(data stored in ACNUC1829 zone)

HOGENOM: BOVIN5_113_PE30

ID   BOVIN5_113_PE30                      STANDARD;      PRT;   226 AA.
AC   BOVIN5_113_PE30; P30932; A6QLK0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD9 antigen;AltName: CD_antigen=CD9; (BOVIN5_113.PE30).
GN   Name=CD9;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN5_113.PE30.
CC       Bos taurus chromosome 5 Btau_4.0 partial sequence 110074943..111074942
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD9_BOVIN
CC   -!- FUNCTION: Involved in platelet activation and aggregation.
CC       Regulates paranodal junction formation. Involved in cell adhesion,
CC       cell motility and tumor metastasis. Required for sperm-egg fusion
CC       (By similarity).
CC   -!- SUBUNIT: Forms both disulfide-linked homodimers and higher
CC       homooligomers as well as heterooligomers with other members of the
CC       tetraspanin family. Associates with CR2/CD21 and with
CC       PTGFRN/CD9P1. Interacts directly with IGSF8 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- PTM: Phosphorylated on tyrosine following B-cell activation (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000014764;ENSBTAT00000019643;ENSBTAP00000019643.
DR   EMBL; BC147992; - ;
DR   EMBL; M81720; - ;
DR   UniProtKB/Swiss-Prot; P30932; A6QLK0; -.
DR   EMBL; M81720; AAA30439.1; -; mRNA.
DR   EMBL; BC147992; AAI47993.1; -; mRNA.
DR   IPI; IPI00686645; -.
DR   PIR; JX0221; JX0221.
DR   RefSeq; NP_776325.1; NM_173900.2.
DR   UniGene; Bt.2573; -.
DR   ProteinModelPortal; P30932; -.
DR   STRING; P30932; -.
DR   PRIDE; P30932; -.
DR   Ensembl; ENSBTAT00000019643; ENSBTAP00000019643; ENSBTAG00000014764.
DR   GeneID; 280746; -.
DR   KEGG; bta:280746; -.
DR   CTD; 928; -.
DR   eggNOG; maNOG13559; -.
DR   GeneTree; ENSGT00590000082836; -.
DR   InParanoid; P30932; -.
DR   OMA; CCAIRKS; -.
DR   OrthoDB; EOG402WT9; -.
DR   PhylomeDB; P30932; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; ISS:AgBase.
DR   GO; GO:0006928; P:cellular component movement; ISS:AgBase.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane; ISS:AgBase.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; ISS:AgBase.
DR   GO; GO:0030913; P:paranodal junction assembly; ISS:AgBase.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; BOVIN5_113.PE30; -.
KW   ENSBTAG00000014764fold_1320000031; ENSBTAP00000019643fold_1320000031;
KW   BC147992; M81720;
KW   Cell adhesion; Complete proteome; Disulfide bond; Fertilization;
KW   Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   226 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPVKGGTKCI KYLLFGFNFI FWLAGIAVLS VGLWLRFDSQ TKSIFEQENN DSSFYTGVYI
     LIGAGALMML VGFLGCCGAV QESQCMLGLF FSFLLVIFAI EVAAAIWGYS HKEEVIKEVQ
     KFYEDTYNKL KNKDEPQRET LKAIHIALDC CGLTGVPEQF LTDTCPPKNL IDSLKTRPCP
     EAIDEIFRSK FHIIGAVGIG IAVVMIFGMV FSMILCCAIR RNRDMV
//

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