(data stored in ACNUC30567 zone)

HOGENOM: CAEELIII_PE1001

ID   CAEELIII_PE1001                      STANDARD;      PRT;   281 AA.
AC   CAEELIII_PE1001; Q09253;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Glyoxalase 1; Short=CeGly;AltName: Full=Glyoxalase
DE   domain-containing protein 4; (CAEELIII.PE1001).
GN   Name=glod-4; Synonyms=tag-73; ORFNames=C16C10.10;
OS   CAENORHABDITIS ELEGANS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda;
OC   Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAEELIII.PE1001.
CC       Caenorhabditis elegans chromosome III WS210  sequence 1..13783685
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:GLOD4_CAEEL
CC   -!- FUNCTION: Thought to act as a glyoxalase. May remove methylglyoxal
CC       from mitochondrial proteins. Has roles in reducing oxidative
CC       stress and increasing lifespan.
CC   -!- TISSUE SPECIFICITY: Expressed in the following tissues in both
CC       larvae and adults: pharynx, pharyngeal-intestinal valve,
CC       intestine, anal sphincter, vulval muscle, seam cells and the
CC       nervous system.
CC   -!- DEVELOPMENTAL STAGE: Expression increases from day 1 to day 12 but
CC       activity decreased 10-fold during this period indicating that post
CC       translational modification is operational.
CC   -!- SIMILARITY: Belongs to the glyoxalase I family.
CC   -!- GENE_FAMILY: HOG000006776 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Caenorhabditis_elegans;C16C10.10;C16C10.10;C16C10.10.
DR   EMBL; Z46787; - ;
DR   UniProtKB/Swiss-Prot; Q09253; -.
DR   EMBL; Z46787; CAA86748.1; -; Genomic_DNA.
DR   PIR; T19331; T19331.
DR   RefSeq; NP_497827.1; NM_065426.1.
DR   UniGene; Cel.10826; -.
DR   ProteinModelPortal; Q09253; -.
DR   SMR; Q09253; 3-129, 132-250.
DR   STRING; Q09253; -.
DR   PRIDE; Q09253; -.
DR   EnsemblMetazoa; C16C10.10; C16C10.10; C16C10.10.
DR   GeneID; 175530; -.
DR   KEGG; cel:C16C10.10; -.
DR   NMPDR; fig|6239.3.peg.9308; -.
DR   CTD; 175530; -.
DR   WormBase; C16C10.10; CE01490; WBGene00006448; glod-4.
DR   eggNOG; meNOG05834; -.
DR   GeneTree; EMGT00050000014080; -.
DR   InParanoid; Q09253; -.
DR   OMA; YRLGNDF; -.
DR   PhylomeDB; Q09253; -.
DR   NextBio; 888544; -.
DR   ArrayExpress; Q09253; -.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
DR   GO; GO:0009438; P:methylglyoxal metabolic process; IMP:UniProtKB.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   HOGENOMDNA; CAEELIII.PE1001; -.
KW   C16C10.10310200367fold_1320000031; C16C10.10.22210.62fold_1320000031;
KW   Z46787;
KW   Complete proteome; Reference proteome.
SQ   SEQUENCE   281 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTARALHYVF KVANRAKTID FFTNVLNMKV LRHEEFEKGC EATCNGPYNG RWSKTMIGYG
     SEDEHFVLEI TYNYPIHKYE LGNDYRAIVI DSDQLFEKVE KINHRKSGCG RLAVKDPDGH
     EFKIGKADQS PKVLRVQVNV GDLEKSKKYW NETLGMPIVE EKSSRIRMSY GDGQCELEIV
     KSQDKIDRKT GFGRIAFSYP EDKLESLQDK IKSANGTIIN ELTTLETPGK ADVQVVILAD
     PDEHEICFVG DEGFRALSKI DDKAESELKE QIKKDDSEKW I
//

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