(data stored in ACNUC17492 zone)

HOGENOM: BOVIN16_62_PE15

ID   BOVIN16_62_PE15                      STANDARD;      PRT;   202 AA.
AC   BOVIN16_62_PE15; O46471; Q08E37;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 16; Short=RGS16;AltName:
DE   Full=Retinal-specific RGS; Short=RGS-r;AltName: Full=Retinally abundant
DE   regulator of G-protein signaling; (BOVIN16_62.PE15).
GN   Name=RGS16;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN16_62.PE15.
CC       Bos taurus chromosome 16 Btau_4.0 partial sequence 60227243..61227242
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS16_BOVIN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha,
CC       but not to G(s)-alpha. May play a role in regulating the kinetics
CC       of signaling in the phototransduction cascade (By similarity).
CC   -!- PTM: Palmitoylated on Cys-2 and/or Cys-12 (By similarity).
CC   -!- PTM: Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced
CC       GTPase accelerating (GAP) activity on G(i)-alpha (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000004305;ENSBTAT00000005642;ENSBTAP00000005642.
DR   EMBL; AF011361; - ;
DR   EMBL; BC123439; - ;
DR   UniProtKB/Swiss-Prot; O46471; Q08E37; -.
DR   EMBL; AF011361; AAC99484.1; -; mRNA.
DR   EMBL; BC123439; AAI23440.1; -; mRNA.
DR   IPI; IPI00711033; -.
DR   RefSeq; NP_776875.1; NM_174450.3.
DR   UniGene; Bt.35906; -.
DR   ProteinModelPortal; O46471; -.
DR   SMR; O46471; 53-188.
DR   STRING; O46471; -.
DR   PRIDE; O46471; -.
DR   Ensembl; ENSBTAT00000005642; ENSBTAP00000005642; ENSBTAG00000004305.
DR   GeneID; 282035; -.
DR   KEGG; bta:282035; -.
DR   CTD; 6004; -.
DR   eggNOG; maNOG04440; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; O46471; -.
DR   OMA; PAEPSHT; -.
DR   OrthoDB; EOG4STS5S; -.
DR   PhylomeDB; O46471; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; ISS:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; BOVIN16_62.PE15; -.
KW   ENSBTAG00000004305fold_1320000031; ENSBTAP00000005642fold_1320000031;
KW   AF011361; BC123439;
KW   Complete proteome; Lipoprotein; Palmitate; Phosphoprotein;
KW   Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   202 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCRTLAAFPT SCLERAKEFK TRLGIFLHKS ELGSDTGSVG KFEWGSKHSK EGKNFSEDVL
     GWKESFDLLL SSKNGVAAFH AFLKTEFSEE NLEFWLACEE FKKLRSATKL GSRAHRIFEE
     FICSEAPKEV NIDHETRELT RTNLQAATAV CFDAAQWKVR ALMEKDSYPR FLKSPAYRDL
     ATQATAASAS PSSSSPAEPL HT
//

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