(data stored in ACNUC17706 zone)

HOGENOM: BOVINX_22_PE8

ID   BOVINX_22_PE8                        STANDARD;      PRT;   664 AA.
AC   BOVINX_22_PE8; Q03041;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Cyclic nucleotide-gated olfactory channel;AltName:
DE   Full=Cyclic nucleotide-gated cation channel 2;AltName: Full=Cyclic
DE   nucleotide-gated channel alpha-2; Short=CNG channel alpha-2; Short=CNG-2;
DE   Short=CNG2; (BOVINX_22.PE8).
GN   Name=CNGA2; Synonyms=CNCG2;
OS   BOS TAURUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BOVINX_22.PE8.
CC       Bos taurus chromosome X Btau_4.0 partial sequence 20946402..21946401
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CNGA2_BOVIN
CC   -!- FUNCTION: Odorant signal transduction is probably mediated by a G-
CC       protein coupled cascade using cAMP as second messenger. The
CC       olfactory channel can be shown to be activated by cyclic
CC       nucleotides which leads to a depolarization of olfactory sensory
CC       neurons.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Olfactory neurons.
CC   -!- MISCELLANEOUS: The olfactory channel is activated by both cAMP and
CC       cGMP at similar concentrations, whereas the cGMP-gated channel is
CC       much less sensitive to cAMP.
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide-gated cation channel
CC       (TC 1.A.1.5) family. CNGA2 subfamily.
CC   -!- SIMILARITY: Contains 1 cyclic nucleotide-binding domain.
CC   -!- GENE_FAMILY: HOG000007898 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Bos_taurus;ENSBTAG00000020725;ENSBTAT00000027618;ENSBTAP00000027618.
DR   EMBL; X55010; - ;
DR   UniProtKB/Swiss-Prot; Q03041; -.
DR   EMBL; X55010; CAA38754.1; -; mRNA.
DR   IPI; IPI00693519; -.
DR   PIR; S11521; S11521.
DR   RefSeq; NP_001001139.1; NM_001001139.1.
DR   UniGene; Bt.28014; -.
DR   PDB; 1SY9; NMR; -; B=60-85.
DR   PDBsum; 1SY9; -.
DR   ProteinModelPortal; Q03041; -.
DR   PRIDE; Q03041; -.
DR   GeneID; 407172; -.
DR   KEGG; bta:407172; -.
DR   CTD; 1260; -.
DR   eggNOG; maNOG08675; -.
DR   GeneTree; ENSGT00550000074376; -.
DR   InParanoid; Q03041; -.
DR   OrthoDB; EOG4N5VWD; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; ISS:AgBase.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; ISS:AgBase.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Gene3D; G3DSA:2.60.120.10; RmlC-like_jellyroll; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cNMP_binding; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   HOGENOMDNA; BOVINX_22.PE8; -.
KW   ENSBTAG00000020725fold_1320000031; ENSBTAP00000027618fold_1320000031;
KW   X55010;
KW   3D-structure; cAMP; cAMP-binding; Complete proteome; Glycoprotein;
KW   Ion transport; Ionic channel; Ligand-gated ion channel; Membrane;
KW   Nucleotide-binding; Olfaction; Reference proteome;
KW   Sensory transduction; Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   664 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     RMTEKANGVK SSPANNHNHH APPAIKASGK DDHRASSRPQ SAADDDTSSE LQRLAEMDAP
     QQRRGGFRRI ARLVGVLREW AYRNFREEEP RPDSFLERFR GPELHTVTTQ QGDGKGDKDG
     EGKGTKKKFE LFVLDPAGDW YYRWLFLIAL PVLYNWCLLV ARACFSDLQK GYYIVWLVLD
     YVSDVVYIAD LFIRLRTGFL EQGLLVKDTK KLRDNYIHTM QFKLDVASII PTDLIYFAVG
     IHNPEVRFNR LLHFARMFEF FDRTETRTSY PNIFRISNLI LYILIIIHWN ACIYYAISKS
     IGFGVDTWVY PNITDPEYGY LSREYIYCLY WSTLTLTTIG ETPPPVKDEE YLFVIFDFLI
     GVLIFATIVG NVGSMISNMN ATRAEFQAKI DAVKHYMQFR KVSKEMEAKV IRWFDYLWTN
     KKSVDEREVL KNLPAKLRAE IAINVHLSTL KKVRIFQDCE AGLLVELVLK LRPQVFSPGD
     YICRKGDIGK EMYIIKEGKL AVVADDGVTQ YALLSAGSCF GEISILNIKG SKMGNRRTAN
     IRSLGYSDLF CLSKDDLMEA VTEYPDAKRV LEERGREILM KEGLLDENEV AASMEVDVQE
     KLEQLETNMD TLYTRFARLL AEYTGAQQKL KQRITVLETK MKQNNEDDSL SDGMNSPEPP
     AEKP
//

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