(data stored in ACNUC13530 zone)

HOVERGEN: B4DHN0_HUMAN

ID   B4DHN0_HUMAN            Unreviewed;       348 AA.
AC   B4DHN0;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   03-NOV-2009, entry version 12.
DE   SubName: Full=cDNA FLJ58314, highly similar to Mitogen-activated protein kinase 1 (EC 2.7.11.24);
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
CC   -!- GENE_FAMILY: HBG014652 [ FAMILY / ALN / TREE ]
DR   EMBL; AK295188; BAG58192.1; -; mRNA.
DR   IPI; IPI00003479; -.
DR   UniGene; Hs.431850; -.
DR   STRING; B4DHN0; -.
DR   Ensembl; ENST00000215832; ENSP00000215832; ENSG00000100030; Homo sapiens.
DR   Ensembl; ENST00000398822; ENSP00000381803; ENSG00000100030; Homo sapiens.
DR   Ensembl; ENST00000415911; ENSP00000409149; ENSG00000100030; Homo sapiens.
DR   HGNC; HGNC:6871; MAPK1.
DR   Bgee; B4DHN0; -.
DR   GO; GO:0005829; C:cytosol; IEA:Compara.
DR   GO; GO:0005634; C:nucleus; IEA:Compara.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016908; F:MAP kinase 2 activity; IEA:Compara.
DR   GO; GO:0001784; F:phosphotyrosine binding; IEA:Compara.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
DR   GO; GO:0019858; P:cytosine metabolic process; IEA:Compara.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
DR   GO; GO:0000165; P:MAPKKK cascade; IEA:Compara.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Compara.
DR   GO; GO:0009887; P:organ morphogenesis; IEA:Compara.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:Compara.
DR   GO; GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Compara.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Compara.
DR   InterPro; IPR008349; Erk_1_2_MAPK.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003527; MAP_kinase_CS.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_prot_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_prot_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR01770; ERK1ERK2MAPK.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS01351; MAPK; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; B4DHN0.
DR   SWISS-2DPAGE; B4DHN0.
KW   ATP-binding; Kinase; Nucleotide-binding;
KW   Serine/threonine-protein kinase.
SQ   SEQUENCE   348 AA;  40421 MW;  076BA10FAE3AE8E0 CRC64;
     MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNVNKVRVA IKKISPFEHQ TYCQRTLREI
     KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS NDHICYFLYQ
     ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG FLTEYVATRW
     YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG ILGSPSQEDL
     NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI EVEQALAHPY
     LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS
//

If you have problems or comments...

PBIL Back to PBIL home page