(data stored in ACNUC8465 zone)

HOGENOM: BOVIN22_54_PE20

ID   BOVIN22_54_PE20                      STANDARD;      PRT;   193 AA.
AC   BOVIN22_54_PE20; P61585; P06749; Q3ZC72; Q9UEJ4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Transforming protein RhoA;AltName: Full=Gb;AltName:
DE   Full=p21;Flags: Precursor; (BOVIN22_54.PE20).
GN   Name=RHOA; Synonyms=ARHA, RHO12;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN22_54.PE20.
CC       Bos taurus chromosome 22 Btau_4.0 partial sequence 51151786..52103987
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RHOA_BOVIN
CC   -!- FUNCTION: Regulates a signal transduction pathway linking plasma
CC       membrane receptors to the assembly of focal adhesions and actin
CC       stress fibers. May be an activator of PLCE1. Activated by ARHGEF2,
CC       which promotes the exchange of GDP for GTP. Essential for the
CC       SPATA13-mediated regulation of cell migration and adhesion
CC       assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway
CC       plays an important role in ERBB2-dependent stabilization of
CC       microtubules at the cell cortex. It controls the localization of
CC       APC and CLASP2 to the cell membrane, via the regulation of GSK3B
CC       activity. In turn, membrane-bound APC allows the localization of
CC       the MACF1 to the cell membrane, which is required for microtubule
CC       capture and stabilization (By similarity).
CC   -!- COFACTOR: Magnesium (By similarity).
CC   -!- SUBUNIT: Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF2,
CC       ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13. Interacts
CC       with RGNEF. Interacts with DIAPH1. Interacts (in the
CC       constitutively activated, GTP-bound form) with DGKQ. Interacts
CC       with GNB2L1/RACK1; enhances RHOA activation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side. Cytoplasm, cytoskeleton.
CC   -!- PTM: Substrate for botulinum ADP-ribosyltransferase.
CC   -!- PTM: Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3
CC       ubiquitin ligase complexes, leading to its degradation by the
CC       proteasome, thereby regulating the actin cytoskeleton and cell
CC       migration (By similarity).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
CC   -!- GENE_FAMILY: HOG000233974 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000004279;ENSBTAT00000005600;ENSBTAP00000005600.
DR   EMBL; BC102880; - ;
DR   EMBL; M27278; - ;
DR   UniProtKB/Swiss-Prot; P61585; P06749; Q3ZC72; Q9UEJ4; -.
DR   EMBL; M27278; AAA30409.1; -; mRNA.
DR   EMBL; BC102880; AAI02881.1; -; mRNA.
DR   IPI; IPI00688998; -.
DR   PIR; A33518; TVBO12.
DR   RefSeq; NP_788818.1; NM_176645.3.
DR   UniGene; Bt.49678; -.
DR   ProteinModelPortal; P61585; -.
DR   SMR; P61585; 2-181.
DR   MINT; MINT-139651; -.
DR   STRING; P61585; -.
DR   PRIDE; P61585; -.
DR   Ensembl; ENSBTAT00000005600; ENSBTAP00000005600; ENSBTAG00000004279.
DR   GeneID; 338049; -.
DR   KEGG; bta:338049; -.
DR   CTD; 387; -.
DR   eggNOG; maNOG11311; -.
DR   GeneTree; ENSGT00550000074256; -.
DR   InParanoid; P61585; -.
DR   OMA; DSPDSLX; -.
DR   OrthoDB; EOG4G4GRD; -.
DR   PhylomeDB; P61585; -.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.
DR   GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR003578; Small_GTPase_Rho.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00174; RHO; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51420; RHO; 1.
DR   HOGENOMDNA; BOVIN22_54.PE20; -.
KW   ENSBTAG00000004279fold_1320000031; ENSBTAP00000005600fold_1320000031;
KW   BC102880; M27278;
KW   ADP-ribosylation; Cell membrane; Complete proteome; Cytoplasm;
KW   Cytoskeleton; Direct protein sequencing; GTP-binding; Lipoprotein;
KW   Magnesium; Membrane; Methylation; Nucleotide-binding; Phosphoprotein;
KW   Prenylation; Proto-oncogene; Reference proteome; Ubl conjugation.
SQ   SEQUENCE   193 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT
     AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
     LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ
     ARRGKKKSGC LVL
//

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