(data stored in ACNUC8465 zone)

HOGENOM: ARATH_4_PE3870

ID   ARATH_4_PE3870                       STANDARD;      PRT;   363 AA.
AC   ARATH_4_PE3870; Q9S7U9; O80395;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mitogen-activated protein kinase kinase 2;
DE   Short=AtMAP2Kbeta; Short=AtMKK2; Short=MAP kinase kinase 2; EC=2.7.12 2;
DE   (ARATH_4.PE3870).
GN   Name=MKK2; Synonyms=MAP2K, MK1; OrderedLocusNames=At4g29810;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_4.PE3870.
CC       Arabidopsis thaliana chromosome 4 TAIR10 full sequence 1..18585056
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:M2K2_ARATH
CC   -!- FUNCTION: May be involved in the cold and salinity stress-mediated
CC       MAP kinase signaling cascade (MEKK1, MEK1/MKK2 and MPK4/MPK6).
CC       Activates by phosphorylation the downstream MPK4 and MPK6.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated in response to cold and salt stresses
CC       through serine and threonine phosphorylation by MEKK1.
CC   -!- SUBUNIT: Interacts with MEKK1, MPK4 and MPK6.
CC   -!- INTERACTION:
CC       Q9M1Z5:MPK10; NbExp=2; IntAct=EBI-994350, EBI-2358527;
CC       Q9LMM5:MPK11; NbExp=2; IntAct=EBI-994350, EBI-2358699;
CC       Q9LQQ9:MPK13; NbExp=2; IntAct=EBI-994350, EBI-2358762;
CC       Q39024:MPK4; NbExp=4; IntAct=EBI-994350, EBI-994375;
CC       Q39026:MPK6; NbExp=4; IntAct=EBI-994350, EBI-349548;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q9S7U9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9S7U9-2; Sequence=VSP_019784;
CC         Note=May be due to intron retention. No experimental
CC         confirmation available;
CC   -!- PTM: Phosphorylated on Thr-220 and Thr-226, which activates the
CC       enzyme.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT4G29810;AT4G29810.1;AT4G29810.1.
DR   EMBL; AB015313; - ;
DR   EMBL; AF067792; - ;
DR   EMBL; AF385688; - ;
DR   EMBL; AJ006871; - ;
DR   EMBL; AL050352; - ;
DR   EMBL; AL161575; - ;
DR   EMBL; AY078009; - ;
DR   UniProtKB/Swiss-Prot; Q9S7U9; O80395; -.
DR   EMBL; AB015313; BAA28828.1; -; mRNA.
DR   EMBL; AJ006871; CAA07281.1; -; mRNA.
DR   EMBL; AF067792; AAC72754.1; -; mRNA.
DR   EMBL; AL050352; CAB43656.1; -; Genomic_DNA.
DR   EMBL; AL161575; CAB79739.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE85679.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE85680.1; -; Genomic_DNA.
DR   EMBL; AF385688; AAK60281.1; -; mRNA.
DR   EMBL; AY078009; AAL77710.1; -; mRNA.
DR   IPI; IPI00520140; -.
DR   IPI; IPI00656994; -.
DR   PIR; T08542; T08542.
DR   PIR; T51735; T51735.
DR   RefSeq; NP_001031751.1; NM_001036674.1.
DR   RefSeq; NP_194710.1; NM_119127.3.
DR   UniGene; At.1001; -.
DR   UniGene; At.24272; -.
DR   ProteinModelPortal; Q9S7U9; -.
DR   SMR; Q9S7U9; 65-347.
DR   IntAct; Q9S7U9; 6.
DR   STRING; Q9S7U9; -.
DR   PRIDE; Q9S7U9; -.
DR   ProMEX; Q9S7U9; -.
DR   EnsemblPlants; AT4G29810.1; AT4G29810.1; AT4G29810.
DR   GeneID; 829103; -.
DR   GenomeReviews; CT486007_GR; AT4G29810.
DR   KEGG; ath:AT4G29810; -.
DR   NMPDR; fig|3702.1.peg.20954; -.
DR   GeneFarm; 887; 89.
DR   TAIR; At4g29810; -.
DR   GeneTree; EPGT00070000029225; -.
DR   InParanoid; Q9S7U9; -.
DR   OMA; KVIQLNI; -.
DR   PhylomeDB; Q9S7U9; -.
DR   ProtClustDB; CLSN2685391; -.
DR   Genevestigator; Q9S7U9; -.
DR   GermOnline; AT4G29810; Arabidopsis thaliana.
DR   GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR   GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:TAIR.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009631; P:cold acclimation; IMP:TAIR.
DR   GO; GO:0009814; P:defense response, incompatible interaction; IGI:TAIR.
DR   GO; GO:0000165; P:MAPKKK cascade; IGI:TAIR.
DR   GO; GO:0009651; P:response to salt stress; IDA:TAIR.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; ARATH_4.PE3870; -.
KW   AT4G29810pg.C_scaffold_1320000031; AT4G29810.1.C_scaffold_1320000031;
KW   AB015313; AF067792; AF385688; AJ006871; AL050352; AL161575; AY078009;
KW   Alternative splicing; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   363 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKKGGFSNNL KLAIPVAGEQ SITKFLTQSG TFKDGDLRVN KDGVRIISQL EPEVLSPIKP
     ADDQLSLSDL DMVKVIGKGS SGVVQLVQHK WTGQFFALKV IQLNIDEAIR KAIAQELKIN
     QSSQCPNLVT SYQSFYDNGA ISLILEYMDG GSLADFLKSV KAIPDSYLSA IFRQVLQGLI
     YLHHDRHIIH RDLKPSNLLI NHRGEVKITD FGVSTVMTNT AGLANTFVGT YNYMSPERIV
     GNKYGNKSDI WSLGLVVLEC ATGKFPYAPP NQEETWTSVF ELMEAIVDQP PPALPSGNFS
     PELSSFISTC LQKDPNSRSS AKELMEHPFL NKYDYSGINL ASYFTDAGSP LATLGNLSGT
     FSV
//

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