(data stored in ACNUC17686 zone)

HOGENOM: BASUB1_1_PE3152

ID   BASUB1_1_PE3152                      STANDARD;      PRT;   192 AA.
AC   BASUB1_1_PE3152; O32074;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Thiamine transporter ThiT;AltName: Full=Thiamine ECF
DE   transporter S component ThiT; (BASUB1_1.PE3152).
GN   Name=thiT; Synonyms=yuaJ; OrderedLocusNames=BSU30990;
OS   BACILLUS SUBTILIS SUBSP. SUBTILIS STR. 168.
OC   Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BASUB1_1.PE3152.
CC       Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:THIT_BACSU
CC   -!- FUNCTION: Probably a thiamine-binding protein that interacts with
CC       the energy-coupling factor (ECF) ABC-transporter complex. Unlike
CC       classic ABC transporters this ECF transporter provides the energy
CC       necessary to transport a number of different substrates. The
CC       substrates themselves are bound by transmembrane, not
CC       extracytoplasmic soluble proteins (By similarity).
CC   -!- SUBUNIT: Forms a stable energy-coupling factor (ECF) transporter
CC       complex composed of a membrane-embedded substrate-binding protein
CC       (S component), two ATP-binding proteins (A components) and a
CC       transmembrane protein (T component) (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- DISRUPTION PHENOTYPE: Cells display deregulation of thiamine
CC       biosynthesis and impaired export of thiamine products from the
CC       cell.
CC   -!- SIMILARITY: Belongs to the ECF family. Thiamine transporter
CC       (TC 2.A.88) subfamily.
CC   -!- GENE_FAMILY: HOG000013022 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O32074; -.
DR   EMBL; AL009126; CAB15077.1; -; Genomic_DNA.
DR   PIR; C70006; C70006.
DR   RefSeq; NP_390977.1; NC_000964.3.
DR   ProteinModelPortal; O32074; -.
DR   TCDB; 2.A.88.3.1; vitamin uptake transporter (VUT or ECF) family.
DR   EnsemblBacteria; EBBACT00000003186; EBBACP00000003186; EBBACG00000003179.
DR   GeneID; 937137; -.
DR   GenomeReviews; AL009126_GR; BSU30990.
DR   KEGG; bsu:BSU30990; -.
DR   NMPDR; fig|224308.1.peg.3102; -.
DR   GenoList; BSU30990; -.
DR   GeneTree; EBGT00050000002029; -.
DR   OMA; TPVWIYS; -.
DR   ProtClustDB; CLSK887773; -.
DR   BioCyc; BSUB:BSU30990-MON; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR012651; Thia_Transptr_ThiT/YuaJ.
DR   Pfam; PF09515; Thia_YuaJ; 1.
DR   TIGRFAMs; TIGR02357; Thia_yuaJ; 1.
DR   HOGENOMDNA; BASUB1_1.PE3152; -.
KW   thiamin permease;
KW   Cell membrane; Complete proteome; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   192 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNQSKQLVRL IEIAIMTAAA VILDIVSGMF LSMPQGGSVS IMMIPIFLIS FRWGVKAGLT
     TGLLTGLVQI AIGNLFAQHP VQLLLDYIVA FAAIGISGCF ASSVRKAAVS KTKGKLIVSV
     VSAVFIGSLL RYAAHVISGA VFFGSFAPKG TPVWIYSLTY NATYMVPSFI ICAIVLCLLF
     MTAPRLLKSD KA
//

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