(data stored in ACNUC21049 zone)

HOGENOM: CAEELIV_PE3551

ID   CAEELIV_PE3551                       STANDARD;      PRT;   1134 AA.
AC   CAEELIV_PE3551; Q21554;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA damage-binding protein 1;AltName: Full=Damage-specific
DE   DNA-binding protein 1; (CAEELIV.PE3551).
GN   Name=ddb-1; ORFNames=M18.5;
OS   CAENORHABDITIS ELEGANS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda;
OC   Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAEELIV.PE3551.
CC       Caenorhabditis elegans chromosome IV WS210  sequence 1..17493784
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:DDB1_CAEEL
CC   -!- FUNCTION: Plays a role in DNA repair. May be a component of an E3
CC       ubiquitin-protein ligase which promotes histone ubiquitination in
CC       response to UV irradiation. Histone ubiquination may be important
CC       for subsequent DNA repair (By similarity). Promotes the
CC       degradation of the replication licensing factor cdt-1 during S-
CC       phase, thereby preventing rereplication of DNA during a single
CC       round of cell division.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with cdt-1 and cul-4.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in the spermatheca of
CC       adult hermaphrodites.
CC   -!- DEVELOPMENTAL STAGE: Expressed in proliferating larval blast cells
CC       including seam cells in the lateral hypodermis, P cells in the
CC       ventral hypodermis, and intestinal cells. Within the P cell
CC       lineage expression levels correlate with the proliferative state,
CC       being low in newly hatched larvae and then increasing in L1 as P
CC       cells begin to proliferate. Not expressed in the adult cells of
CC       the P lineage which are postmitotic. Also expressed in some non-
CC       proliferating cells such as the lateral hyp7 hypodermal cells,
CC       rectal gland and epithelial cells, and a subset of neuronal cells
CC       in the head and tail regions.
CC   -!- SIMILARITY: Belongs to the DDB1 family.
CC   -!- GENE_FAMILY: HOG000007241 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Caenorhabditis_elegans;M18.5;M18.5;M18.5.
DR   EMBL; Z68507; - ;
DR   UniProtKB/Swiss-Prot; Q21554; -.
DR   EMBL; Z68507; CAA92824.2; -; Genomic_DNA.
DR   PIR; A88855; A88855.
DR   PIR; T23798; T23798.
DR   RefSeq; NP_502299.1; NM_069898.6.
DR   UniGene; Cel.5138; -.
DR   HSSP; Q16531; 2B5L.
DR   ProteinModelPortal; Q21554; -.
DR   DIP; DIP-25884N; -.
DR   IntAct; Q21554; 3.
DR   MINT; MINT-1055778; -.
DR   STRING; Q21554; -.
DR   EnsemblMetazoa; M18.5.1; M18.5.1; M18.5.
DR   EnsemblMetazoa; M18.5.2; M18.5.2; M18.5.
DR   GeneID; 178156; -.
DR   KEGG; cel:M18.5; -.
DR   NMPDR; fig|6239.3.peg.15399; -.
DR   UCSC; M18.5; c. elegans.
DR   CTD; 178156; -.
DR   WormBase; M18.5; CE23880; WBGene00010890; ddb-1.
DR   eggNOG; meNOG05056; -.
DR   GeneTree; EMGT00050000015936; -.
DR   InParanoid; Q21554; -.
DR   OMA; CALGDGS; -.
DR   PhylomeDB; Q21554; -.
DR   NextBio; 899950; -.
DR   ArrayExpress; Q21554; -.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0007276; P:gamete generation; IMP:WormBase.
DR   GO; GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR   GO; GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
DR   GO; GO:0030163; P:protein catabolic process; IMP:WormBase.
DR   GO; GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR011047; Quinonprotein_ADH-like.
DR   Pfam; PF03178; CPSF_A; 1.
DR   SUPFAM; SSF50998; Quin_alc_DH_like; 1.
DR   HOGENOMDNA; CAEELIV.PE3551; -.
KW   M18.50.41400200367fold_1320000031; M18.50.4a32.110.62fold_1320000031;
KW   Z68507;
KW   Cell cycle; Complete proteome; Cytoplasm; DNA damage; DNA repair;
KW   DNA-binding; Nucleus; Reference proteome; Ubl conjugation pathway.
SQ   SEQUENCE   1134 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPISYCVSAK KASVVVESVV GNFTGHENVN LIVARGNRID VQLVSPEGLK NVCEIPIYGQ
     VLTIALVKCK RDKRHSLIVV TEKWHMAILA YRDGKVVTRA AGCIADPTGR ATDNLFSLTI
     HRNGLIAIRA FEGSVKMIQW ESGTDLRHFN VRFDYPNVSD FKFVDTGEDD VYRVAFIYDD
     DHGKHLQFSD LNMHDKEFRT YSRQASIAAD SSVLIPVPHA IGGVIVLGSN SVLYKPNDNL
     GEVVPYTCSL LENTTFTCHG IVDASGERFL LSDTDGRLLM LLLNVTESQS GYTVKEMRID
     YLGETSIADS INYIDNGVVF VGSRLGDSQL IRLMTEPNGG SYSVILETYS NIGPIRDMVM
     VESDGQPQLV TCTGADKDGS LRVIRNGIGI DELASVDLAG VVGIFPIRLD SNADNYVIVS
     LSDETHVLQI TGEELEDVKL LEINTDLPTI FASTLFGPND SGIILQATEK QIRLMSSSGL
     SKFWEPTNGE IISKVSVNAA NGQIVLAARD TVYLLTCIVD EMGALDIQLT AEKKFENEIA
     CLDLSNEGDD PNNKATFLVL AFWSTFAMEV IQLPDLITVC HTDLPTKIIP RSIIATCIEE
     VHYLLVAFGD GALVYYVFDI KTGTHGEPKK SNVGTRPPSL HRVRNKNRQH LFVCSDRPVI
     IFSASKKLVF SNVNVKLVDT VCSLSSSAYR DCLVISDGNS MVFGTVDDIQ KIHVRSIPMG
     ESVLRIAYQK STSTYGVCSN RTESKAERVF ASKNALVTSQ SRPKVASTRA DMDESPPNTT
     SSFMVLDQNT FQVLHSHEFG PWETALSCIS GQFTNDSSTY YVVGTGLIYP DETETKIGRI
     VVFEVDDVER SKLRRVHELV VRGSPLAIRI LNGKLVAAIN SSIRLFEWTT DKELRLECSS
     FNHVIALDLK VMNEEVAVAD VMRSVSLLSY RMLEGNFEEV AKDWNSQWMV TCEFITAESI
     LGGEAHLNLF TVEVDKTRPI TDDGRYVLEP TGYWYLGELP KVMTRSTLVI QPEDSIIQYS
     QPIMFGTNQG TIGMIVQIDD KWKKFLIAIE KAIADSVKNC MHIEHSSYRT FVFQKRAEPP
     SGFVDGDLVE SILDMDRSVA MDILSKVSDK GWDPSLPRDP VEILKVIEDL ARMH
//

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