(data stored in ACNUC27670 zone)

HOGENOM: BOVIN3_19_PE27

ID   BOVIN3_19_PE27                       STANDARD;      PRT;   98 AA.
AC   BOVIN3_19_PE27; P79342; Q3ZBJ2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A13;AltName: Full=8 kDa amlexanox-binding
DE   protein;AltName: Full=S100 calcium-binding protein A13; (BOVIN3_19.PE27).
GN   Name=S100A13;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN3_19.PE27.
CC       Bos taurus chromosome 3 Btau_4.0 partial sequence 17642624..18642623
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10AD_BOVIN
CC   -!- FUNCTION: Plays a role in the export of proteins that lack a
CC       signal peptide and are secreted by an alternative pathway. Binds
CC       two calcium ions per subunit. Binds one copper ion. Binding of one
CC       copper ion does not interfere with calcium binding. Required for
CC       the copper-dependent stress-induced export of IL1A and FGF1. The
CC       calcium-free protein binds to lipid vesicles containing
CC       phosphatidylserine, but not to vesicles containing
CC       phosphatidylcholine (By similarity).
CC   -!- SUBUNIT: Homodimer. Part of a copper-dependent multiprotein
CC       complex containing S100A13, FGF1 and SYT1. Interacts with FGF1 and
CC       SYT1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Secreted (By
CC       similarity). Note=Secretion is mediated by exposure to stress and
CC       requires copper ions (By similarity).
CC   -!- SIMILARITY: Belongs to the S-100 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- GENE_FAMILY: HOG000246968 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000021378;ENSBTAT00000028499;ENSBTAP00000028499.
DR   EMBL; AB001567; - ;
DR   EMBL; BC103266; - ;
DR   UniProtKB/Swiss-Prot; P79342; Q3ZBJ2; -.
DR   EMBL; AB001567; BAA19411.1; -; mRNA.
DR   EMBL; BC103266; AAI03267.1; -; mRNA.
DR   IPI; IPI00705400; -.
DR   RefSeq; NP_991369.1; NM_205800.1.
DR   RefSeq; XP_002703900.1; XM_002703854.1.
DR   RefSeq; XP_002703901.1; XM_002703855.1.
DR   UniGene; Bt.36848; -.
DR   ProteinModelPortal; P79342; -.
DR   SMR; P79342; 1-98.
DR   STRING; P79342; -.
DR   Ensembl; ENSBTAT00000028499; ENSBTAP00000028499; ENSBTAG00000021378.
DR   GeneID; 100335395; -.
DR   GeneID; 404146; -.
DR   KEGG; bta:100335395; -.
DR   KEGG; bta:404146; -.
DR   CTD; 6284; -.
DR   eggNOG; maNOG21030; -.
DR   GeneTree; ENSGT00530000063972; -.
DR   InParanoid; P79342; -.
DR   OMA; FTFAGRE; -.
DR   OrthoDB; EOG4G1MJ0; -.
DR   PhylomeDB; P79342; -.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
DR   GO; GO:0008144; F:drug binding; IDA:UniProtKB.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   GO; GO:0050703; P:interleukin-1 alpha secretion; ISS:UniProtKB.
DR   GO; GO:0043303; P:mast cell degranulation; NAS:UniProtKB.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; FALSE_NEG.
DR   PROSITE; PS50222; EF_HAND_2; FALSE_NEG.
DR   PROSITE; PS00303; S100_CABP; FALSE_NEG.
DR   HOGENOMDNA; BOVIN3_19.PE27; -.
KW   ENSBTAG00000021378fold_1320000031; ENSBTAP00000028499fold_1320000031;
KW   AB001567; BC103266;
KW   Calcium; Complete proteome; Copper; Cytoplasm; Lipid-binding;
KW   Metal-binding; Phosphoprotein; Protein transport; Reference proteome;
KW   Repeat; Secreted; Transport.
SQ   SEQUENCE   98 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAAEPLTELE AAIETVVTTF FTFAGREGRK GSLSVNEFKE LVTQQLPHLL KDVGSLDEKM
     KSLDVNQDSE LKFSEYWRLI GELAKEIRKE KALEIRKK
//

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