(data stored in SCRATCH3701 zone)

HOGENOM6: BACMD_1_PE6

ID   BACMD_1_PE6                          STANDARD;      PRT;   836 AA.
AC   BACMD_1_PE6; D5D922;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (BACMD_1.PE6).
GN   Name=gyrA; OrderedLocusNames=BMD_0006;
OS   BACILLUS MEGATERIUM DSM 319.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=592022;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BACMD_1.PE6.
CC       Bacillus megaterium DSM 319 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:D5D922_BACMD
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D5D922; -.
DR   EMBL; CP001982; ADF36973.1; -; Genomic_DNA.
DR   RefSeq; YP_003595323.1; NC_014103.1.
DR   EnsemblBacteria; EBBACT00000420841; EBBACP00000415513; EBBACG00000422233.
DR   GeneID; 9115397; -.
DR   GenomeReviews; CP001982_GR; BMD_0006.
DR   KEGG; bmd:BMD_0006; -.
DR   GeneTree; EBGT00050000002933; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; BACMD_1.PE6; -.
DR   PRODOM; BACMD_1_PE6.
DR   SWISS-2DPAGE; BACMD_1_PE6.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   836 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDKPNSQIR EVNISQEMRA SFLDYAMSVI VSRALPDVRD GLKPVHRRIL YAMNDLGMGS
     DKPYKKSARI VGEVIGKYHP HGDSAVYETM VRMAQDFSYR YMLIDGHGNF GSVDGDAAAA
     MRYTEARMSK VSMELLRDIN KDTIDYQDNY DGSEREPIVL PARFPNLLVN GSAGIAVGMA
     TNIPPHQLGE VIDGVLAVSQ DPDITIAELM EIIPGPDFPT AGQILGRSGI RKAYETGKGS
     IIVRAKVEIE EQSNGKQTII VHELPYQVNK AKLIEKIAEL ARDKKIDGIT DLRDESDRSG
     MRIVIEVRRD ANANVLLNNL YKQTSLQTSF GINTLALVDG QPKVLNLKQC LQYYLDHQVV
     VIRRRTEFEL RKAEARAHIL EGLKIALDNL DAVIALIRGS QTTDIAREGL MTQFSLSEKQ
     AQAILDMRLQ RLTGLEREKI EAEYQSLLAL IAELKAILAD EEKVLEIIRE ELIEVKERFN
     DGRRTEIVSG GAEIIEDEDL IPRQDIVISL THNGYIKRLP VSTYKSQRRG GRGIQGMNTN
     EDDFVEHLLT TSTHDTILFF TNKGKVYRTK GYEIPEYGRT AKGIPIINLL EVDKGEWVNA
     IIRVDEFVDD WYLFFTTKQG ISKRTPLSSF ENIRNSGLIA LNLREEDELI SVKLTDGKRD
     MVIGTKKGML IRFNENDVRS MGRTATGVKG ITLDSEDEVI GMEILEEQSD VLIITKNGYG
     KRTPIEEYRV QTRGGKGLRT CNITDKNGDV VALKCVSQEE DIMLITVSGV LIRVSVSDIS
     QMGRNTQGVK VIRLGDEEFV STVAKVQTSE DEDEVLDELD EHEETDIIVE AEETEE
//

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