(data stored in ACNUC14511 zone)

HOGENOM: ARATH_5_PE5289

ID   ARATH_5_PE5289                       STANDARD;      PRT;   384 AA.
AC   ARATH_5_PE5289; Q09152; Q42573; Q8W504; Q93Y84;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Farnesyl pyrophosphate synthase 1, mitochondrial; Short=FPP
DE   synthase 1; Short=FPS 1; EC=2.5.1.10;AltName: Full=(2E,6E)-farnesyl
DE   diphosphate synthase 1;AltName: Full=Dimethylallyltranstransferase 1;
DE   EC=2.5.1 1;AltName: Full=Farnesyl diphosphate synthase 1;AltName:
DE   Full=Geranyltranstransferase 1;Flags: Precursor; (ARATH_5.PE5289).
GN   Name=FPS1; OrderedLocusNames=At5g47770; ORFNames=MCA23.9;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_5.PE5289.
CC       Arabidopsis thaliana chromosome 5 TAIR10 full sequence 1..26975502
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:FPPS1_ARATH
CC   -!- FUNCTION: Catalyzes the sequential condensation of isopentenyl
CC       pyrophosphate with the allylic pyrophosphates, dimethylallyl
CC       pyrophosphate, and then with the resultant geranylpyrophosphate to
CC       the ultimate product farnesyl pyrophosphate.
CC   -!- CATALYTIC ACTIVITY: Dimethylallyl diphosphate + isopentenyl
CC       diphosphate = diphosphate + geranyl diphosphate.
CC   -!- CATALYTIC ACTIVITY: Geranyl diphosphate + isopentenyl diphosphate
CC       = diphosphate + (2E,6E)-farnesyl diphosphate.
CC   -!- COFACTOR: Binds 3 magnesium ions per subunit (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate
CC       biosynthesis; farnesyl diphosphate from geranyl diphosphate and
CC       isopentenyl diphosphate: step 1/1.
CC   -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate
CC       biosynthesis; geranyl diphosphate from dimethylallyl diphosphate
CC       and isopentenyl diphosphate: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion. Cytoplasm.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=Mitochondrial; Synonyms=FPS1L;
CC         IsoId=Q09152-1; Sequence=Displayed;
CC       Name=Cytoplasmic; Synonyms=FPS1S;
CC         IsoId=Q09152-2; Sequence=VSP_018808;
CC   -!- TISSUE SPECIFICITY: The FPS1L mRNA accumulates preferentially in
CC       inflorescences, whereas the FPS1S mRNA is predominantly expressed
CC       in roots and inflorescences.
CC   -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC   -!- GENE_FAMILY: HOG000160912 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT5G47770;AT5G47770.1;AT5G47770.1.
DR   EMBL; AB016886; - ;
DR   EMBL; AF370324; - ;
DR   EMBL; AY063112; - ;
DR   EMBL; L46367; - ;
DR   EMBL; U80605; - ;
DR   EMBL; X75789; - ;
DR   UniProtKB/Swiss-Prot; Q09152; Q42573; Q8W504; Q93Y84; -.
DR   EMBL; U80605; AAB49290.1; -; mRNA.
DR   EMBL; L46367; AAF44787.1; -; Genomic_DNA.
DR   EMBL; L46367; AAB07264.1; -; Genomic_DNA.
DR   EMBL; AB016886; BAB11324.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED95570.1; -; Genomic_DNA.
DR   EMBL; AF370324; AAK44139.1; -; mRNA.
DR   EMBL; AY063112; AAL34286.1; -; mRNA.
DR   EMBL; X75789; CAA53433.1; -; mRNA.
DR   IPI; IPI00548843; -.
DR   IPI; IPI00760338; -.
DR   PIR; S52009; S52009.
DR   RefSeq; NP_199588.1; NM_124151.2.
DR   UniGene; At.21206; -.
DR   ProteinModelPortal; Q09152; -.
DR   SMR; Q09152; 43-384.
DR   STRING; Q09152; -.
DR   PRIDE; Q09152; -.
DR   EnsemblPlants; AT5G47770.1; AT5G47770.1; AT5G47770.
DR   GeneID; 834828; -.
DR   GenomeReviews; BA000015_GR; AT5G47770.
DR   KEGG; ath:AT5G47770; -.
DR   NMPDR; fig|3702.1.peg.26592; -.
DR   TAIR; At5g47770; -.
DR   eggNOG; KOG0711; -.
DR   GeneTree; EPGT00050000007584; -.
DR   InParanoid; Q09152; -.
DR   OMA; ENKTSHY; -.
DR   PhylomeDB; Q09152; -.
DR   ProtClustDB; CLSN2685869; -.
DR   BioCyc; ARA:AT5G47770-MON; -.
DR   BioCyc; MetaCyc:AT5G47770-MON; -.
DR   ArrayExpress; Q09152; -.
DR   Genevestigator; Q09152; -.
DR   GermOnline; AT5G47770; Arabidopsis thaliana.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0004161; F:dimethylallyltranstransferase activity; IEA:EC.
DR   GO; GO:0004337; F:geranyltranstransferase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000092; Polyprenyl_synt.
DR   InterPro; IPR008949; Terpenoid_synth.
DR   Gene3D; G3DSA:1.10.600.10; Terpenoid_synth; 1.
DR   Pfam; PF00348; polyprenyl_synt; 1.
DR   SUPFAM; SSF48576; Terpenoid_synth; 1.
DR   PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR   PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
DR   HOGENOMDNA; ARATH_5.PE5289; -.
KW   AT5G47770pg.C_scaffold_1320000031; AT5G47770.10C_scaffold_1320000031;
KW   AB016886; AF370324; AY063112; L46367; U80605; X75789;
KW   Alternative initiation; Cholesterol biosynthesis; Complete proteome;
KW   Cytoplasm; Isoprene biosynthesis; Lipid synthesis; Magnesium;
KW   Metal-binding; Mitochondrion; Reference proteome;
KW   Steroid biosynthesis; Sterol biosynthesis; Transferase;
KW   Transit peptide.
SQ   SEQUENCE   384 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSVSCCCRNL GKTIKKAIPS HHLHLRSLGG SLYRRRIQSS SMETDLKSTF LNVYSVLKSD
     LLHDPSFEFT NESRLWVDRM LDYNVRGGKL NRGLSVVDSF KLLKQGNDLT EQEVFLSCAL
     GWCIEWLQAY FLVLDDIMDN SVTRRGQPCW FRVPQVGMVA INDGILLRNH IHRILKKHFR
     DKPYYVDLVD LFNEVELQTA CGQMIDLITT FEGEKDLAKY SLSIHRRIVQ YKTAYYSFYL
     PVACALLMAG ENLENHIDVK NVLVDMGIYF QVQDDYLDCF ADPETLGKIG TDIEDFKCSW
     LVVKALERCS EEQTKILYEN YGKPDPSNVA KVKDLYKELD LEGVFMEYES KSYEKLTGAI
     EGHQSKAIQA VLKSFLAKIY KRQK
//

If you have problems or comments...

PBIL Back to PBIL home page