(data stored in ACNUC6163 zone)

HOVERGEN: AT8A2_MOUSE

ID   AT8A2_MOUSE             Reviewed;        1148 AA.
AC   P98200; B2RQF2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-NOV-2009, entry version 73.
DE   RecName: Full=Probable phospholipid-transporting ATPase IB;
DE            EC=3.6.3.1;
DE   AltName: Full=ATPase class I type 8A member 2;
GN   Name=Atp8a2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ICR;
RX   MEDLINE=20473714; PubMed=11015572;
RA   Halleck M.S., Lawler J.F. Jr., Blackshaw S., Gao L., Nagarajan P.,
RA   Hacker C., Pyle S., Newman J.T., Nakanishi Y., Ando H., Weinstock D.,
RA   Williamson P.L., Schlegel R.A.;
RT   "Differential expression of putative transbilayer amphipath
RT   transporters.";
RL   Physiol. Genomics 1:139-150(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-5, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Brain cortex;
RX   PubMed=17114649; DOI=10.1074/mcp.M600046-MCP200;
RA   Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,
RA   Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,
RA   Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
RT   "Qualitative and quantitative analyses of protein phosphorylation in
RT   naive and stimulated mouse synaptosomal preparations.";
RL   Mol. Cell. Proteomics 6:283-293(2007).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP +
CC       phosphate + phospholipid(Out).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Found in testis, heart and brain. Most
CC       abundant in testis. Also detected in fetal tissues.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type)
CC       family. Type IV subfamily.
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CC   -!- GENE_FAMILY: HBG050601 [ FAMILY / ALN / TREE ]
DR   EMBL; AF156550; AAF09448.1; -; mRNA.
DR   EMBL; BC137896; AAI37897.1; -; mRNA.
DR   IPI; IPI00127464; -.
DR   RefSeq; NP_056618.1; -.
DR   UniGene; Mm.319599; -.
DR   STRING; P98200; -.
DR   PRIDE; P98200; -.
DR   Ensembl; ENSMUST00000080368; ENSMUSP00000079238; ENSMUSG00000021983; Mus musculus.
DR   GeneID; 50769; -.
DR   KEGG; mmu:50769; -.
DR   UCSC; uc007uet.1; mouse.
DR   CTD; 50769; -.
DR   MGI; MGI:1354710; Atp8a2.
DR   HOGENOM; P98200; -.
DR   HOVERGEN; P98200; -.
DR   OMA; MKGQATM; -.
DR   BRENDA; 3.6.3.1; 244.
DR   NextBio; 307683; -.
DR   ArrayExpress; P98200; -.
DR   Bgee; P98200; -.
DR   Genevestigator; P98200; -.
DR   GermOnline; ENSMUSG00000021983; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015662; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004012; F:phospholipid-translocating ATPase activity; IEA:EC.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
DR   GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR   InterPro; IPR008250; ATPase_P-typ_ATPase-assoc-reg.
DR   InterPro; IPR001757; ATPase_P-typ_ion-transptr.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR006539; ATPase_P-typ_Plipid-transl.
DR   PANTHER; PTHR11939; ATPase_P; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   TIGRFAMs; TIGR01652; ATPase-Plipid; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 3.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P98200.
DR   SWISS-2DPAGE; P98200.
KW   ATP-binding; Hydrolase; Magnesium; Membrane; Metal-binding;
KW   Nucleotide-binding; Phosphoprotein; Transmembrane.
FT   DOMAIN       30     61       PRODOM:2005.1:PD584476  133
FT   DOMAIN       73    150       PRODOM:2005.1:PD583714  159
FT   DOMAIN      152    201       PRODOM:2005.1:PD111436  109
FT   DOMAIN      204    255       PRODOM:2005.1:PD004982  138
FT   DOMAIN      256    338       PRODOM:2005.1:PD006317  109
FT   DOMAIN      340    370       PRODOM:2005.1:PD876157  42
FT   DOMAIN      373    411       PRODOM:2005.1:PD864285  143
FT   DOMAIN      412    454       PRODOM:2005.1:PDA1F608  4
