(data stored in ACNUC4932 zone)

HOVERGEN: B0FLL2_HUMAN

ID   B0FLL2_HUMAN            Unreviewed;       472 AA.
AC   B0FLL2;
DT   26-FEB-2008, integrated into UniProtKB/TrEMBL.
DT   26-FEB-2008, sequence version 1.
DT   03-NOV-2009, entry version 14.
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 2 transcript variant 3;
DE            EC=3.1.3.46;
GN   Name=PFKFB2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16025159;
RA   Minchenko O.H., Opentanova I.L., Ogura T., Minchenko D.O.,
RA   Komisarenko S.V., Caro J., Esumi H.;
RT   "Expression and hypoxia-responsiveness of 6-phosphofructo-2-
RT   kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell
RT   lines.";
RL   Acta Biochim. Pol. 52:881-888(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15925437; DOI=10.1016/j.biochi.2005.04.007;
RA   Minchenko O.H., Ochiai A., Opentanova I.L., Ogura T., Minchenko D.O.,
RA   Caro J., Komisarenko S.V., Esumi H.;
RT   "Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-
RT   bisphosphatase-4 in the human breast and colon malignant tumors.";
RL   Biochimie 87:1005-1010(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RA   Minchenko D.O., Moenner M., Minchenko O.H., Tsuchihara K.,
RA   Kanehara S., Bikfalvi A., Esumi H.;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; EU334168; ABY59650.1; -; mRNA.
DR   IPI; IPI00305589; -.
DR   UniGene; Hs.282702; -.
DR   STRING; B0FLL2; -.
DR   Ensembl; ENST00000367079; ENSP00000356046; ENSG00000123836; Homo sapiens.
DR   Ensembl; ENST00000367080; ENSP00000356047; ENSG00000123836; Homo sapiens.
DR   Ensembl; ENST00000411990; ENSP00000408717; ENSG00000123836; Homo sapiens.
DR   UCSC; uc009xcc.1; human.
DR   HGNC; HGNC:8873; PFKFB2.
DR   Bgee; B0FLL2; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase act...; IEA:EC.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; B0FLL2.
DR   SWISS-2DPAGE; B0FLL2.
KW   Hydrolase; Kinase.
SQ   SEQUENCE   472 AA;  54778 MW;  964B10D75E28B871 CRC64;
     MTNSPTLIVM IGLPARGKTY VSKKLTRYLN WIGVPTKVFN LGVYRREAVK SYKSYDFFRH
     DNEEAMKIRK QCALVALEDV KAYLTEENGQ IAVFDATNTT RERRDMILNF AEQNSFKVFF
     VESVCDDPDV IAANILEVKV SSPDYPERNR ENVMEDFLKR IECYKVTYRP LDPDNYDKDL
     SFIKVINVGQ RFLVNRVQDY IQSKIVYYLM NIHVQPRTIY LCRHGESEFN LLGKIGGDSG
     LSVRGKQFAQ ALRKFLEEQE ITDLKVWTSQ LKRTIQTAES LGVPYEQWKI LNEIDAGVCE
     EMTYAEIEKR YPEEFALRDQ EKYLYRYPGG ESYQDLVQRL EPVIMELERQ GNVLVISHQA
     VMRCLLAYFL DKGADELPYL RCPLHTIFKL TPVAYGCKVE TIKLNVEAVN THRDKPTNNF
     PKNQTPVRMR RNSFTPLSSS NTIRRPRNYS VGSRPLKPLS PLRAQDMQEG AD
//

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