(data stored in ACNUC13749 zone)

HOGENOM: CAEELI_PE257

ID   CAEELI_PE257                         STANDARD;      PRT;   590 AA.
AC   CAEELI_PE257; Q9Y048; Q9TZI6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dystrobrevin-1; (CAEELI.PE257).
GN   Name=dyb-1; ORFNames=F47G6.1;
OS   CAENORHABDITIS ELEGANS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda;
OC   Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAEELI.PE257.
CC       Caenorhabditis elegans chromosome I WS210  sequence 1..15072421
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:DTN1_CAEEL
CC   -!- FUNCTION: Plays a role in cholinergic transmission and as a
CC       functional partner of dystrophin (dys-1), necessary for muscle
CC       maintenance.
CC   -!- SUBUNIT: Component of the dystrophin glycoprotein complex (DGC).
CC       Interacts with dys-1 and syntrophin (stn-1) to form the DGC.
CC   -!- INTERACTION:
CC       Q9TW65:dys-1; NbExp=4; IntAct=EBI-322698, EBI-446952;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: From late embryogenesis to adulthood,
CC       expressed in neurons and muscles; particularly strong in the
CC       ventral nerve cord and in muscles of the body wall, head
CC       pharyngeal, and vulva; weaker in the intestinal muscle (at protein
CC       level).
CC   -!- DOMAIN: The coiled-coil domain mediates the specific interaction
CC       with dys-1.
CC   -!- DISRUPTION PHENOTYPE: Mutants synergistically exhibit progressive
CC       myopathy. In dyb-1;hlh-1 double mutants there is an uncoordinated
CC       phenotype associated with some muscle degeneration. Overexpression
CC       of dyb-1 in dys-1;hlh-1 double mutants delays, but does not
CC       prevent the onset and progression of myopathy.
CC   -!- SIMILARITY: Belongs to the dystrophin family. Dystrobrevin
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 ZZ-type zinc finger.
CC   -!- GENE_FAMILY: HOG000230684 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Caenorhabditis_elegans;F47G6.1;F47G6.1;F47G6.1.
DR   EMBL; AF098989; - ;
DR   EMBL; AJ131742; - ;
DR   UniProtKB/Swiss-Prot; Q9Y048; Q9TZI6; -.
DR   EMBL; AJ131742; CAA10498.1; -; mRNA.
DR   EMBL; AF098989; AAK18956.2; -; Genomic_DNA.
DR   RefSeq; NP_490860.1; NM_058459.4.
DR   UniGene; Cel.19602; -.
DR   ProteinModelPortal; Q9Y048; -.
DR   SMR; Q9Y048; 6-313.
DR   DIP; DIP-25663N; -.
DR   IntAct; Q9Y048; 26.
DR   MINT; MINT-1039894; -.
DR   STRING; Q9Y048; -.
DR   PRIDE; Q9Y048; -.
DR   EnsemblMetazoa; F47G6.1; F47G6.1; F47G6.1.
DR   GeneID; 171715; -.
DR   KEGG; cel:F47G6.1; -.
DR   NMPDR; fig|6239.3.peg.240; -.
DR   UCSC; F47G6.1; c. elegans.
DR   CTD; 171715; -.
DR   WormBase; F47G6.1; CE26812; WBGene00001115; dyb-1.
DR   eggNOG; meNOG04762; -.
DR   GeneTree; EMGT00050000000918; -.
DR   InParanoid; Q9Y048; -.
DR   OMA; DSIRFAT; -.
DR   PhylomeDB; Q9Y048; -.
DR   NextBio; 872407; -.
DR   ArrayExpress; Q9Y048; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016010; C:dystrophin-associated glycoprotein complex; IDA:UniProtKB.
DR   GO; GO:0005277; F:acetylcholine transmembrane transporter activity; IMP:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007529; P:establishment of synaptic specificity at neuromuscular junction; TAS:UniProtKB.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0007626; P:locomotory behavior; IMP:WormBase.
DR   GO; GO:0046716; P:muscle cell homeostasis; IMP:UniProtKB.
DR   GO; GO:0040017; P:positive regulation of locomotion; IMP:UniProtKB.
DR   GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IMP:WormBase.
DR   GO; GO:0045214; P:sarcomere organization; IGI:WormBase.
DR   GO; GO:0007271; P:synaptic transmission, cholinergic; IMP:UniProtKB.
DR   InterPro; IPR017432; Distrobrevin.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR015153; EF-hand_dom_typ1.
DR   InterPro; IPR015154; EF-hand_dom_typ2.
DR   InterPro; IPR000433; Znf_ZZ.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF09068; efhand_1; 1.
DR   Pfam; PF09069; efhand_2; 1.
DR   Pfam; PF00569; ZZ; 1.
DR   PIRSF; PIRSF038204; Distrobrevin; 1.
DR   SMART; SM00291; ZnF_ZZ; 1.
DR   PROSITE; PS01357; ZF_ZZ_1; 1.
DR   PROSITE; PS50135; ZF_ZZ_2; 1.
DR   HOGENOMDNA; CAEELI.PE257; -.
KW   F47G6.1R.800200367fold_1320000031; F47G6.1.18a4200.62fold_1320000031;
KW   AF098989; AJ131742;
KW   Coiled coil; Complete proteome; Cytoplasm; Metal-binding;
KW   Reference proteome; Zinc; Zinc-finger.
SQ   SEQUENCE   590 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLWSNGGGGP REPSSAPSPD HHRAMHSVPP IVASEMQQLI DEMRLQDFDS IRFATYRAAC
     KLRFIQQKTK VHLVDIWNMI EAFRENGLNA LPLHTVIKTS RAELLLTTVF HNLNKRLVAS
     QHVDTDVSIS LLLAFLLGAY DKQNTGRLTV FSIKVALATL CAGKLVDKLR YIFSQIADSN
     GLMDHIKFTD FLQQILSLTT AVFEAPTFGF SENAVNQCFH KDEKVSLNVF LDTFLSDPCP
     PCIMWLPLLH RMASVSNVYH PVVCDACQVR SFTGFRYKCQ RCANYQLCQS CFWRGRTSQN
     HSNEHEMKEY SSYKSPTKQL VHSIHKSLQC IPATSTVGDA NIDIFNAKIG GPVSSKPARP
     LNLNNIVPAT PTTIRRQHAA TSSADWPTSP VLLPGQASHG GVIDDEHKLI ARYAAKLSGR
     ADYPLSNGRS MNSSMVGDER TLIAQLEEEN SMMVREMARL ESQTTSDDGL AGLRDRKMEL
     EEKMFEMQQR RRELMMQLEH LMAQLNTGPQ PSGGVSSASL SQLPFTASDQ QLTGVNSTVA
     NAFRAGSLPA TSLQGDLLHA ADQITTNMSD LVRQLDLAQS DENGVTINGF
//

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