(data stored in ACNUC10083 zone)

HOGENOM: BOVIN25_2_PE41

ID   BOVIN25_2_PE41                       STANDARD;      PRT;   811 AA.
AC   BOVIN25_2_PE41; Q4PKH3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=H(+)/Cl(-) exchange transporter 7;AltName: Full=Chloride
DE   channel protein 7; Short=ClC-7; (BOVIN25_2.PE41).
GN   Name=CLCN7;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN25_2.PE41.
CC       Bos taurus chromosome 25 Btau_4.0 partial sequence 1000001..1998503
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN7_BOVIN
CC   -!- FUNCTION: Mediates the exchange of chloride ions against protons.
CC       Functions as antiporter and contributes to the acidification of
CC       the lysosome lumen (By similarity).
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The presence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as antiporters (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-7/CLCN7 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231081 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000015889;ENSBTAT00000021122;ENSBTAP00000021122.
DR   EMBL; BC149961; - ;
DR   EMBL; DQ073465; - ;
DR   UniProtKB/Swiss-Prot; Q4PKH3; -.
DR   EMBL; DQ073465; AAY82470.1; -; mRNA.
DR   IPI; IPI00699745; -.
DR   RefSeq; NP_001020502.1; NM_001025331.1.
DR   UniGene; Bt.6124; -.
DR   ProteinModelPortal; Q4PKH3; -.
DR   PRIDE; Q4PKH3; -.
DR   GeneID; 513545; -.
DR   KEGG; bta:513545; -.
DR   CTD; 1186; -.
DR   eggNOG; maNOG05410; -.
DR   GeneTree; ENSGT00550000074179; -.
DR   InParanoid; Q4PKH3; -.
DR   OrthoDB; EOG41C6VS; -.
DR   PhylomeDB; Q4PKH3; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002249; Cl_channel-7.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01118; CLCHANNEL7.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; BOVIN25_2.PE41; -.
KW   ENSBTAG00000015889fold_1320000031; ENSBTAP00000021122fold_1320000031;
KW   A6QQR2_BOVIN; BC149961; DQ073465;
KW   Antiport; ATP-binding; CBS domain; Chloride; Complete proteome;
KW   Ion transport; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
SQ   SEQUENCE   811 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MANVSKKVSW SGRDLDDDEA APLLRRAPRL GVPAGEAAPL LNGAGPAAAR ASPHSAFFRI
     GQLSSVELDD ELLDPDMDPP HPFPREIPHN EKLLSLKYES LDYDNSENQL FLEEERRINH
     TAFRTVEIKR WVICAMVGIL TGLVACFIDI VVEKLAGLKY RLVKDTADID RFTEHGGLSF
     SLLLWAALNA AFVLLGSTIV AFIEPVAAGS GIPQIKCFLN GVKIPHVVRL KTLVIKVSGV
     ILSVVGGLAV GKEGPMIHSG SVIAAGISQG RSTSLKRDFK IFEYFRRDTE KRDFVSAGAA
     AGVSAAFGAP VGGVLFSLEE GASFWNQFLT WRIFFASMIS TFTLNFVLSI YHGNAWDLSS
     PGLINFGRFD TETMVYVIHE IPIFIAMGVV GGILGAVFNA LNYWLTMFRI RYVHRPCLQV
     VEATLVAAVT ATAAFVLIYS SRDCQPLRGS SVSYPLQLFC ADGEYNSMAV AFFNTPEKSV
     VSLFHDPPGS YNPMTLGLFT LVYFFLACWT YGLTVSAGVF IPSLLIGAAW GRLFGISLSY
     ITGAAVWADP GKYALMGAAA QLGGIVRMTL SLTVIMMEAT SSVTYGFPIM LVLMTAKIVG
     DVFIEGLYDM HIQLQSVPFL HWEAPVTSHS LTAREVMSTP VTCLRRREKV GVIVDVLSST
     ASNHNGFPVV EDADGTQPAR LQGLILRSQL IVLLKHKVFV ERSSMGLLRR RLRLKDFRDA
     YPRFPPIQSI HVSQDERECT MDLSEFMNPS PYTVPQEASL PRVFKLFRAL GLRHLVVVDN
     CNQVVGLVTR KDLARYRLGK GGLEELSLAQ T
//

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