(data stored in ACNUC14511 zone)

HOGENOM: ARATH_4_PE2049

ID   ARATH_4_PE2049                       STANDARD;      PRT;   342 AA.
AC   ARATH_4_PE2049; Q43315;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Farnesyl pyrophosphate synthase 2; Short=FPP synthase 2;
DE   Short=FPS 2; EC=2.5.1.10;AltName: Full=(2E,6E)-farnesyl diphosphate
DE   synthase 2;AltName: Full=Dimethylallyltranstransferase 2; EC=2.5.1
DE   1;AltName: Full=Farnesyl diphosphate synthase 2;AltName:
DE   Full=Geranyltranstransferase 2; (ARATH_4.PE2049).
GN   Name=FPS2; OrderedLocusNames=At4g17190; ORFNames=dl4630c;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_4.PE2049.
CC       Arabidopsis thaliana chromosome 4 TAIR10 full sequence 1..18585056
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:FPPS2_ARATH
CC   -!- FUNCTION: Catalyzes the sequential condensation of isopentenyl
CC       pyrophosphate with the allylic pyrophosphates, dimethylallyl
CC       pyrophosphate, and then with the resultant geranylpyrophosphate to
CC       the ultimate product farnesyl pyrophosphate.
CC   -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
CC       diphosphate = diphosphate + geranyl diphosphate.
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + (2E,6E)-farnesyl diphosphate.
CC   -!- COFACTOR: Binds 3 magnesium ions per subunit (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
CC       biosynthesis; farnesyl diphosphate from geranyl diphosphate and
CC       isopentenyl diphosphate: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
CC       biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
CC       and isopentenyl diphosphate: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences;
CC       Name=1;
CC         IsoId=Q43315-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC   -!- GENE_FAMILY: HOG000160912 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT4G17190;AT4G17190.1;AT4G17190.1.
DR   EMBL; AL161545; - ;
DR   EMBL; AY072207; - ;
DR   EMBL; AY117354; - ;
DR   EMBL; L46349; - ;
DR   EMBL; L46350; - ;
DR   EMBL; Z97343; - ;
DR   UniProtKB/Swiss-Prot; Q43315; -.
DR   EMBL; L46350; AAB07247.1; -; Genomic_DNA.
DR   EMBL; L46349; AAB07248.1; -; mRNA.
DR   EMBL; Z97343; CAB10500.1; -; Genomic_DNA.
DR   EMBL; AL161545; CAB80990.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE83860.1; -; Genomic_DNA.
DR   EMBL; AY072207; AAL60028.1; -; mRNA.
DR   EMBL; AY117354; AAM51429.1; -; mRNA.
DR   IPI; IPI00520567; -.
DR   PIR; S71182; S71182.
DR   RefSeq; NP_193452.1; NM_117823.3.
DR   UniGene; At.21195; -.
DR   ProteinModelPortal; Q43315; -.
DR   SMR; Q43315; 1-342.
DR   STRING; Q43315; -.
DR   PRIDE; Q43315; -.
DR   EnsemblPlants; AT4G17190.1; AT4G17190.1; AT4G17190.
DR   GeneID; 827430; -.
DR   GenomeReviews; CT486007_GR; AT4G17190.
DR   KEGG; ath:AT4G17190; -.
DR   NMPDR; fig|3702.1.peg.19505; -.
DR   TAIR; At4g17190; -.
DR   GeneTree; EPGT00050000007584; -.
DR   InParanoid; Q43315; -.
DR   OMA; HEYERES; -.
DR   PhylomeDB; Q43315; -.
DR   ProtClustDB; CLSN2685869; -.
DR   BioCyc; ARA:AT4G17190-MON; -.
DR   BioCyc; MetaCyc:AT4G17190-MON; -.
DR   ArrayExpress; Q43315; -.
DR   Genevestigator; Q43315; -.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:EC.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IGI:TAIR.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0045337; P:farnesyl diphosphate biosynthetic process; IGI:TAIR.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   SUPFAM; SSF48576; Terpenoid_synth; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
DR   HOGENOMDNA; ARATH_4.PE2049; -.
KW   AT4G17190pg.C_scaffold_1320000031; AT4G17190.1.C_scaffold_1320000031;
KW   Q3EA01; AL161545; AY072207; AY117354; L46349; L46350; Z97343;
KW   Alternative splicing; Cholesterol biosynthesis; Complete proteome;
KW   Cytoplasm; Isoprene biosynthesis; Lipid synthesis; Magnesium;
KW   Metal-binding; Reference proteome; Steroid biosynthesis;
KW   Sterol biosynthesis; Transferase.
SQ   SEQUENCE   342 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MADLKSTFLD VYSVLKSDLL QDPSFEFTHE SRQWLERMLD YNVRGGKLNR GLSVVDSYKL
     LKQGQDLTEK ETFLSCALGW CIEWLQAYFL VLDDIMDNSV TRRGQPCWFR KPKVGMIAIN
     DGILLRNHIH RILKKHFREM PYYVDLVDLF NEVEFQTACG QMIDLITTFD GEKDLSKYSL
     QIHRRIVEYK TAYYSFYLPV ACALLMAGEN LENHTDVKTV LVDMGIYFQV QDDYLDCFAD
     PETLGKIGTD IEDFKCSWLV VKALERCSEE QTKILYENYG KAEPSNVAKV KALYKELDLE
     GAFMEYEKES YEKLTKLIEA HQSKAIQAVL KSFLAKIYKR QK
//

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