYGNHEDTVR RQICREIEIL
     RSVDHPNVVK CHDMFDHNGE IQVLLEFMDQ GSLEGAHIWQ EQELADLSRQ ILSGLAYLHR
     RHIVHRDIKP SNLLINSAKN VKIADFGVSR ILAQTMDPCN SSVGTIAYMS PERINTDLNH
     GRYDGYAGDV WSLGVSILEF YLGRFPFAVS RQGDWASLMC AICMSQPPEA PATASQEFRH
     FVSCCLQSDP PKRWSAQQLL QHPFILKATG GPNLRQMLPP PRPLPSAS
//

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