(data stored in ACNUC10243 zone)

HOGENOM: BOVIN5_29_PE21

ID   BOVIN5_29_PE21                       STANDARD;      PRT;   320 AA.
AC   BOVIN5_29_PE21; P09867; Q2KJC4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Heterogeneous nuclear ribonucleoprotein A1; Short=hnRNP
DE   A1;AltName: Full=Helix-destabilizing protein;AltName: Full=Single-strand
DE   RNA-binding protein;AltName: Full=Unwinding protein 1; Short=UP1;AltName:
DE   Full=hnRNP core protein A1; (BOVIN5_29.PE21).
GN   Name=HNRNPA1; Synonyms=HNRPA1;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVIN5_29.PE21.
CC       Bos taurus chromosome 5 Btau_4.0 partial sequence 27667231..28667230
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ROA1_BOVIN
CC   -!- FUNCTION: Involved in the packaging of pre-mRNA into hnRNP
CC       particles, transport of poly(A) mRNA from the nucleus to the
CC       cytoplasm and may modulate splice site selection.
CC   -!- SUBUNIT: Identified in the spliceosome C complex. Identified in a
CC       mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG,
CC       HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU,
CC       HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4,
CC       PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2,
CC       YBX1 and untranslated mRNAs. Interacts with SEPT6 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localized in
CC       cytoplasmic mRNP granules containing untranslated mRNAs (By
CC       similarity). Shuttles continuously between the nucleus and the
CC       cytoplasm along with mRNA. Component of ribonucleosomes.
CC   -!- PTM: UP1 is derived from A1 by proteolytic degradation.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- PTM: Sumoylated (By similarity).
CC   -!- SIMILARITY: Contains 2 RRM (RNA recognition motif) domains.
CC   -!- GENE_FAMILY: HOG000234442 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000001553;ENSBTAT00000002033;ENSBTAP00000002033.
DR   EMBL; BC105413; - ;
DR   UniProtKB/Swiss-Prot; P09867; Q2KJC4; -.
DR   EMBL; BC105413; AAI05414.1; -; mRNA.
DR   IPI; IPI00692235; -.
DR   PIR; A27241; A27241.
DR   RefSeq; NP_001039376.1; NM_001045911.1.
DR   UniGene; Bt.88002; -.
DR   ProteinModelPortal; P09867; -.
DR   SMR; P09867; 8-190.
DR   STRING; P09867; -.
DR   PRIDE; P09867; -.
DR   Ensembl; ENSBTAT00000002033; ENSBTAP00000002033; ENSBTAG00000001553.
DR   GeneID; 505093; -.
DR   KEGG; bta:505093; -.
DR   CTD; 3178; -.
DR   eggNOG; maNOG13969; -.
DR   GeneTree; ENSGT00550000074566; -.
DR   OrthoDB; EOG4HQDKF; -.
DR   PhylomeDB; P09867; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR021662; HnRNPA1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF11627; HnRNPA1; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   SMART; SM00360; RRM; 2.
DR   PROSITE; PS50102; RRM; 2.
DR   HOGENOMDNA; BOVIN5_29.PE21; -.
KW   ENSBTAG00000001553fold_1320000031; ENSBTAP00000002033fold_1320000031;
KW   BC105413;
KW   Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing;
KW   Isopeptide bond; Methylation; mRNA processing; mRNA splicing;
KW   mRNA transport; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Ribonucleoprotein; RNA-binding; Spliceosome; Transport;
KW   Ubl conjugation.
SQ   SEQUENCE   320 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV
     TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH
     LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA
     LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS
     GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR
     NQGGYGGSSS SSSYGSGRRF
//

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