(data stored in SCRATCH3701 zone)

HOGENOM6: BRAHW_1_PE981

ID   BRAHW_1_PE981                        STANDARD;      PRT;   834 AA.
AC   BRAHW_1_PE981; C0R046;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3; (BRAHW_1.PE981).
GN   Name=gyrA; OrderedLocusNames=BHWA1_01001;
OS   BRACHYSPIRA HYODYSENTERIAE WA1.
OC   Bacteria; Spirochaetes; Spirochaetales; Brachyspiraceae; Brachyspira.
OX   NCBI_TaxID=565034;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BRAHW_1.PE981.
CC       Brachyspira hyodysenteriae WA1, complete genome.
CC       1..5047 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:GYRA_BRAHW
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C0R046; -.
DR   EMBL; CP001357; ACN83484.1; -; Genomic_DNA.
DR   RefSeq; YP_002721188.1; NC_012225.1.
DR   STRING; C0R046; -.
DR   GeneID; 7666102; -.
DR   GenomeReviews; CP001357_GR; BHWA1_01001.
DR   KEGG; bhy:BHWA1_01001; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; CLSK2809833; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 2.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; BRAHW_1.PE981; -.
DR   PRODOM; BRAHW_1_PE981.
DR   SWISS-2DPAGE; BRAHW_1_PE981.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   834 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAVKKNKEDN SEERQYSTLT KDILKRVDHI SIENELRESY LTYAMSVIVS RALPDVRDGL
     KPVHRRILYA MYDANLTHDK PYKKSAATVG EVLARYHPHG DAAVYGTMVR MAQDFSMRYL
     LVDGQGNFGS IDDDPPAAMR YTEARMTRFA EEMLNDIEKE TVKFVPNFDD SRTEPSVLPA
     TVPQLLVNGS MGIAIGMATN MPPHNLKEVV NAIVYYIDHQ DAEIKDLMRY VQGPDFPTAG
     IIYGKEGIKE AYTTGKGRIK LRARLEVEET KRDREAIVVK ELPYGVVKTT LHEKIADLVK
     QGKIEGVADI RDESSNRAGI RLIIELKKGV ATQIVLNQLW KHTDLETTFG IINLALVNGE
     PKVLNLKELI KYFVDHRVEV ITKRTEYDLN QAKAKAHILE GLLIAQANIE EVIRIIRESE
     NTDAARTTLM NRFKLSEKQA QAILDMPLKR LTALEKLKIE QELQQLREFI AYCEDLLAHP
     EKILAVIKDE LKKISEKYGD DRRSEIIGKT NDTEIDEEDL IHDEDVAVSI TTQGFIKRVP
     ASSYRTQGRG GVGVQGGKSQ GEHYIEHLFV ASTKDYLFIF TDRGKAFWMK VHEIPALSKI
     SQGKSIKFIL NLAPEEKITS YFTVSEFDPK QSIIMVTKMG TIKKMELKHL ENAKKRGILA
     LTLENNDELV AVSPVQTGDD FIMTTAAGLA LRITEEKIRK MGRAAAGVKG ISLDDDDICV
     SGNAIHKGES LIVITENGIG KRLSSKQFNV KGRGGKGQIY IKPDNKTGNV VSVKTVGDKD
     EIMVVTTDDM TIKIKADSIP ELGRNAKGVK IVNISDGARV SDLAVVPADN EEKK
//

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