(data stored in ACNUC8465 zone)

HOGENOM: BOVIN19_64_PE3

ID   BOVIN19_64_PE3                       STANDARD;      PRT;   334 AA.
AC   BOVIN19_64_PE3; Q5E9X2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 6;
DE   Short=MAP kinase kinase 6; Short=MAPKK 6; EC=2.7.12 2;AltName:
DE   Full=MAPK/ERK kinase 6; Short=MEK 6; (BOVIN19_64.PE3).
GN   Name=MAP2K6;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN19_64.PE3.
CC       Bos taurus chromosome 19 Btau_4.0 partial sequence 62478724..63478723
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K6_BOVIN
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in MAP kinase p38 exclusively (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Probably activated by dual phosphorylation on
CC       Ser-207 and Thr-211 (By similarity).
CC   -!- PTM: Weakly autophosphorylated. Phosphorylated by TAOK2 (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000001609;ENSBTAT00000002115;ENSBTAP00000002115.
DR   EMBL; BT020798; - ;
DR   EMBL; U76873; - ;
DR   UniProtKB/Swiss-Prot; Q5E9X2; -.
DR   EMBL; BT020798; AAX08815.1; -; mRNA.
DR   IPI; IPI00690263; -.
DR   RefSeq; NP_001029217.1; NM_001034045.1.
DR   UniGene; Bt.561; -.
DR   HSSP; P36507; 1S9I.
DR   ProteinModelPortal; Q5E9X2; -.
DR   STRING; Q5E9X2; -.
DR   PRIDE; Q5E9X2; -.
DR   Ensembl; ENSBTAT00000002115; ENSBTAP00000002115; ENSBTAG00000001609.
DR   GeneID; 286883; -.
DR   KEGG; bta:286883; -.
DR   CTD; 5608; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q5E9X2; -.
DR   OrthoDB; EOG4P2Q2M; -.
DR   PhylomeDB; Q5E9X2; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; BOVIN19_64.PE3; -.
KW   ENSBTAG00000001609fold_1320000031; ENSBTAP00000002115fold_1320000031;
KW   P79118_BOVIN; BT020798; U76873;
KW   Acetylation; ATP-binding; Complete proteome; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   334 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIVELG
     RGAYGVVEKM RHVPSEQIMA VKRIRATVNS QEQKRLLMDL DISMRTVDCP FTVTFYGALF
     REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV
     KPSNVLINAL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI
     WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSEEFVDF TSQCLKKNSK
     ERPTYPELMQ HPFFTLHESK ATDVASFVKS ILGD
//

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