(data stored in ACNUC7421 zone)

HOGENOM: BACIE_1_PE1009

ID   BACIE_1_PE1009                       STANDARD;      PRT;   216 AA.
AC   BACIE_1_PE1009; D6Y0H0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Thiamine-phosphate pyrophosphorylase; Short=TMP
DE   pyrophosphorylase; Short=TMP-PPase; EC=2.5.1 3;AltName:
DE   Full=Thiamine-phosphate synthase; (BACIE_1.PE1009).
GN   Name=thiE; OrderedLocusNames=Bsel_1042;
OS   BACILLUS SELENITIREDUCENS MLS10.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=439292;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BACIE_1.PE1009.
CC       Bacillus selenitireducens MLS10 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:D6Y0H0_BACIE
CC   -!- FUNCTION: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole
CC       monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl
CC       pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate
CC       (TMP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2-methyl-4-amino-5-hydroxymethylpyrimidine
CC       diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)thiazole =
CC       diphosphate + thiamine phosphate.
CC   -!- COFACTOR: Binds 1 magnesium ion per subunit (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis;
CC       thiamine phosphate from 4-amino-2-methyl-5-
CC       diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-
CC       thiazole: step 1/1.
CC   -!- SIMILARITY: Belongs to the TMP-PPase family.
CC   -!- GENE_FAMILY: HOG000155781 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D6Y0H0; -.
DR   EMBL; CP001791; ADH98561.1; -; Genomic_DNA.
DR   RefSeq; YP_003699127.1; NC_014219.1.
DR   ProteinModelPortal; D6Y0H0; -.
DR   GeneID; 9263594; -.
DR   GenomeReviews; CP001791_GR; Bsel_1042.
DR   KEGG; bse:Bsel_1042; -.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:HAMAP.
DR   GO; GO:0004789; F:thiamine-phosphate diphosphorylase activity; IEA:HAMAP.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00097; TMP_PPase; 1; -.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR022998; ThiaminP_synth_SF.
DR   InterPro; IPR003733; TMP_synthase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF02581; TMP-TENI; 1.
DR   SUPFAM; SSF51391; TMP_synthase; 1.
DR   TIGRFAMs; TIGR00693; ThiE; 1.
DR   HOGENOMDNA; BACIE_1.PE1009; -.
KW   Complete proteome; Magnesium; Metal-binding; Thiamine biosynthesis;
KW   Transferase.
SQ   SEQUENCE   216 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKTINDILKV YFIAGTTDAR HMPLPDCLER AIEGGITCFQ YREKGPGALT GDEKTKMGRT
     LRDICQKRGI PFVVNDDVAL AVALEADGIH VGQEDMNASD VKSRIPDGCF LGVSVHSFKE
     AEAAKDAGAD YFGIGPVYPT GSKADAKDAI GPAGIRIYRD AGIKMPVVAI GGITPENTPG
     IMKAGADGVS MISAIAGQED PKAAARAFQH ATTVRT
//

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