(data stored in ACNUC7421 zone)

HOGENOM: BIFDB_1_PE1015

ID   BIFDB_1_PE1015                       STANDARD;      PRT;   636 AA.
AC   BIFDB_1_PE1015; D2QA78;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Elongation factor 4; Short=EF-4; EC=3.6.5 n1;AltName:
DE   Full=Ribosomal back-translocase LepA; (BIFDB_1.PE1015).
GN   Name=lepA; OrderedLocusNames=BDP_1076;
OS   BIFIDOBACTERIUM DENTIUM BD1.
OC   Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=401473;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BIFDB_1.PE1015.
CC       Bifidobacterium dentium Bd1 chromosome, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:D2QA78_BIFDB
CC   -!- FUNCTION: Required for accurate and efficient protein synthesis
CC       under certain stress conditions. May act as a fidelity factor of
CC       the translation reaction, by catalyzing a one-codon backward
CC       translocation of tRNAs on improperly translocated ribosomes. Back-
CC       translocation proceeds from a post-translocation (POST) complex to
CC       a pre-translocation (PRE) complex, thus giving elongation factor G
CC       a second chance to translocate the tRNAs correctly. Binds to
CC       ribosomes in a GTP-dependent manner (By similarity).
CC   -!- CATALYTIC ACTIVITY: GTP + H(2)O = GDP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side (By similarity).
CC   -!- SIMILARITY: Belongs to the GTP-binding elongation factor family.
CC       LepA subfamily.
CC   -!- GENE_FAMILY: HOG000020624 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D2QA78; -.
DR   EMBL; CP001750; ADB09714.1; -; Genomic_DNA.
DR   RefSeq; YP_003360538.1; NC_013714.1.
DR   ProteinModelPortal; D2QA78; -.
DR   GeneID; 8691881; -.
DR   GenomeReviews; CP001750_GR; BDP_1076.
DR   KEGG; bde:BDP_1076; -.
DR   OMA; KCYGGDA; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:HAMAP.
DR   GO; GO:0003924; F:GTPase activity; IEA:HAMAP.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0043022; F:ribosome binding; IEA:HAMAP.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:HAMAP.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:HAMAP.
DR   HAMAP; MF_00071; LepA; 1; -.
DR   InterPro; IPR009022; Elongation_fac_G/III/V.
DR   InterPro; IPR006297; LepA_GTP-bd.
DR   InterPro; IPR013842; LepA_GTP-bd_C.
DR   InterPro; IPR000795; ProtSyn_GTP-bd.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000640; Transl_elong_EFG/EF2_C.
DR   InterPro; IPR004161; Transl_elong_EFTu/EF1A_2.
DR   InterPro; IPR009000; Transl_elong_init/rib_B-barrel.
DR   Gene3D; G3DSA:3.30.70.240; Transl_elong_EFG/EF2_C; 1.
DR   Pfam; PF00679; EFG_C; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF06421; LepA_C; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SMART; SM00838; EFG_C; 1.
DR   SUPFAM; SSF54980; EFG_III_V; 2.
DR   SUPFAM; SSF50447; Translat_factor; 1.
DR   TIGRFAMs; TIGR01393; LepA; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS00301; EFACTOR_GTP; 1.
DR   HOGENOMDNA; BIFDB_1.PE1015; -.
KW   GTP-binding protein LepA;
KW   Cell membrane; Complete proteome; GTP-binding; Hydrolase; Membrane;
KW   Nucleotide-binding; Nucleotidyltransferase; Protein biosynthesis;
KW   Transferase.
SQ   SEQUENCE   636 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRYVFQEEDG VGQQHNQPGF TDQSLIRNFC IIAHIDHGKS TVADRILQLS GIVPEREMRD
     RFLDRMDIEQ ERGITIKSQA VRVPWTFDGT EYTLGMIDTP GHVDFTYEVS RALAACEGAV
     LLVDATQGIE AQTLSNLYMA IDHDLAIIPV LNKIDLPSAE PDKHAEEIAG LIGCDSSDVL
     RVSGKTGEGV AELLDRIVTD IPAPKGEPDA PARALIFDSV YDSYRGIVTY IRMVDGELRS
     REKLHMMGIG MTHDPIEIGV ISPDMMPTKA LGAGEVGYVI TGAKDVSQSK VGDTITSAAN
     PATEPLEGYR DPQPMVYAGL FPIDNAQFPE LREALDKLKL NDAALIYEPE TSVALGFGFR
     CGFLGLLHME IVTERLSREF NLDLISTAPN VPYEVTAEDG SVHRVTNPSE FPDGKIKRIV
     EPMVAADIIT PKDFIGAVMD LCQDHRGQMG TMEYISSDRV EMHYRIPLAE IVFDFFDQLK
     SRTKGYASLD YHEDGEQAAD LVKVDILIQG EKVDAFSAIV HRDKAYSYGV MMTKKLRELI
     PRQQFEIPIQ AAIGSRIIAR ENIRALRKDV LAKCYGGDIS RKRKLLEKQK AGKKRMKMLG
     HVEVPQEAFI AALSTGDAGN DRDTKDKIRA AQKTEG
//

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