(data stored in SCRATCH3701 zone)

HOGENOM6: BUPSE2_1_PE3023

ID   BUPSE2_1_PE3023                      STANDARD;      PRT;   888 AA.
AC   BUPSE2_1_PE3023; C4KS74;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (BUPSE2_1.PE3023).
GN   Name=gyrA; ORFNames=GBP346_A3068;
OS   BURKHOLDERIA PSEUDOMALLEI MSHR346.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=536230;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BUPSE2_1.PE3023.
CC       Burkholderia pseudomallei MSHR346 chromosome I, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:C4KS74_BURPS
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C4KS74; -.
DR   EMBL; CP001408; ACQ95370.1; -; Genomic_DNA.
DR   RefSeq; YP_002897752.1; NC_012695.1.
DR   ProteinModelPortal; C4KS74; -.
DR   SMR; C4KS74; 52-552, 566-873.
DR   STRING; C4KS74; -.
DR   GeneID; 7889402; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; BUPSE2_1.PE3023; -.
DR   PRODOM; BUPSE2_1_PE3023.
DR   SWISS-2DPAGE; BUPSE2_1_PE3023.
KW   ATP-binding; Cytoplasm; DNA-binding; Isomerase; Nucleotide-binding;
KW   Topoisomerase.
SQ   SEQUENCE   888 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRRASGAHAK GGPVFAPKRY GYMDQFAKET LPTSLEEEMR KSYLDYAMSV IVGRALPDVR
     DGLKPVHRRV LFAMHELNND WNRPYKKSAR IVGDVIGKYH PHGDTAVYDT IVRMAQDFSL
     RYMLVDGQGN FGSVDGDNAA AMRYTEIRMA KIGHELLADI DKETVDFGPN YDGSEMQPLI
     LPSRIPNLLI NGSSGIAVGM ATNIPPHNLN EVVDACLYLL NNPQASVDEL IEIIPAPDFP
     TAGIIYGVAG VRDGYRTGRG RVVMRAATHF EEIDRGQRMA IIVDELPYQV NKRSLLERIA
     ELVNEKKLEG ISDIRDESDK SGMRVVIELK RGEVPEVVLN NLYKATQLQD TFGMNMVALV
     DNQPKLLNLR EILQCFLSHR REVLTRRTVY ELRKARERGH VLEGLAVALA NIDEFIAIIK
     AAPTPPIAKQ ELMAKSWDSS LVRDMLTRAE TENAAAGGRD AYRPEGLSPA FGMQGDGLYR
     LSDTQAQEIL QMRLQRLTGL EQDKIIGEYR DVMAQIADLL DILARPERIT TLIGDELTQV
     KAEFGDARRS KIELNATELN TEDLITPQDM VVTMSHAGYV KSQPLSEYRA QKRGGRGKQA
     TQMKEDDWIE TLFIANTHDY ILCFSNRGRV YWVKVYEVPQ GSRNSRGRPI VNMFPLQDGE
     KINVVLPVKE FSADKYVFMT TALGTVKKTP LEAFSRPMKK GIIAVGLDDG DYLIGAAITD
     GAHDVMLFSD AGKAVRFDEN DVRPMGREAR GVRGMQLDDA QQVIAMLVAG SEEQSVLTAT
     ENGYGKRTPI TEYTRHGRGT KGMIAIQTSE RNGRVVAATL VDPEDQIMLI TTAGVLIRTR
     VSEIREMGRA TQGVTLISLD EGTKLSGLQQ IAEADADADD DAVEGGDA
//

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