(data stored in ACNUC21049 zone)

HOGENOM: ARATH_4_PE706

ID   ARATH_4_PE706                        STANDARD;      PRT;   1088 AA.
AC   ARATH_4_PE706; Q9M0V3; Q0WL42; Q8VY31;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA damage-binding protein 1a;AltName: Full=UV-damaged
DE   DNA-binding protein 1a; Short=DDB1a; (ARATH_4.PE706).
GN   Name=DDB1A; OrderedLocusNames=At4g05420; ORFNames=C6L9.100;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_4.PE706.
CC       Arabidopsis thaliana chromosome 4 TAIR10 full sequence 1..18585056
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:DDB1A_ARATH
CC   -!- FUNCTION: Component of light signal transduction machinery.
CC       Involved in repression of photomorphogenesis in darkness by
CC       participating in the CDD complex, a complex probably required to
CC       regulate the activity of ubiquitin conjugating enzymes (E2s).
CC       Repression of photomorphogenesis is probably mediated by
CC       ubiquitination and subsequent degradation of photomorphogenesis-
CC       promoting factors such as HY5, HYH and LAF1. Plays a role in DNA
CC       repair by forming with DDB2 the UV-damaged DNA-binding protein
CC       complex (UV-DDB). Component of the CUL4-RBX1-DDB1-PRL1 E3
CC       ubiquitin-protein ligase complex.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Component of the CDD complex, at least composed of DET1,
CC       COP10 and DDB1A. Component of the CUL4-RBX1-CDD complex. Component
CC       of the CUL4-RBX1-DDB1-PRL1 E3 ubiquitin-protein ligase complex.
CC       Component of the UV-DDB complex, which is composed of DDB1A and
CC       DDB2.
CC   -!- INTERACTION:
CC       Q8H177:At1g65030; NbExp=2; IntAct=EBI-1632780, EBI-1632868;
CC       Q9LJD7:COP10; NbExp=5; IntAct=EBI-1632780, EBI-2429853;
CC       Q8LGH4:CUL4; NbExp=11; IntAct=EBI-1632780, EBI-541750;
CC       Q9M086:DCAF1; NbExp=6; IntAct=EBI-1632780, EBI-2429941;
CC       Q8L4M1:DWA1; NbExp=2; IntAct=EBI-1632780, EBI-941035;
CC       Q9SZQ5:F27B13.70; NbExp=2; IntAct=EBI-1632780, EBI-1632819;
CC       Q9M1E5:F9K21.200; NbExp=2; IntAct=EBI-1632780, EBI-1632891;
CC       O22469:MSI3; NbExp=2; IntAct=EBI-1632780, EBI-1632794;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates to the
CC       nucleus upon exposure to UV.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences;
CC       Name=1;
CC         IsoId=Q9M0V3-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the DDB1 family.
CC   -!- WEB RESOURCE: Name=PlantsUBQ; Note=A functional genomics database
CC       for the ubiquitin/26S proteasome proteolytic pathway in plants;
CC       URL="http://plantsubq.genomics.purdue.edu/";
CC   -!- GENE_FAMILY: HOG000007241 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT4G05420;AT4G05420.1;AT4G05420.1.
DR   EMBL; AK230366; - ;
DR   EMBL; AL161503; - ;
DR   EMBL; AY074257; - ;
DR   EMBL; BT001905; - ;
DR   UniProtKB/Swiss-Prot; Q9M0V3; Q0WL42; Q8VY31; -.
DR   EMBL; AL161503; CAB81084.1; -; Genomic_DNA.
DR   EMBL; CP002687; AEE82517.1; -; Genomic_DNA.
DR   EMBL; AY074257; AAL66955.1; -; mRNA.
DR   EMBL; BT001905; AAN71904.1; -; mRNA.
