(data stored in ACNUC29543 zone)

HOGENOM: BOVIN17_68_PE21

ID   BOVIN17_68_PE21                      STANDARD;      PRT;   278 AA.
AC   BOVIN17_68_PE21; Q58DM4; Q0VCG6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2;
DE   EC=1.14.11 -;AltName: Full=Alkylated DNA repair protein alkB homolog 2;
DE   (BOVIN17_68.PE21).
GN   Name=ALKBH2; Synonyms=ABH2;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN17_68.PE21.
CC       Bos taurus chromosome 17 Btau_4.0 partial sequence 66547726..67498487
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ALKB2_BOVIN
CC   -!- FUNCTION: Dioxygenase that repairs alkylated DNA and RNA
CC       containing 1-methyladenine and 3-methylcytosine by oxidative
CC       demethylation. Can also repair alkylated DNA containing 1-
CC       ethenoadenine (in vitro). Has strong preference for double-
CC       stranded DNA. Has low efficiency with single-stranded substrates.
CC       Requires molecular oxygen, alpha-ketoglutarate and iron (By
CC       similarity).
CC   -!- COFACTOR: Binds 1 Fe(2+) ion per subunit (By similarity).
CC   -!- ENZYME REGULATION: Activated by ascorbate and magnesium ions (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Detected in replication foci
CC       during S-phase (By similarity).
CC   -!- SIMILARITY: Belongs to the alkB family.
CC   -!- SIMILARITY: Contains 1 Fe2OG dioxygenase domain.
CC   -!- GENE_FAMILY: HOG000207105 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000019846;ENSBTAT00000026442;ENSBTAP00000026442.
DR   EMBL; BC120178; - ;
DR   EMBL; BT021573; - ;
DR   UniProtKB/Swiss-Prot; Q58DM4; Q0VCG6; -.
DR   EMBL; BT021573; AAX46420.1; -; mRNA.
DR   EMBL; BC120178; AAI20179.1; -; mRNA.
DR   IPI; IPI00704695; -.
DR   RefSeq; NP_001019687.1; NM_001024516.1.
DR   UniGene; Bt.65140; -.
DR   ProteinModelPortal; Q58DM4; -.
DR   SMR; Q58DM4; 55-256.
DR   PRIDE; Q58DM4; -.
DR   GeneID; 511380; -.
DR   KEGG; bta:511380; -.
DR   CTD; 121642; -.
DR   eggNOG; maNOG08708; -.
DR   GeneTree; ENSGT00530000063618; -.
DR   InParanoid; Q58DM4; -.
DR   OrthoDB; EOG4N8R5T; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051747; F:cytosine C-5 DNA demethylase activity; ISS:UniProtKB.
DR   GO; GO:0043734; F:DNA-N1-methyladenine dioxygenase activity; ISS:UniProtKB.
DR   GO; GO:0008198; F:ferrous iron binding; ISS:UniProtKB.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporDR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0035511; P:oxidative DNA demethylation; ISS:UniProtKB.
DR   InterPro; IPR005123; Oxoglutarate/Fe-dep_oxygenase.
DR   Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
DR   HOGENOMDNA; BOVIN17_68.PE21; -.
KW   ENSBTAG00000019846fold_1320000031; ENSBTAP00000026442fold_1320000031;
KW   BC120178; BT021573;
KW   Complete proteome; Dioxygenase; DNA damage; DNA repair; Iron;
KW   Magnesium; Metal-binding; Nucleus; Oxidoreductase; Reference proteome.
SQ   SEQUENCE   278 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDRFLVKGAV GSLKRRMEQE QTGGGPAGLA EEEGNSKKNP RRAAPGNGVD SAGLTWGRIR
     AEGLNCDYTI LFGKAEADEI FQELEKEVEY FTGALARVQV FGKWHSVPRK QATYGDTGLT
     YTFSGLTLSP KPWIPVLERV RDRVSLVTGQ TFNFVLINRY KDGQDHIGEH RDDERELAPG
     SPIASVSFGA CRDFVFRHKD SRGKHPSRRL EVVRLQLAHG SLLMMNHPTN THWYHSLPVR
     KKVLAPRVNL TFRKILPTTK RTTLLTASAS VGSFALHS
//

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