(data stored in ACNUC16935 zone)

HOGENOM: CAEELI_PE3015

ID   CAEELI_PE3015                        STANDARD;      PRT;   77 AA.
AC   CAEELI_PE3015; Q93725;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=NEDD8;AltName: Full=Neddylin;AltName: Full=Protein
DE   NED-8;AltName: Full=Ubiquitin-like protein Nedd8;Flags: Precursor;
DE   (CAEELI.PE3015).
GN   Name=ned-8; ORFNames=F45H11.2;
OS   CAENORHABDITIS ELEGANS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda;
OC   Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAEELI.PE3015.
CC       Caenorhabditis elegans chromosome I WS210  sequence 1..15072421
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:NEDD8_CAEEL
CC   -!- FUNCTION: Ubiquitin-like protein which plays an important role in
CC       cell cycle control and embryogenesis. Covalent attachment to its
CC       substrates requires prior activation by the E1 complex uba-3-ula-1
CC       and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to
CC       cullins activates their associated E3 ubiquitin ligase activity,
CC       and thus promotes polyubiquitination and proteasomal degradation
CC       of cyclins and other regulatory proteins.
CC   -!- SUBUNIT: Interacts with dcn-1. Covalently attached to cullins.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly nuclear
CC       during interphase, also cytoplasmic during interphase and mitosis.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development.
CC   -!- PTM: Cleavage of precursor form is necessary for function (By
CC       similarity).
CC   -!- DISRUPTION PHENOTYPE: Worms either arrest during embryonic
CC       development, or show vulval eversion at the L4 stage and burst at
CC       the vulva during the L4-to-adult molt. Those who survive to the
CC       adult stage display severe defects in terminal differentiation of
CC       seam cells, vulva and male tail.
CC   -!- SIMILARITY: Belongs to the ubiquitin family.
CC   -!- GENE_FAMILY: HOG000233942 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Caenorhabditis_elegans;F45H11.2;F45H11.2;F45H11.2.
DR   EMBL; Z78420; - ;
DR   UniProtKB/Swiss-Prot; Q93725; -.
DR   EMBL; Z78420; CAB01708.1; -; Genomic_DNA.
DR   PIR; T22249; T22249.
DR   RefSeq; NP_492717.1; NM_060316.2.
DR   UniGene; Cel.18712; -.
DR   ProteinModelPortal; Q93725; -.
DR   SMR; Q93725; 1-76.
DR   IntAct; Q93725; 1.
DR   STRING; Q93725; -.
DR   PRIDE; Q93725; -.
DR   EnsemblMetazoa; F45H11.2; F45H11.2; F45H11.2.
DR   GeneID; 172910; -.
DR   KEGG; cel:F45H11.2; -.
DR   NMPDR; fig|6239.3.peg.2768; -.
DR   UCSC; F45H11.2; c. elegans.
DR   CTD; 172910; -.
DR   WormBase; F45H11.2; CE10552; WBGene00003587; ned-8.
DR   eggNOG; meNOG20955; -.
DR   GeneTree; EMGT00050000005052; -.
DR   InParanoid; Q93725; -.
DR   OMA; DYKVQGG; -.
DR   PhylomeDB; Q93725; -.
DR   NextBio; 877495; -.
DR   ArrayExpress; Q93725; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.
DR   GO; GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.
DR   GO; GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
DR   GO; GO:0040025; P:vulval development; IMP:WormBase.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019954; Ubiquitin_CS.
DR   InterPro; IPR019956; Ubiquitin_subgr.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   Pfam; PF00240; ubiquitin; 1.
DR   PRINTS; PR00348; UBIQUITIN.
DR   SMART; SM00213; UBQ; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
DR   HOGENOMDNA; CAEELI.PE3015; -.
KW   F45H11.21180200367fold_1320000031; F45H11.2b121210.62fold_1320000031;
KW   Z78420;
KW   Complete proteome; Cytoplasm; Developmental protein; Isopeptide bond;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
SQ   SEQUENCE   77 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLIKVKTLTG KEIELDIEPN DRVERIKEKV EEKEGIPPPQ QRLIFAGKQM NDDKTAADYK
     VLGGSVLHLV LALRGGF
//

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