(data stored in ACNUC8465 zone)

HOGENOM: ARATH_5_PE6502

ID   ARATH_5_PE6502                       STANDARD;      PRT;   356 AA.
AC   ARATH_5_PE6502; Q9FJV0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Mitogen-activated protein kinase kinase 6; Short=AtMKK6;
DE   Short=MAP kinase kinase 6; EC=2.7.12 2;AltName: Full=Protein Arabidopsis
DE   NQK1 homolog; (ARATH_5.PE6502).
GN   Name=MKK6; Synonyms=ANQ1; OrderedLocusNames=At5g56580;
OS   ARABIDOPSIS THALIANA.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids;
OC   eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ARATH_5.PE6502.
CC       Arabidopsis thaliana chromosome 5 TAIR10 full sequence 1..26975502
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:M2K6_ARATH
CC   -!- FUNCTION: Involved in the regulation of plant cytokinesis during
CC       meiosis and mitosis. Activates MPK13 in vitro.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated through serine and threonine
CC       phosphorylation (By similarity).
CC   -!- INTERACTION:
CC       Q8GYQ5:MPK12; NbExp=2; IntAct=EBI-1238868, EBI-2128461;
CC   -!- TISSUE SPECIFICITY: Expressed in roots, stems and flower buds.
CC   -!- PTM: Phosphorylated on Ser-221 and Thr-227, which activates the
CC       enzyme (By similarity).
CC   -!- DISRUPTION PHENOTYPE: Plants exhibit a dwarf phenotype with fewer
CC       flowers, large cells with multiple nuclei in various organs and
CC       large malformed pollen grains.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Arabidopsis_thaliana;AT5G56580;AT5G56580.1;AT5G56580.1.
DR   EMBL; AB013392; - ;
DR   EMBL; AB104460; - ;
DR   UniProtKB/Swiss-Prot; Q9FJV0; -.
DR   EMBL; AB104460; BAC76067.1; -; mRNA.
DR   EMBL; AB013392; BAB09875.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED96783.1; -; Genomic_DNA.
DR   IPI; IPI00537754; -.
DR   RefSeq; NP_200469.1; NM_125041.2.
DR   UniGene; At.29375; -.
DR   ProteinModelPortal; Q9FJV0; -.
DR   SMR; Q9FJV0; 64-344.
DR   IntAct; Q9FJV0; 5.
DR   MINT; MINT-1206105; -.
DR   STRING; Q9FJV0; -.
DR   PRIDE; Q9FJV0; -.
DR   EnsemblPlants; AT5G56580.1; AT5G56580.1; AT5G56580.
DR   GeneID; 835759; -.
DR   GenomeReviews; BA000015_GR; AT5G56580.
DR   KEGG; ath:AT5G56580; -.
DR   NMPDR; fig|3702.1.peg.27598; -.
DR   GeneFarm; 876; 89.
DR   TAIR; At5g56580; -.
DR   eggNOG; KOG0581; -.
DR   GeneTree; EPGT00070000031255; -.
DR   InParanoid; Q9FJV0; -.
DR   OMA; FIKKFED; -.
DR   PhylomeDB; Q9FJV0; -.
DR   ProtClustDB; CLSN2685391; -.
DR   Genevestigator; Q9FJV0; -.
DR   GermOnline; AT5G56580; Arabidopsis thaliana.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004708; F:MAP kinase kinase activity; IDA:TAIR.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; ARATH_5.PE6502; -.
KW   AT5G56580pg.C_scaffold_1320000031; AT5G56580.10C_scaffold_1320000031;
KW   AB013392; AB104460;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide-binding;
KW   Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase.
SQ   SEQUENCE   356 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MVKIKSNLKQ LKLSVPAQES PISSFLTASG TFHDGDFLLN QKGLRLTSDE KQSRQSDSKE
     LDFEITAEDL ETVKVIGKGS GGVVQLVRHK WVGKFFAMKV IQMNIQEEIR KQIVQELKIN
     QASSQCPHVV VCYHSFYHNG AFSLVLEYMD RGSLADVIRQ VKTILEPYLA VVCKQVLLGL
     VYLHNERHVI HRDIKPSNLL VNHKGEVKIS DFGVSASLAS SMGQRDTFVG TYNYMSPERI
     SGSTYDYSSD IWSLGMSVLE CAIGRFPYLE SEDQQNPPSF YELLAAIVEN PPPTAPSDQF
     SPEFCSFVSA CIQKDPPARA SSLDLLSHPF IKKFEDKDID LGILVGTLEP PVNYLR
//

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