FT   DOMAIN      455    516       PRODOM:2005.1:PD003346  121
FT   DOMAIN      536    577       PRODOM:2005.1:PD461286  88
FT   DOMAIN      580    628       PRODOM:2005.1:PD250570  129
FT   DOMAIN      630    661       PRODOM:2005.1:PD336512  128
FT   DOMAIN      662    697       PRODOM:2005.1:PD030421  130
FT   DOMAIN      703    755       PRODOM:2005.1:PD004657  92
FT   DOMAIN      775    812       PRODOM:2005.1:PD005736  137
FT   DOMAIN      814    856       PRODOM:2005.1:PD435496  137
FT   DOMAIN      857    922       PRODOM:2005.1:PD304524  143
FT   DOMAIN      961   1010       PRODOM:2005.1:PDA1E1E9  67
FT   DOMAIN     1012   1082       PRODOM:2005.1:PD038238  8
FT   DOMAIN     1089   1142       PRODOM:2005.1:PD689570  11
FT   CHAIN         1   1148       Probable phospholipid-transporting ATPase
FT                                IB.
FT                                /FTId=PRO_0000046363.
FT   TOPO_DOM      1     44       Cytoplasmic (Potential).
FT   TRANSMEM     45     66       Potential.
FT   TOPO_DOM     67     71       Extracellular (Potential).
FT   TRANSMEM     72     94       Potential.
FT   TOPO_DOM     95    276       Cytoplasmic (Potential).
FT   TRANSMEM    277    298       Potential.
FT   TOPO_DOM    299    323       Extracellular (Potential).
FT   TRANSMEM    324    345       Potential.
FT   TOPO_DOM    346    837       Cytoplasmic (Potential).
FT   TRANSMEM    838    858       Potential.
FT   TOPO_DOM    859    870       Extracellular (Potential).
FT   TRANSMEM    871    890       Potential.
FT   TOPO_DOM    891    920       Cytoplasmic (Potential).
FT   TRANSMEM    921    942       Potential.
FT   TOPO_DOM    943    956       Extracellular (Potential).
FT   TRANSMEM    957    979       Potential.
FT   TOPO_DOM    980    985       Cytoplasmic (Potential).
FT   TRANSMEM    986   1006       Potential.
FT   TOPO_DOM   1007   1024       Extracellular (Potential).
FT   TRANSMEM   1025   1049       Potential.
FT   TOPO_DOM   1050   1148       Cytoplasmic (Potential).
FT   ACT_SITE    388    388       4-aspartylphosphate intermediate (By
FT                                similarity).
FT   METAL       781    781       Magnesium (By similarity).
FT   METAL       785    785       Magnesium (By similarity).
FT   MOD_RES       5      5       Phosphothreonine.
SQ   SEQUENCE   1148 AA;  129417 MW;  A668D6F343CAAAB8 CRC64;
     MSRATSVGDQ LEAPARIIYL NQSHLNKFCD NRISTAKYSV LTFLPRFLYE QIRRAANAFF
     LFIALLQQIP DVSPTGRYTT LVPLVIILTI AGIKEIIEDF KRHKADNAVN KKKTIVLRNG
     MWHTIMWKEV AVGDIVKVLN GQYLPADMVL FSSSEPQGMC YVETANLDGE TNLKIRQGLS
     HTTDMQTRDV LMKLSGRIEC EGPNRHLYDF TGNLHLDGKS SVALGPDQIL LRGTQLRNTQ
     WVFGVVVYTG HDSKLMQNST KAPLKRSNVE KVTNVQILVL FGILLVMALV SSVGALFWNG
     SHGGKSWYIK KMDTNSDNFG YNLLTFIILY NNLIPISLLV TLEVVKYTQA LFINWDMDMY
     YIENDTPAMA RTSNLNEELG QVKYLFSDKT GTLTCNIMNF KKCSIAGVTY GHFPELAREQ
     SSDDFCRMTS CTNDSCDFND PRLLKNIEDQ HPTAPCIQEF LTLLAVCHTV VPEKDGDEII
     YQASSPDEAA LVKGAKKLGF VFTGRTPYSV IIEAMGQEQT FGILNVLEFS SDRKRMSVIV
     RLPSGQLRLY CKGADNVIFE RLSKDSKYME ETLCHLEYFA TEGLRTLCVA YADLSENEYE
     EWLKVYQEAS IILKDRAQRL EECYEIIEKN LLLLGATAIE DRLQAGVPET IATLLKAEIK
     IWVLTGDKQE TAINIGYSCR LVSQNMALIL LKEDSLDATR AAITQHCTDL GNLLGKENDV
     ALIIDGHTLK YALSFEVRRS FLDLALSCKA VICCRVSPLQ KSEIVDVVKK RVKAITLAIG
     DGANDVGMIQ TAHVGVGISG NEGMQATNNS DYAIAQFSYL EKLLLVHGAW SYNRVTKCIL
     YCFYKNVVLY IIELWFAFVN GFSGQILFER WCIGLYNVIF TALPPFTLGI FERSCTQESM
     LRFPQLYRIT QNAEGFNTKV FWGHCINALV HSLILFWVPM KALEHDTPVT SGHATDYLFV
     GNIVYTYVVV TVCLKAGLET TAWTKFSHLA VWGSMLIWLV FFGVYSTIWP TIPIAPDMKG
     QATMVLSSAY FWLGLFLVPT ACLIEDVAWR AAKHTCKKTL LEEVQELETK SRVMGKAMLR
     DSNGKRMNER DRLIKRLSRK TPPTLFRTGS IQQCVSHGYA FSQEEHGAVT QEEIVRAYDT
     TKENSRKK
//

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