(data stored in ACNUC10083 zone)

HOGENOM: ARATH_5_PE4332

ID   ARATH_5_PE4332                       STANDARD;      PRT;   775 AA.
AC   ARATH_5_PE4332; P92941; O64990; Q93YS0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein CLC-a; Short=AtCLC-a;AltName:
DE   Full=CBS domain-containing protein CBSCLC5; (ARATH_5.PE4332).
GN   Name=CLC-A; Synonyms=CBSCLC5; OrderedLocusNames=At5g40890;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_5.PE4332.
CC       Arabidopsis thaliana chromosome 5 TAIR10 full sequence 1..26975502
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:CLCA_ARATH
CC   -!- FUNCTION: Voltage-gated chloride channel that could play a role in
CC       the regulation of nitrate content.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences;
CC       Name=1;
CC         IsoId=P92941-1; Sequence=Displayed;
CC   -!- TISSUE SPECIFICITY: Broadly expressed in the plant.
CC   -!- INDUCTION: In shoots and roots by nitrate treatment.
CC   -!- MISCELLANEOUS: Loss-of-function mutation clca-1 leads to an
CC       altered nitrate content and hypersensitivity to chlorate.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231081 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT5G40890;AT5G40890.1;AT5G40890.1.
DR   EMBL; AB011477; - ;
DR   EMBL; AF044313; - ;
DR   EMBL; AY059791; - ;
DR   EMBL; AY150506; - ;
DR   EMBL; U72151; - ;
DR   EMBL; Z71445; - ;
DR   UniProtKB/Swiss-Prot; P92941; O64990; Q93YS0; -.
DR   EMBL; Z71445; CAA96057.1; -; mRNA.
DR   EMBL; AF044313; AAC05742.1; -; mRNA.
DR   EMBL; AB011477; BAB11351.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED94612.1; -; Genomic_DNA.
DR   EMBL; AY059791; AAL24139.1; -; mRNA.
DR   EMBL; AY150506; AAN13022.1; -; mRNA.
DR   IPI; IPI00546958; -.
DR   PIR; T52107; T52107.
DR   RefSeq; NP_198905.1; NM_123454.2.
DR   UniGene; At.25457; -.
DR   ProteinModelPortal; P92941; -.
DR   SMR; P92941; 597-650, 705-755.
DR   STRING; P92941; -.
DR   PRIDE; P92941; -.
DR   EnsemblPlants; AT5G40890.1; AT5G40890.1; AT5G40890.
DR   GeneID; 834090; -.
DR   GenomeReviews; BA000015_GR; AT5G40890.
DR   KEGG; ath:AT5G40890; -.
DR   GeneFarm; 2831; 272.
DR   TAIR; At5g40890; -.
DR   eggNOG; KOG0474; -.
DR   InParanoid; P92941; -.
DR   OMA; SIYEIIL; -.
DR   PhylomeDB; P92941; -.
DR   ProtClustDB; CLSN2684995; -.
DR   ArrayExpress; P92941; -.
DR   Genevestigator; P92941; -.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; TAS:TAIR.
DR   GO; GO:0015112; F:nitrate transmembrane transporter activity; IDA:TAIR.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0010167; P:response to nitrate; IMP:TAIR.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002251; Cl_channel_pln.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01120; CLCHANNELPLT.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; ARATH_5.PE4332; -.
KW   AT5G40890pg.C_scaffold_1320000031; AT5G40890.10C_scaffold_1320000031;
KW   Q2V324; Q96325; AB011477; AF044313; AY059791; AY150506; U72151; Z71445;
KW   Alternative splicing; CBS domain; Chloride; Chloride channel;
KW   Complete proteome; Ion transport; Ionic channel; Membrane;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
SQ   SEQUENCE   775 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDEDGNLQIS NSNYNGEEEG EDPENNTLNQ PLLKRHRTLS STPLALVGAK VSHIESLDYE
     INENDLFKHD WRSRSKAQVF QYIFLKWTLA CLVGLFTGLI ATLINLAVEN IAGYKLLAVG
     YYIAQDRFWT GLMVFTGANL GLTLVATVLV VYFAPTAAGP GIPEIKAYLN GIDTPNMFGF
     TTMMVKIVGS IGAVAAGLDL GKEGPLVHIG SCIASLLGQG GPDNHRIKWR WLRYFNNDRD
     RRDLITCGSA SGVCAAFRSP VGGVLFALEE VATWWRSALL WRTFFSTAVV VVVLRAFIEI
     CNSGKCGLFG SGGLIMFDVS HVEVRYHAAD IIPVTLIGVF GGILGSLYNH LLHKVLRLYN
     LINQKGKIHK VLLSLGVSLF TSVCLFGLPF LAECKPCDPS IDEICPTNGR SGNFKQFNCP
     NGYYNDLSTL LLTTNDDAVR NIFSSNTPNE FGMVSLWIFF GLYCILGLIT FGIATPSGLF
     LPIILMGSAY GRMLGTAMGS YTNIDQGLYA VLGAASLMAG SMRMTVSLCV IFLELTNNLL
     LLPITMFVLL IAKTVGDSFN LSIYEIILHL KGLPFLEANP EPWMRNLTVG ELNDAKPPVV
     TLNGVEKVAN IVDVLRNTTH NAFPVLDGAD QNTGTELHGL ILRAHLVKVL KKRWFLNEKR
     RTEEWEVREK FTPVELAERE DNFDDVAITS SEMQLYVDLH PLTNTTPYTV VQSMSVAKAL
     VLFRSVGLRH LLVVPKIQAS GMSPVIGILT RQDLRAYNIL QAFPHLDKHK SGKAR
//

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