(data stored in ACNUC8465 zone)

HOGENOM: CAEELI_PE591

ID   CAEELI_PE591                         STANDARD;      PRT;   387 AA.
AC   CAEELI_PE591; Q10664;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase
DE   mek-2; Short=MAP kinase kinase mek-2; EC=2.7.12 2; (CAEELI.PE591).
GN   Name=mek-2; ORFNames=Y54E10BL.6;
OS   CAENORHABDITIS ELEGANS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Pseudocoelomata; Nematoda;
OC   Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS CAEELI.PE591.
CC       Caenorhabditis elegans chromosome I WS210  sequence 1..15072421
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MEK2_CAEEL
CC   -!- FUNCTION: Functions in the let-60 Ras signaling pathway; acts
CC       downstream of lin-45 raf kinase, but before the sur-1/mpK-1 gene
CC       product in controlling vulval cell differentiation.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated by tyrosine and threonine
CC       phosphorylation catalyzed by MAP kinase kinase kinases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Caenorhabditis_elegans;Y54E10BL.6;Y54E10BL.6;Y54E10BL.6.
DR   EMBL; AC024811; - ;
DR   EMBL; U21107; - ;
DR   UniProtKB/Swiss-Prot; Q10664; -.
DR   EMBL; U21107; AAA85118.1; -; mRNA.
DR   EMBL; AC024811; AAF60779.1; -; Genomic_DNA.
DR   PIR; A56466; A56466.
DR   RefSeq; NP_491087.1; NM_058686.3.
DR   UniGene; Cel.19739; -.
DR   ProteinModelPortal; Q10664; -.
DR   SMR; Q10664; 48-382.
DR   IntAct; Q10664; 3.
DR   MINT; MINT-114232; -.
DR   STRING; Q10664; -.
DR   PRIDE; Q10664; -.
DR   EnsemblMetazoa; Y54E10BL.6; Y54E10BL.6; Y54E10BL.6.
DR   GeneID; 171872; -.
DR   KEGG; cel:Y54E10BL.6; -.
DR   NMPDR; fig|6239.3.peg.549; -.
DR   UCSC; Y54E10BL.6; c. elegans.
DR   CTD; 171872; -.
DR   WormBase; Y54E10BL.6; CE25437; WBGene00003186; mek-2.
DR   eggNOG; meNOG05601; -.
DR   GeneTree; EMGT00050000000989; -.
DR   InParanoid; Q10664; -.
DR   OMA; DIAGWVC; -.
DR   PhylomeDB; Q10664; -.
DR   BRENDA; 2.7.12.2; 1045.
DR   NextBio; 873047; -.
DR   ArrayExpress; Q10664; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR   GO; GO:0001703; P:gastrulation with mouth forming first; IMP:WormBase.
DR   GO; GO:0040007; P:growth; IMP:WormBase.
DR   GO; GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.
DR   GO; GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.
DR   GO; GO:0007265; P:Ras protein signal transduction; IGI:WormBase.
DR   GO; GO:0040025; P:vulval development; IGI:WormBase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; CAEELI.PE591; -.
KW   Y54E10BL.680200367fold_1320000031; Y54E10BL.622910.62fold_1320000031;
KW   AC024811; U21107;
KW   ATP-binding; Complete proteome; Developmental protein; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   387 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSGKRRNPL GLSLPPTVNE QSESGEATAE EATATVPLEE QLKKLGLTEP QTQRLSEFLQ
     VKEGIKELSE DMLQTEGELG HGNGGVVNKC VHRKTGVIMA RKLVHLEIKP SVRQQIVKEL
     AVLHKCNSPF IVGFYGAFVD NNDISICMEY MDGLSLDIVL KKVGRLPEKF VGRISVAVVR
     GLTYLKDEIK ILHRDVKPSN MLVNSNGEIK LCDFGVSGML IDSMANSFVG TRSYMAPERL
     TGSHYTISSD IWSFGLSLVE LLIGRYPVPA PSQAEYATMF NVAENEIELA DSLEEPNYHP
     PSNPASMAIF EMLDYIVNGP PPTLPKRFFT DEVIGFVSKC LRKLPSERAT LKSLTADVFF
     TQYADHDDQG EFAVFVKGTI NLPKLNP
//

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