(data stored in ACNUC8465 zone)

HOGENOM: ARATH_4_PE3341

ID   ARATH_4_PE3341                       STANDARD;      PRT;   354 AA.
AC   ARATH_4_PE3341; Q94A06; O04440; O04661;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mitogen-activated protein kinase kinase 1; Short=MAP kinase
DE   kinase 1; EC=2.7.12 2;AltName: Full=AtMEK1;AltName: Full=NMAPKK;
DE   (ARATH_4.PE3341).
GN   Name=MKK1; Synonyms=MEK1; OrderedLocusNames=At4g26070;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_4.PE3341.
CC       Arabidopsis thaliana chromosome 4 TAIR10 full sequence 1..18585056
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:M2K1_ARATH
CC   -!- FUNCTION: May be involved in the cold and salinity stress-mediated
CC       MAP kinase signaling cascade (MEKK1, MEK1/MKK2 and MPK4/MPK6).
CC       Phosphorylates MPK4 in vitro.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated through serine and threonine
CC       phosphorylation in response to wounding, cold, drought, salt
CC       stresses, hydrogen peroxide, bacterial flagellin and laminarin
CC       beta-glucan.
CC   -!- SUBUNIT: Interacts with MEKK1 (MAPKKK) and MPK4. May form a
CC       ternary complex with.
CC   -!- INTERACTION:
CC       Q9LMM5:MPK11; NbExp=2; IntAct=EBI-994464, EBI-2358699;
CC       Q8GYQ5:MPK12; NbExp=2; IntAct=EBI-994464, EBI-2128461;
CC       Q39024:MPK4; NbExp=5; IntAct=EBI-994464, EBI-994375;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q94A06-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q94A06-2; Sequence=VSP_019782, VSP_019783;
CC         Note=May be due to an intron retention. No experimental
CC         confirmation available;
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stem, flowers and
CC       siliques.
CC   -!- INDUCTION: By wounding.
CC   -!- PTM: Phosphorylated on Thr-218 and Ser-224, which activates the
CC       enzyme.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT4G26070;AT4G26070.3;AT4G26070.3.
DR   EMBL; AB004796; - ;
DR   EMBL; AF000977; - ;
DR   EMBL; AL049483; - ;
DR   EMBL; AL161564; - ;
DR   EMBL; AY050774; - ;
DR   EMBL; AY087065; - ;
DR   EMBL; BT001935; - ;
DR   UniProtKB/Swiss-Prot; Q94A06; O04440; O04661; -.
DR   EMBL; AF000977; AAB97145.1; -; mRNA.
DR   EMBL; AB004796; BAA24079.1; -; mRNA.
DR   EMBL; AL049483; CAB39672.1; -; Genomic_DNA.
DR   EMBL; AL161564; CAB79462.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE85152.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE85153.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE85154.1; -; Genomic_DNA.
DR   EMBL; AY050774; AAK92709.1; -; mRNA.
DR   EMBL; BT001935; AAN71934.1; -; mRNA.
DR   EMBL; AY087065; AAM64626.1; -; mRNA.
DR   IPI; IPI00532526; -.
DR   IPI; IPI00532754; -.
DR   PIR; T04262; T04262.
DR   RefSeq; NP_194337.1; NM_118740.2.
DR   RefSeq; NP_849446.1; NM_179115.1.
DR   RefSeq; NP_974619.1; NM_202890.1.
DR   UniGene; At.21332; -.
DR   UniGene; At.223; -.
DR   ProteinModelPortal; Q94A06; -.
DR   SMR; Q94A06; 63-344.
DR   IntAct; Q94A06; 4.
DR   STRING; Q94A06; -.
DR   PRIDE; Q94A06; -.
DR   EnsemblPlants; AT4G26070.2; AT4G26070.2; AT4G26070.
DR   EnsemblPlants; AT4G26070.3; AT4G26070.3; AT4G26070.
DR   GeneID; 828713; -.
DR   GenomeReviews; CT486007_GR; AT4G26070.
DR   KEGG; ath:AT4G26070; -.
DR   NMPDR; fig|3702.1.peg.20524; -.
DR   GeneFarm; 883; 89.
DR   TAIR; At4g26070; -.
DR   eggNOG; KOG0581; -.
DR   GeneTree; EPGT00070000029225; -.
DR   InParanoid; Q94A06; -.
DR   OMA; HHERRII; -.
DR   PhylomeDB; Q94A06; -.
DR   ProtClustDB; CLSN2685391; -.
DR   Genevestigator; Q94A06; -.
DR   GermOnline; AT4G26070; Arabidopsis thaliana.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:TAIR.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IDA:TAIR.
DR   GO; GO:0009814; P:defense response, incompatible interaction; IGI:TAIR.
DR   GO; GO:0042542; P:response to hydrogen peroxide; IDA:TAIR.
DR   GO; GO:0002237; P:response to molecule of bacterial origin; IDA:TAIR.
DR   GO; GO:0009414; P:response to water deprivation; IMP:TAIR.
DR   GO; GO:0009611; P:response to wounding; IEP:TAIR.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; ARATH_4.PE3341; -.
KW   AT4G26070pg.C_scaffold_1320000031; AT4G26070.3.C_scaffold_1320000031;
KW   AB004796; AF000977; AL049483; AL161564; AY050774; AY087065; BT001935;
KW   Alternative splicing; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   354 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNRGSLCPNP ICLPPLEQSI SKFLTQSGTF KDGDLRVNKD GIQTVSLSEP GAPPPIEPLD
     NQLSLADLEV IKVIGKGSSG NVQLVKHKLT QQFFALKVIQ LNTEESTCRA ISQELRINLS
     SQCPYLVSCY QSFYHNGLVS IILEFMDGGS LADLLKKVGK VPENMLSAIC KRVLRGLCYI
     HHERRIIHRD LKPSNLLINH RGEVKITDFG VSKILTSTSS LANSFVGTYP YMSPERISGS
     LYSNKSDIWS LGLVLLECAT GKFPYTPPEH KKGWSSVYEL VDAIVENPPP CAPSNLFSPE
     FCSFISQCVQ KDPRDRKSAK ELLEHKFVKM FEDSDTNLSA YFTDAGSLIP PLAN
//

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