(data stored in ACNUC17492 zone)

HOGENOM: BOVIN26_41_PE13

ID   BOVIN26_41_PE13                      STANDARD;      PRT;   181 AA.
AC   BOVIN26_41_PE13; Q2KHW7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 10; Short=RGS10;
DE   (BOVIN26_41.PE13).
GN   Name=RGS10;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN26_41.PE13.
CC       Bos taurus chromosome 26 Btau_4.0 partial sequence 39247582..40247581
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS10_BOVIN
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Associates specifically with the
CC       activated forms of the G protein subunits G(i)-alpha and G(z)-
CC       alpha but fails to interact with the structurally and functionally
CC       distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited
CC       by palmitoylation of the G-protein (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000002647;ENSBTAT00000003425;ENSBTAP00000003425.
DR   EMBL; BC112856; - ;
DR   UniProtKB/Swiss-Prot; Q2KHW7; -.
DR   EMBL; BC112856; AAI12857.1; -; mRNA.
DR   IPI; IPI00697772; -.
DR   RefSeq; NP_001040005.1; NM_001046540.1.
DR   UniGene; Bt.31630; -.
DR   ProteinModelPortal; Q2KHW7; -.
DR   SMR; Q2KHW7; 33-172.
DR   STRING; Q2KHW7; -.
DR   Ensembl; ENSBTAT00000003425; ENSBTAP00000003425; ENSBTAG00000002647.
DR   GeneID; 614550; -.
DR   KEGG; bta:614550; -.
DR   CTD; 6001; -.
DR   eggNOG; maNOG16565; -.
DR   GeneTree; ENSGT00540000071162; -.
DR   InParanoid; Q2KHW7; -.
DR   OMA; PKSTAKW; -.
DR   OrthoDB; EOG4JM7QV; -.
DR   PhylomeDB; Q2KHW7; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; ISS:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; BOVIN26_41.PE13; -.
KW   ENSBTAG00000002647fold_1320000031; ENSBTAP00000003425fold_1320000031;
KW   BC112856;
KW   Complete proteome; Lipoprotein; Palmitate; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   181 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFNRAVSRLS RKRPPSDIHD SDGSSSSSHQ TPKSTAKWAS SLENLLEDPE GVKRFREFLK
     KEFSEENVLF WLACEDFKKT QDKKQMQEKA KEIYMTFLSS KASSQVNVEG QSRLNEKILE
     EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD LFLKHKRTEE EDEESPDAQT AAKRASRIYN
     T
//

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