(data stored in ACNUC9552 zone)

HOGENOM: BOVIN10_23_PE44

ID   BOVIN10_23_PE44                      STANDARD;      PRT;   193 AA.
AC   BOVIN10_23_PE44; Q1RMX3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bcl-2-like protein 2; Short=Bcl2-L-2;AltName:
DE   Full=Apoptosis regulator Bcl-W; (BOVIN10_23.PE44).
GN   Name=BCL2L2;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN10_23.PE44.
CC       Bos taurus chromosome 10 Btau_4.0 partial sequence 21239980..22239979
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:B2CL2_BOVIN
CC   -!- FUNCTION: Promotes cell survival. Blocks dexamethasone-induced
CC       apoptosis. Mediates survival of postmitotic Sertoli cells by
CC       suppressing death-promoting activity of BAX (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane; Peripheral membrane
CC       protein (By similarity). Note=Loosely associated with the
CC       mitochondrial membrane in healthy cells. During apoptosis, tightly
CC       bound to the membrane (By similarity).
CC   -!- DOMAIN: The BH4 motif seems to be involved in the anti-apoptotic
CC       function (By similarity).
CC   -!- DOMAIN: The BH1 and BH2 motifs form a hydrophobic groove which
CC       acts as a docking site for the BH3 domain of some pro-apoptotic
CC       proteins. The C-terminal residues of BCL2L2 fold into the BH3-
CC       binding cleft and modulate pro-survival activity by regulating
CC       ligand access. When BH3 domain-containing proteins bind, they
CC       displace the C-terminus, allowing its insertion into the membrane
CC       and neutralizing the pro-survival activity of BCL2L2 (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the Bcl-2 family.
CC   -!- GENE_FAMILY: HOG000056452 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000019692;ENSBTAT00000026248;ENSBTAP00000026248.
DR   EMBL; AB238938; - ;
DR   EMBL; BC114652; - ;
DR   EMBL; DQ001758; - ;
DR   UniProtKB/Swiss-Prot; Q1RMX3; -.
DR   EMBL; BC114652; AAI14653.1; -; mRNA.
DR   IPI; IPI00688324; -.
DR   RefSeq; NP_001070001.1; NM_001076533.1.
DR   UniGene; Bt.53488; -.
DR   ProteinModelPortal; Q1RMX3; -.
DR   SMR; Q1RMX3; 1-183.
DR   STRING; Q1RMX3; -.
DR   Ensembl; ENSBTAT00000026248; ENSBTAP00000026248; ENSBTAG00000019692.
DR   GeneID; 767601; -.
DR   KEGG; bta:767601; -.
DR   CTD; 599; -.
DR   InParanoid; Q1RMX3; -.
DR   OMA; RMATPAS; -.
DR   OrthoDB; EOG4RBQKR; -.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0042981; P:regulation of apoptosis; IEA:InterPro.
DR   InterPro; IPR013280; Apop_reg_BclW.
DR   InterPro; IPR002475; Bcl2-like_apoptosis.
DR   InterPro; IPR000712; Bcl2_BH.
DR   InterPro; IPR020717; Bcl2_BH1_motif_CS.
DR   InterPro; IPR020726; Bcl2_BH2_motif_CS.
DR   InterPro; IPR003093; Bcl2_BH4.
DR   InterPro; IPR020731; Bcl2_BH4_motif_CS.
DR   Pfam; PF00452; Bcl-2; 1.
DR   Pfam; PF02180; BH4; 1.
DR   PRINTS; PR01865; APOPREGBCLW.
DR   PRINTS; PR01862; BCL2FAMILY.
DR   SMART; SM00337; BCL; 1.
DR   SMART; SM00265; BH4; 1.
DR   PROSITE; PS50062; BCL2_FAMILY; 1.
DR   PROSITE; PS01080; BH1; 1.
DR   PROSITE; PS01258; BH2; 1.
DR   PROSITE; PS01260; BH4_1; 1.
DR   PROSITE; PS50063; BH4_2; 1.
DR   HOGENOMDNA; BOVIN10_23.PE44; -.
KW   ENSBTAG00000019692fold_1320000031; ENSBTAP00000026248fold_1320000031;
KW   Q05KI8_BOVIN; Q462R4_BOVIN; AB238938; BC114652; DQ001758;
KW   Apoptosis; Complete proteome; Membrane; Mitochondrion; Phosphoprotein;
KW   Reference proteome.
SQ   SEQUENCE   193 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT
     FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG
     QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RTVLTGAVAL
     GALVTVGAFF ASK
//

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