(data stored in ACNUC17492 zone)

HOGENOM: BOVIN16_12_PE1

ID   BOVIN16_12_PE1                       STANDARD;      PRT;   221 AA.
AC   BOVIN16_12_PE1; Q0P5H5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Regulator of G-protein signaling 2; Short=RGS2;
DE   (BOVIN16_12.PE1).
GN   Name=RGS2;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN16_12.PE1.
CC       Bos taurus chromosome 16 Btau_4.0 partial sequence 10941749..11941748
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS2_BOVIN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. May play a role in leukemogenesis.
CC       Binds EIF2B5 and blocks its activity, thereby inhibiting the
CC       translation of mRNA into protein (By similarity).
CC   -!- SUBUNIT: Interacts with EIF2B5 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By
CC       similarity). Nucleus, nucleolus (By similarity).
CC   -!- PTM: Phosphorylated by protein kinase C (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000034366;ENSBTAT00000026460;ENSBTAP00000026460.
DR   EMBL; BC120026; - ;
DR   UniProtKB/Swiss-Prot; Q0P5H5; -.
DR   EMBL; BC120026; AAI20027.1; -; mRNA.
DR   IPI; IPI00807247; -.
DR   RefSeq; NP_001069064.1; NM_001075596.1.
DR   RefSeq; XP_002686857.1; XM_002686811.1.
DR   RefSeq; XP_873525.2; XM_868432.4.
DR   UniGene; Bt.10855; -.
DR   ProteinModelPortal; Q0P5H5; -.
DR   SMR; Q0P5H5; 70-203.
DR   STRING; Q0P5H5; -.
DR   GeneID; 513055; -.
DR   GeneID; 616414; -.
DR   KEGG; bta:513055; -.
DR   KEGG; bta:616414; -.
DR   CTD; 5997; -.
DR   eggNOG; maNOG05498; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; Q0P5H5; -.
DR   OrthoDB; EOG4ZGPD8; -.
DR   PhylomeDB; Q0P5H5; -.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; BOVIN16_12.PE1; -.
KW   ENSBTAG00000034366fold_1320000031; ENSBTAP00000026460fold_1320000031;
KW   BC120026;
KW   Cell cycle; Cell membrane; Complete proteome; Cytoplasm; Membrane;
KW   Nucleus; Phosphoprotein; Reference proteome;
KW   Signal transduction inhibitor; Translation regulation.
SQ   SEQUENCE   221 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     QNSILSGREI MQSALFLAVQ HECGPMDKGA GTGPKNEEKR EKMKRTLLKD WKSRLSYFLQ
     NSSSPGKPKT GKKSKQQTFI KPSPEEAQLW SEAFDELLAS KYGLAAFRAF LKSEFCEENI
     EFWLACEDFK KTKSPQKLSS KAKKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF
     TTAQKRVYSL MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
//

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