(data stored in ACNUC7421 zone)

HOGENOM: BURXL_1_PE1012

ID   BURXL_1_PE1012                       STANDARD;      PRT;   431 AA.
AC   BURXL_1_PE1012; Q143D9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Seryl-tRNA synthetase; EC=6.1.1 11;AltName:
DE   Full=Serine--tRNA ligase; Short=SerRS;AltName: Full=Seryl-tRNA(Ser/Sec)
DE   synthetase; (BURXL_1.PE1012).
GN   Name=serS; OrderedLocusNames=Bxeno_A1012; ORFNames=Bxe_A3435;
OS   BURKHOLDERIA XENOVORANS LB400.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=266265;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS BURXL_1.PE1012.
CC       Burkholderia xenovorans LB400 chromosome 1, complete sequence.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:SYS_BURXL
CC   -!- FUNCTION: Catalyzes the attachment of serine to tRNA(Ser). Is also
CC       able to aminoacylate tRNA(Sec) with serine, to form the
CC       misacylated tRNA L-seryl-tRNA(Sec), which will be further
CC       converted into selenocysteinyl-tRNA(Sec) (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + L-serine + tRNA(Ser) = AMP + diphosphate
CC       + L-seryl-tRNA(Ser).
CC   -!- CATALYTIC ACTIVITY: ATP + L-serine + tRNA(Sec) = AMP + diphosphate
CC       + L-seryl-tRNA(Sec).
CC   -!- PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec)
CC       biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step
CC       1/1.
CC   -!- SUBUNIT: Homodimer. The tRNA molecule binds across the dimer (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- DOMAIN: Consists of two distinct domains, a catalytic core and a
CC       N-terminal extension that is involved in tRNA binding (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase
CC       family. Type-1 seryl-tRNA synthetase subfamily.
CC   -!- GENE_FAMILY: HOG000035938 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q143D9; -.
DR   EMBL; CP000270; ABE29550.1; -; Genomic_DNA.
DR   RefSeq; YP_557602.1; NC_007951.1.
DR   ProteinModelPortal; Q143D9; -.
DR   SMR; Q143D9; 1-426.
DR   STRING; Q143D9; -.
DR   GeneID; 4002312; -.
DR   GenomeReviews; CP000270_GR; Bxeno_A1012.
DR   KEGG; bxe:Bxe_A3435; -.
DR   OMA; PKFADDM; -.
DR   ProtClustDB; PRK05431; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004828; F:serine-tRNA ligase activity; IEA:EC.
DR   GO; GO:0006434; P:seryl-tRNA aminoacylation; IEA:InterPro.
DR   HAMAP; MF_00176; Ser_tRNA_synth_type1; 1; -.
DR   InterPro; IPR002314; aa-tRNA-synt_IIb_cons-dom.
DR   InterPro; IPR006195; aa-tRNA-synth_II.
DR   InterPro; IPR002317; Ser-tRNA-synth_IIa.
DR   InterPro; IPR015866; Ser-tRNA-synth_IIa_N.
DR   InterPro; IPR010978; tRNA-bd_arm.
DR   Gene3D; G3DSA:1.10.287.40; Ser-tRNA-synth_IIa_N; 1.
DR   PANTHER; PTHR11778; tRNA-synt_ser; 1.
DR   Pfam; PF02403; Seryl_tRNA_N; 1.
DR   Pfam; PF00587; tRNA-synt_2b; 1.
DR   PIRSF; PIRSF001529; Ser-tRNA-synth_IIa; 1.
DR   PRINTS; PR00981; TRNASYNTHSER.
DR   SUPFAM; SSF46589; tRNA_binding_arm; 1.
DR   TIGRFAMs; TIGR00414; SerS; 1.
DR   PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
DR   HOGENOMDNA; BURXL_1.PE1012; -.
KW   seryl-tRNA synthetase;
KW   Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Protein biosynthesis.
SQ   SEQUENCE   431 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLDIQLLRKD LDGVAKRLAD RGYTLDVAAF TALEAERRDT QTRTEEMQAR RNSLSKQIGA
     LKGKGEDTSA VMAEVSGIGD EMKASAARLD EIQKRLSDLL LGVPNLPHES VPLGKDETEN
     VEVRRWGTPR QFEFEVKDHV DVGAPLGLDF ETGAKLSGAR FTMLRGQIAR LHRALAQFMI
     DTHTQHHGYT EIYTPYIVNP EILYGTGQLP KFADDMFRVE KGGDENTVTQ YLISTSEISL
     TNTVRDSILE ADALPIKLTA HSPCFRSEAG SYGRDTRGLI RQHQFDKVEM VQIVAPETSY
     DALEQMVGHA ETILQKLELP YRVITLCTGD MGFSAAKTYD LEVWVPAQNT YREISSCSNT
     ESFQARRMQA RYRNAQGKPE LVHTLNGSGL AVGRTLVAVL ENFQNADGSV TVPVALRPYL
     GGLERLELPA A
//

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