(data stored in ACNUC18858 zone)

HOGENOM: BOVIN10_53_PE4

ID   BOVIN10_53_PE4                       STANDARD;      PRT;   440 AA.
AC   BOVIN10_53_PE4; Q7YQE1; Q7YQF8; Q866Z3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Beta-1,3-galactosyl-O-glycosyl-glycoprotein
DE   beta-1,6-N-acetylglucosaminyltransferase 3; EC=2.4.1.102; EC=2.4.1
DE   150;AltName: Full=C2GnT-mucin type;AltName: Full=Mucus-type core 2
DE   beta-1,6-N-acetylglucosaminyltransferase;AltName: Full=bC2GnT-M;
DE   Short=C2GnT-M; (BOVIN10_53.PE4).
GN   Name=GCNT3;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN10_53.PE4.
CC       Bos taurus chromosome 10 Btau_4.0 partial sequence 50407264..51407263
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:GCNT3_BOVIN
CC   -!- FUNCTION: Glycosyltransferase that can synthesize all known mucin
CC       beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan
CC       branching, 2 important steps in mucin-type biosynthesis. Has also
CC       I-branching enzyme activity by converting linear into branched
CC       poly-N-acetyllactosaminoglycans, leading to introduce the blood
CC       group I antigen during embryonic development (By similarity).
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-
CC       galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-
CC       galactosaminyl-R.
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-
CC       glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type
CC       II membrane protein (By similarity).
CC   -!- TISSUE SPECIFICITY: Primarily expressed in mucus-secreting
CC       tissues.
CC   -!- PTM: N-glycosylated (Probable).
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 14 family.
CC   -!- GENE_FAMILY: HOG000293251 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000009443;ENSBTAT00000012427;ENSBTAP00000012427.
DR   EMBL; AF465338; - ;
DR   EMBL; AY283763; - ;
DR   EMBL; AY283764; - ;
DR   EMBL; AY283765; - ;
DR   EMBL; AY283766; - ;
DR   EMBL; AY283767; - ;
DR   UniProtKB/Swiss-Prot; Q7YQE1; Q7YQF8; Q866Z3; -.
DR   EMBL; AF465338; AAO22165.1; -; Genomic_DNA.
DR   EMBL; AY283763; AAP76324.1; -; mRNA.
DR   EMBL; AY283764; AAP76325.1; -; mRNA.
DR   EMBL; AY283765; AAP76326.1; -; mRNA.
DR   EMBL; AY283766; AAP76327.1; -; mRNA.
DR   EMBL; AY283767; AAP76328.1; -; Genomic_DNA.
DR   IPI; IPI00712843; -.
DR   RefSeq; NP_991378.1; NM_205809.1.
DR   UniGene; Bt.51854; -.
DR   ProteinModelPortal; Q7YQE1; -.
DR   SMR; Q7YQE1; 70-435.
DR   STRING; Q7YQE1; -.
DR   CAZy; GT14; Glycosyltransferase Family 14.
DR   PRIDE; Q7YQE1; -.
DR   GeneID; 404167; -.
DR   KEGG; bta:404167; -.
DR   CTD; 9245; -.
DR   eggNOG; maNOG07131; -.
DR   GeneTree; ENSGT00550000074330; -.
DR   InParanoid; Q7YQE1; -.
DR   OrthoDB; EOG4X6C8B; -.
DR   PhylomeDB; Q7YQE1; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003829; F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; IEDR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; IEA:EC.
DR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; IEA:EC.
DR   InterPro; IPR003406; Glyco_trans_14.
DR   Pfam; PF02485; Branch; 1.
DR   HOGENOMDNA; BOVIN10_53.PE4; -.
KW   ENSBTAG00000009443fold_1320000031; ENSBTAP00000012427fold_1320000031;
KW   AF465338; AY283763; AY283764; AY283765; AY283766; AY283767;
KW   Complete proteome; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane;
KW   Reference proteome; Signal-anchor; Transferase; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   440 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MKMTGWKKKL CRGHHLWALG CYMLLAVVAL RLSLRLKCDV DSLDLESRDF QSQRCRDVLY
     KNLKLPAKRS ISCSGITRGD QEAVVQALLD NLEVKKKRLP FTDTYYLNIT RDCEQFKAQR
     KFIQFPLSKE ELDFPIAYSM VVHEKIENFE RLLRAVYAPQ NIYCVHVDVK SPETFKEAVK
     AIISCFPNVF MASKLVPVVY ASWSRVQADL NCMEDLLQSS VPWKYLLNTC GTDFPIKTNA
     EMVLALKMLN GKNSMESEIP SEYKKNRWKY RYEVTDRLYL TSKMKDPPPD NLPMFTGNAY
     FVASRAFVQH VLENPKSQRL IEWVKDTYSP DEHLWATLQR APWMPGSVPY HPKYHISDMT
     AIARLVKWQG HEGDVSMGAP YAPCSGIHQR AICIYGAGDL HWILQNHHLL ANKFDPRVDD
     NVLQCLEEYL RHKAIYGTEL
//

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