(data stored in ACNUC7421 zone)

HOGENOM: BURP8_1_PE1014

ID   BURP8_1_PE1014                       STANDARD;      PRT;   1359 AA.
AC   BURP8_1_PE1014; B2JGM6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Phosphoribosylformylglycinamidine synthase; EC=6.3.5 3;
DE   (BURP8_1.PE1014).
GN   OrderedLocusNames=Bphy_1022;
OS   BURKHOLDERIA PHYMATUM STM815.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=391038;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BURP8_1.PE1014.
CC       Burkholderia phymatum STM815 chromosome chromosome 1, complete sequence
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:B2JGM6_BURP8
CC   -!- CATALYTIC ACTIVITY: ATP + N(2)-formyl-N(1)-(5-phospho-D-
CC       ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-
CC       (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 1/2.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.
CC   -!- GENE_FAMILY: HOG000261359 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B2JGM6; -.
DR   EMBL; CP001043; ACC70211.1; -; Genomic_DNA.
DR   RefSeq; YP_001857257.1; NC_010622.1.
DR   ProteinModelPortal; B2JGM6; -.
DR   STRING; B2JGM6; -.
DR   GeneID; 6242520; -.
DR   GenomeReviews; CP001043_GR; Bphy_1022.
DR   KEGG; bph:Bphy_1022; -.
DR   OMA; VKAVGME; -.
DR   ProtClustDB; PRK05297; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:HAMAP.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004642; F:phosphoribosylformylglycinamidine synthase activity; IEA:HAMAP.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00419; PurL_1; 1; -.
DR   InterPro; IPR000728; AIR_synth.
DR   InterPro; IPR010918; AIR_synth_C.
DR   InterPro; IPR017926; GATASE_1.
DR   InterPro; IPR010073; PRibForGlyAmidine_synth.
DR   InterPro; IPR022940; PRibForGlyAmidine_synth_bac.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 2.
DR   SUPFAM; SSF56042; AIR_synth_C; 2.
DR   SUPFAM; SSF55326; PurM_N-like; 2.
DR   TIGRFAMs; TIGR01735; FGAM_synt; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
DR   HOGENOMDNA; BURP8_1.PE1014; -.
KW   phosphoribosylformylglycinamidine synthase;
KW   ATP-binding; Complete proteome; Cytoplasm; Glutamine amidotransferase;
KW   Ligase; Nucleotide-binding; Purine biosynthesis.
SQ   SEQUENCE   1359 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAHFSCFPGA SALSDFRQTR LLDTLSRIDA SIVGVRGQYL HFVNSQTPLS SEDSAKIEAL
     MHYGDPFDAG KDKGAAETFL VVPRFGTVSP WASKATDIAH HCGLAHVRRI ERGVEYTVVL
     KGGLLGGKKA LSEAARAAVV AALHDRMTES VAPSRDHAMH LFDELPAKPL QTVGVLTDGR
     QALEKANSEL GLALADDEID YLADAFTKLG RNPTDVELMM FAQANSEHCR HKIFNASWTI
     DGETQDMSLF NMIRNTEKLN PQGTIVAYSD NSSIMQGGMA ERWFPRKPAH ADELGERYGR
     HTELTHTLMK VETHNHPTAI SPFPGAATGA GGEIRDEGAT GRGARPKAGL TGFTVSNLEL
     PDAREPWENA RDANQPVGHR NAADQFATYG RPDRIASPLQ IMIDGPLGGA AFNNEFGRPN
     LGGYFRTYEQ NVAGRVRGYH KPIMIAGGLG NVSDQHTHKH DLPAGSLLIQ IGGPGMRIGM
     GGGAASSMAT GTNTAELDFD SVQRGNPEIE RRAQEVINSC WQLGEGNPIL SIHDVGAGGL
     SNAFPELVDG ADKGALFELR KIQLEESGLS PREIWSNEAQ ERYVLAIPPT RLEEFAAICE
     RERCPFAVVG AATAERQLKL IDADKADGSA HEPVDMPMEV LLGKPPRMHR DVKRESTPLQ
     PVDVTHIALH EAAVNVLRHP TVASKSFLIT IGDRSVGGTT ARDQMVGPWQ VPVADCAITT
     VDYAGFRGEA MTMAERTPLA VIDAPASGRM AVGEAVTNIA SAPIASLDKL KLSANWMAAC
     GSPGEDAALY DTVKAIGMEL CPALGIGIPV GKDSLSMRTK WADGNVEKEV VAPVSLIISA
     FAPVEDVRRH LTPQLMSVRE AGETVLIAID LGRGKQRLGG SILAQVTQQV GDTVPDVDDA
     EDLKRFFAAI QALNADGKLL AYHDRSDGGL WTTVCEMAFA GHVGVSLNVD MLTLDPDHEF
     DYGDAKDWTK QTSGRREDRT IRALFNEELG AVVQVRAADR DAVLAALREH GLSACSHVIG
     KPNTNDMIEI YRDAKKIFDA PRAELHRTWS EVSWRIARLR DNPACADAEF EMLLDTADPG
     MQPHLSFDPV EDVAAPFVGK GARPRVAILR EQGVNSHLET AYAFDRAGFD AHDVHMSDLL
     SGRATLADFA GAVACGGFSY GDVLGAGEGW AKTIRFNAQL ADMFAAFFGR SDTFALGICN
     GCQMMSSLAS MIPGADAWPK FTRNKSEKFE ARFSLVEVQS SPSIFFAGME SSRIPVAVAH
     GEGFADFSQQ GDASRVAVAL RYVDHRGQPT EQYPFNPNGS PAGITSVTTP DGRFTVLMPH
     TERVHRNVQM SWHPQAWKES ATDGSPWMRV FQNARKWLG
//

If you have problems or comments...

PBIL Back to PBIL home page