DR   EMBL; AK230366; BAF02165.1; -; mRNA.
DR   IPI; IPI00548104; -.
DR   PIR; B85068; B85068.
DR   RefSeq; NP_192451.1; NM_116781.2.
DR   UniGene; At.32663; -.
DR   UniGene; At.47587; -.
DR   ProteinModelPortal; Q9M0V3; -.
DR   IntAct; Q9M0V3; 16.
DR   STRING; Q9M0V3; -.
DR   PRIDE; Q9M0V3; -.
DR   ProMEX; Q9M0V3; -.
DR   EnsemblPlants; AT4G05420.1; AT4G05420.1; AT4G05420.
DR   GeneID; 825890; -.
DR   GenomeReviews; CT486007_GR; AT4G05420.
DR   KEGG; ath:AT4G05420; -.
DR   NMPDR; fig|3702.1.peg.18366; -.
DR   GeneFarm; 4660; 457.
DR   TAIR; At4g05420; -.
DR   GeneTree; EPGT00070000029701; -.
DR   InParanoid; Q9M0V3; -.
DR   OMA; CALGDGS; -.
DR   PhylomeDB; Q9M0V3; -.
DR   ProtClustDB; CLSN2685347; -.
DR   ArrayExpress; Q9M0V3; -.
DR   Genevestigator; Q9M0V3; -.
DR   GermOnline; AT4G05420; Arabidopsis thaliana.
DR   GO; GO:0080008; C:CUL4 RING ubiquitin ligase complex; IPI:TAIR.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0010100; P:negative regulation of photomorphogenesis; IGI:TAIR.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-dependent; IPI:TAIR.
DR   GO; GO:0009585; P:red, far-red light phototransduction; IEA:UniProtKB-KW.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   InterPro; IPR011046; WD40_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 2.
DR   Pfam; PF03178; CPSF_A; 1.
DR   SUPFAM; SSF50978; WD40_like; 1.
DR   HOGENOMDNA; ARATH_4.PE706; -.
KW   AT4G05420pg.C_scaffold_1320000031; AT4G05420.1.C_scaffold_1320000031;
KW   AK230366; AL161503; AY074257; BT001905;
KW   Alternative splicing; Complete proteome; Cytoplasm; DNA damage;
KW   DNA repair; DNA-binding; Nucleus; Phytochrome signaling pathway;
KW   Reference proteome; Ubl conjugation pathway.
SQ   SEQUENCE   1088 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSWNYVVTA HKPTSVTHSC VGNFTSPQEL NLIVAKCTRI EIHLLTPQGL QPMLDVPIYG
     RIATLELFRP HGEAQDFLFI ATERYKFCVL QWDPESSELI TRAMGDVSDR IGRPTDNGQI
     GIIDPDCRLI GLHLYDGLFK VIPFDNKGQL KEAFNIRLEE LQVLDIKFLF GCAKPTIAVL
     YQDNKDARHV KTYEVSLKDK DFVEGPWSQN SLDNGADLLI PVPPPLCGVL IIGEETIVYC
     SASAFKAIPI RPSITKAYGR VDVDGSRYLL GDHAGMIHLL VITHEKEKVT GLKIELLGET
     SIASTISYLD NAVVFVGSSY GDSQLVKLNL HPDAKGSYVE VLERYINLGP IVDFCVVDLE
     RQGQGQVVTC SGAFKDGSLR VVRNGIGINE QASVELQGIK GMWSLKSSID EAFDTFLVVS
     FISETRILAM NLEDELEETE IEGFLSQVQT LFCHDAVYNQ LVQVTSNSVR LVSSTTRELR
     DEWHAPAGFT VNVATANASQ VLLATGGGHL VYLEIGDGKL TEVQHALLEY EVSCLDINPI
     GDNPNYSQLA AVGMWTDISV RIFSLPELTL ITKEQLGGEI IPRSVLLCAF EGISYLLCAL
     GDGHLLNFQM DTTTGQLKDR KKVSLGTQPI TLRTFSSKSA THVFAASDRP TVIYSSNKKL
     LYSNVNLKEV SHMCPFNSAA FPDSLAIARE GELTIGTIDD IQKLHIRTIP LGEHARRICH
     QEQTRTFGIC SLGNQSNSEE SEMHFVRLLD DQTFEFMSTY PLDSFEYGCS ILSCSFTEDK
     NVYYCVGTAY VLPEENEPTK GRILVFIVED GRLQLIAEKE TKGAVYSLNA FNGKLLAAIN
     QKIQLYKWML RDDGTRELQS ECGHHGHILA LYVQTRGDFI VVGDLMKSIS LLLYKHEEGA
     IEERARDYNA NWMSAVEILD DDIYLGAENN FNLLTVKKNS EGATDEERGR LEVVGEYHLG
     EFVNRFRHGS LVMRLPDSEI GQIPTVIFGT VNGVIGVIAS LPQEQYTFLE KLQSSLRKVI
     KGVGGLSHEQ WRSFNNEKRT AEARNFLDGD LIESFLDLSR NKMEDISKSM NVQVEELCKR
     VEELTRLH
//

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