(data stored in ACNUC29543 zone)

HOGENOM: BOVIN15_77_PE2

ID   BOVIN15_77_PE2                       STANDARD;      PRT;   286 AA.
AC   BOVIN15_77_PE2; Q32L00;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3;
DE   EC=1.14.11 -;AltName: Full=Alkylated DNA repair protein alkB homolog 3;
DE   (BOVIN15_77.PE2).
GN   Name=ALKBH3; Synonyms=ABH3;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN15_77.PE2.
CC       Bos taurus chromosome 15 Btau_4.0 partial sequence 73831989..74831988
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ALKB3_BOVIN
CC   -!- FUNCTION: Dioxygenase that repairs alkylated DNA containing 1-
CC       methyladenine and 3-methylcytosine by oxidative demethylation. Has
CC       a strong preference for single-stranded DNA. May also act on RNA.
CC       Requires molecular oxygen, alpha-ketoglutarate and iron (By
CC       similarity).
CC   -!- COFACTOR: Binds 1 Fe(2+) ion per subunit (By similarity).
CC   -!- ENZYME REGULATION: Activated by ascorbate (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the alkB family.
CC   -!- SIMILARITY: Contains 1 Fe2OG dioxygenase domain.
CC   -!- GENE_FAMILY: HOG000207105 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000009518;ENSBTAT00000012522;ENSBTAP00000012522.
DR   EMBL; BC109832; - ;
DR   UniProtKB/Swiss-Prot; Q32L00; -.
DR   EMBL; BC109832; AAI09833.1; -; mRNA.
DR   IPI; IPI00701660; -.
DR   RefSeq; NP_001032691.1; NM_001037602.1.
DR   UniGene; Bt.52905; -.
DR   ProteinModelPortal; Q32L00; -.
DR   SMR; Q32L00; 70-279.
DR   PRIDE; Q32L00; -.
DR   Ensembl; ENSBTAT00000012522; ENSBTAP00000012522; ENSBTAG00000009518.
DR   GeneID; 514579; -.
DR   KEGG; bta:514579; -.
DR   CTD; 221120; -.
DR   eggNOG; maNOG08946; -.
DR   GeneTree; ENSGT00530000063618; -.
DR   InParanoid; Q32L00; -.
DR   OMA; HWHPVLS; -.
DR   OrthoDB; EOG41JZCZ; -.
DR   PhylomeDB; Q32L00; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043734; F:DNA-N1-methyladenine dioxygenase activity; ISS:UniProtKB.
DR   GO; GO:0008198; F:ferrous iron binding; ISS:UniProtKB.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporDR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0035552; P:oxidative single-stranded DNA demethylation; ISS:UniProtKB.
DR   InterPro; IPR005123; Oxoglutarate/Fe-dep_oxygenase.
DR   Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
DR   HOGENOMDNA; BOVIN15_77.PE2; -.
KW   ENSBTAG00000009518fold_1320000031; ENSBTAP00000012522fold_1320000031;
KW   BC109832;
KW   Complete proteome; Cytoplasm; Dioxygenase; DNA damage; DNA repair;
KW   Iron; Metal-binding; Nucleus; Oxidoreductase; Reference proteome.
SQ   SEQUENCE   286 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEDKRRRARV QGAWAGPAKS QATAQPAPTA ENNLQQRPGK AWMNKEQHLS DRQFVFKEPQ
     EGVRRAPEPR VIEKEGVYEI SMSPTGISRV CLCPGFVDLK EADSVFEQLC RDVPWKQRTG
     IRDDVTYQQP RLTAWYGELP YTYSRITMEP NPHWHPVLLM LKNQIEENTG HSFNSLLCNL
     YRNEKDSVDW HSDDEPSLGR CPIIASLSFG ATRMFEMRKK PPPEDNGDYT YVERVKIPLD
     HGTLLIMEGA TQADWQHRVP KEYHSREPRI NLTFRTVYPD PRGAHW
//

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