(data stored in ACNUC27670 zone)

HOGENOM: BOVIN3_19_PE21

ID   BOVIN3_19_PE21                       STANDARD;      PRT;   94 AA.
AC   BOVIN3_19_PE21; P02639; A5PJ73;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A1;AltName: Full=S-100 protein alpha
DE   chain;AltName: Full=S-100 protein subunit alpha;AltName: Full=S100
DE   calcium-binding protein A1; (BOVIN3_19.PE21).
GN   Name=S100A1;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN3_19.PE21.
CC       Bos taurus chromosome 3 Btau_4.0 partial sequence 17642624..18642623
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10A1_BOVIN
CC   -!- FUNCTION: Weakly binds calcium but binds zinc very tightly-
CC       distinct binding sites with different affinities exist for both
CC       ions on each monomer. Physiological concentrations of potassium
CC       ion antagonize the binding of both divalent cations, especially
CC       affecting high-affinity calcium-binding sites.
CC   -!- SUBUNIT: Dimer of either two alpha chains, or two beta chains, or
CC       one alpha and one beta chain. Interacts with AGER and CAPZA1 (By
CC       similarity). Interacts with FKBP4 (By similarity).
CC   -!- TISSUE SPECIFICITY: Although predominant among the water-soluble
CC       brain proteins, S100 is also found in a variety of other tissues.
CC   -!- SIMILARITY: Belongs to the S-101 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- GENE_FAMILY: HOG000246968 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000000463;ENSBTAT00000046984;ENSBTAP00000044226.
DR   EMBL; BC141991; - ;
DR   EMBL; BC148019; - ;
DR   UniProtKB/Swiss-Prot; P02639; A5PJ73; -.
DR   EMBL; BC141991; AAI41992.1; -; mRNA.
DR   EMBL; BC148019; AAI48020.1; -; mRNA.
DR   IPI; IPI00717355; -.
DR   PIR; A24156; BCBOIA.
DR   RefSeq; NP_001092512.1; NM_001099042.1.
DR   RefSeq; XP_001253745.1; XM_001253744.3.
DR   UniGene; Bt.35032; -.
DR   UniGene; Bt.87250; -.
DR   PDB; 2JPT; NMR; -; A/B=2-94.
DR   PDBsum; 2JPT; -.
DR   ProteinModelPortal; P02639; -.
DR   SMR; P02639; 2-94.
DR   STRING; P02639; -.
DR   PRIDE; P02639; -.
DR   Ensembl; ENSBTAT00000006806; ENSBTAP00000006806; ENSBTAG00000005163.
DR   Ensembl; ENSBTAT00000046984; ENSBTAP00000044226; ENSBTAG00000000463.
DR   GeneID; 528735; -.
DR   GeneID; 786100; -.
DR   KEGG; bta:528735; -.
DR   KEGG; bta:786100; -.
DR   CTD; 6271; -.
DR   eggNOG; maNOG23090; -.
DR   GeneTree; ENSGT00600000084162; -.
DR   InParanoid; P02639; -.
DR   OMA; INVFHTH; -.
DR   OrthoDB; EOG4Z8XZ3; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR018248; EF-hand.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR001751; S100/CaBP-9k_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF00036; efhand; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   HOGENOMDNA; BOVIN3_19.PE21; -.
KW   ENSBTAG00000000463fold_1320000031; ENSBTAP00000044226fold_1320000031;
KW   BC141991; BC148019;
KW   3D-structure; Calcium; Complete proteome; Direct protein sequencing;
KW   Metal-binding; Reference proteome; Repeat; Zinc.
SQ   SEQUENCE   94 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKELLQT ELSGFLDAQK DADAVDKVMK
     ELDENGDGEV DFQEYVVLVA ALTVACNNFF WENS
//

If you have problems or comments...

PBIL Back to PBIL home page